Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

[1]  Yigang Wang,et al.  The Role of Mitochondrial Dynamics and Mitophagy in Carcinogenesis, Metastasis and Therapy , 2020, Frontiers in Cell and Developmental Biology.

[2]  G. Kaltsas,et al.  Increased autophagy/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms , 2020, Endocrine.

[3]  A. Datti,et al.  ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway , 2020, Nature Communications.

[4]  Qi Wang,et al.  Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma. , 2019, American journal of translational research.

[5]  C. Baines,et al.  The Novel Cyclophilin-D Interacting Protein FASTKD1 Protects Cells Against Oxidative Stress-Induced Death. , 2019, American journal of physiology. Cell physiology.

[6]  Yitao Wang,et al.  Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells , 2017, Cell Death and Disease.

[7]  Qiuying Pang,et al.  Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells , 2017, International journal of molecular medicine.

[8]  S. Tait,et al.  Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells. , 2017, Cell reports.

[9]  D. Jang,et al.  Induction of Cell Death by Betulinic Acid through Induction of Apoptosis and Inhibition of Autophagic Flux in Microglia BV-2 Cells , 2017, Biomolecules & therapeutics.

[10]  Tao-Sheng Li,et al.  Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells. , 2017, Cancer letters.

[11]  L. Schöckel,et al.  Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells , 2017, Cell Death and Disease.

[12]  Lei Wang,et al.  Betulinic Acid and its Derivatives as Potential Antitumor Agents , 2015, Medicinal research reviews.

[13]  P. Li,et al.  A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission , 2015, Autophagy.

[14]  D. Kass,et al.  Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain , 2014, The EMBO journal.

[15]  G. Washko,et al.  Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. , 2014, The Journal of clinical investigation.

[16]  B. Westermann,et al.  ER-mitochondria contacts as sites of mitophagosome formation , 2014, Autophagy.

[17]  J. Medema,et al.  Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response , 2014, Cell Death and Disease.

[18]  Jiahuai Han,et al.  Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. , 2014, Nature chemical biology.

[19]  Thomas R Gawriluk,et al.  Autophagy , 2013 .

[20]  Jing He,et al.  Betulinic acid inhibits autophagic flux and induces apoptosis in human multiple myeloma cells in vitro , 2012, Acta Pharmacologica Sinica.

[21]  T. Schwarz,et al.  The pathways of mitophagy for quality control and clearance of mitochondria , 2012, Cell Death and Differentiation.

[22]  S. Fulda,et al.  Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process , 2012, Cell Death and Differentiation.

[23]  R. Youle,et al.  PINK1- and Parkin-mediated mitophagy at a glance , 2012, Journal of Cell Science.

[24]  W. Ye,et al.  Synthesis and antiproliferative evaluation of 23-hydroxybetulinic acid derivatives. , 2011, European journal of medicinal chemistry.

[25]  N. Mizushima,et al.  Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane*♦ , 2011, The Journal of Biological Chemistry.

[26]  Wolfdieter Springer,et al.  Regulation of PINK1-Parkin-mediated mitophagy , 2011, Autophagy.

[27]  Sonja Hess,et al.  Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy , 2011, Human molecular genetics.

[28]  L. Scorrano,et al.  During autophagy mitochondria elongate, are spared from degradation and sustain cell viability , 2011, Nature Cell Biology.

[29]  R. Paschke,et al.  Synthesis and Anticancer Activity of Novel Betulinic acid and Betulin Derivatives , 2010, Archiv der Pharmazie.

[30]  B. Aggarwal,et al.  Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP‐1 in human multiple myeloma cells , 2010, International journal of cancer.

[31]  M. Cascante,et al.  Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid. , 2010, Bioorganic & medicinal chemistry.

[32]  S. Safe,et al.  Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells , 2010, Molecular Cancer Research.

[33]  N. Ktistakis,et al.  Regulation of autophagy by phosphatidylinositol 3‐phosphate , 2010, FEBS letters.

[34]  Fabienne C. Fiesel,et al.  PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 , 2010, Nature Cell Biology.

[35]  R. Youle,et al.  Parkin is recruited selectively to impaired mitochondria and promotes their autophagy , 2008, The Journal of cell biology.

[36]  S. Shukla,et al.  Betulinic acid suppresses constitutive and TNFα‐induced NF‐κB activation and induces apoptosis in human prostate carcinoma PC‐3 cells , 2008, Molecular carcinogenesis.

[37]  P. Sharma,et al.  Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives. , 2008, Bioorganic & medicinal chemistry letters.

[38]  P. Codogno,et al.  Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells , 2008, Cell Death and Differentiation.

[39]  C. Chu,et al.  Beclin 1-Independent Pathway of Damage-Induced Mitophagy and Autophagic Stress: Implications for Neurodegeneration and Cell Death , 2007, Autophagy.

[40]  Eun Hee Kim,et al.  Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. , 2007, Cancer research.

[41]  M. Gottesman,et al.  Targeting multidrug resistance in cancer , 2006, Nature Reviews Drug Discovery.

[42]  J. Whisstock,et al.  The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. , 2005, Molecular biology of the cell.

[43]  J. Robert,et al.  Multidrug resistance reversal agents. , 2003, Journal of medicinal chemistry.

[44]  M. Layton,et al.  Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Erik E. Griffin,et al.  Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development , 2003, The Journal of cell biology.

[46]  M. Zvelebil,et al.  Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors , 2000, Molecular and Cellular Biology.

[47]  Aris Persidis,et al.  Cancer multidrug resistance , 1999, Nature Biotechnology.

[48]  Robert Altenloh From a Novel , 1953 .