The antimicrobial activity of Croton membranaceus, a species used in formulations for measles in Ghana

The antimicrobial activity of the methanolic root extract and compounds isolated from Croton membranaceus against the bacteria; Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and fungi; Aspergillus niger and Candida albicans, using the agar diffusion and broth dilution techniques was studied in order to establish its possible usefulness in the treatment of measles. The methanolic extract showed a significant (p 200 g/ml). The activities of gomojoside H were found to be similar to the effects of gentamicin on these organisms. The results therefore indicated that this compound is a potent antibacterial and its presence appears to explain in part the antimicrobial activity exhibited by the C. membranaceus root extract and supports its usefulness in treating secondary bacterial infection in measles.

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