Forensic intelligence for medicine anti-counterfeiting.

Medicine counterfeiting is a crime that has increased in recent years and now involves the whole world. Health and economic repercussions have led pharmaceutical industries and agencies to develop many measures to protect genuine medicines and differentiate them from counterfeits. Detecting counterfeit is chemically relatively simple for the specialists, but much more information can be gained from the analyses in a forensic intelligence perspective. Analytical data can feed criminal investigation and law enforcement by detecting and understanding the criminal phenomenon. Profiling seizures using chemical and packaging data constitutes a strong way to detect organised production and industrialised forms of criminality, and is the focus of this paper. Thirty-three seizures of a commonly counterfeited type of capsule have been studied. The results of the packaging and chemical analyses were gathered within an organised database. Strong linkage was found between the seizures at the different production steps, indicating the presence of a main counterfeit network dominating the market. The interpretation of the links with circumstantial data provided information about the production and the distribution of counterfeits coming from this network. This forensic intelligence perspective has the potential to be generalised to other types of products. This may be the only reliable approach to help the understanding of the organised crime phenomenon behind counterfeiting and to enable efficient strategic and operational decision making in an attempt to dismantle counterfeit network.

[1]  Pierre Margot,et al.  Profiling of counterfeit medicines by vibrational spectroscopy. , 2011, Forensic science international.

[2]  S. Stegemann Hard gelatin capsules today - and tomorrow , 2002 .

[3]  A. Wertheimer,et al.  Safeguarding against substandard/counterfeit drugs: mitigating a macroeconomic pandemic. , 2009, Research in social & administrative pharmacy : RSAP.

[4]  A. Attaran,et al.  Why and How to Make an International Crime of Medicine Counterfeiting , 2011 .

[5]  Paul N. Newton,et al.  Prevalence and Detection of Counterfeit Pharmaceuticals: A Mini Review , 2008 .

[6]  Anand Date,et al.  Aplicación de la profilaxis con cotrimoxazol y la terapia preventiva con isoniazida en los afectados por el VIH , 2010 .

[7]  Lynne S. Taylor,et al.  Analysis of the packaging enclosing a counterfeit pharmaceutical tablet using Raman microscopy and two-dimensional correlation spectroscopy , 2012 .

[8]  P Margot,et al.  Case based reasoning in criminal intelligence using forensic case data. , 2003, Science & justice : journal of the Forensic Science Society.

[9]  Pierre Margot,et al.  Identification of pharmaceutical tablets by Raman spectroscopy and chemometrics. , 2010, Talanta.

[10]  Jean-Claude Wolff,et al.  Investigation into classification/sourcing of suspect counterfeit Heptodintrade mark tablets by near infrared chemical imaging. , 2009, Analytica chimica acta.

[11]  L. Li Technology designed to combat fakes in the global supply chain , 2013 .

[12]  C. L. Narayana,et al.  LC method for the determination of assay and purity of sibutramine hydrochloride and its enantiomers by chiral chromatography. , 2000, Journal of pharmaceutical and biomedical analysis.

[13]  Roger Bate,et al.  A counterfeit drug treaty: great idea, wrong implementation , 2010, The Lancet.

[14]  Roger Bate,et al.  Pilot Study Comparing Technologies to Test for Substandard Drugs in Field Settings , 2009 .

[15]  P. Esseiva Le profilage de l'héroïne et de la cocaïne : mise en place d'une systèmatique permettant une utilisation opérationnelle des liens chimiques , 2004 .

[16]  Claude Roux,et al.  Forensic intelligence framework--Part I: Induction of a transversal model by comparing illicit drugs and false identity documents monitoring. , 2014, Forensic science international.

[17]  B. Bloodworth,et al.  Detection of sibutramine, its two metabolites and one analogue in a herbal product for weight loss by liquid chromatography triple quadrupole mass spectrometry and time-of-flight mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.

[18]  C. Zingg,et al.  The analysis of ecstasy tablets in a forensic drug intelligence perspective , 2005 .

[19]  Becky Beal,et al.  `Keeping It Real' , 2003 .

[20]  Edmond Locard,et al.  L'enquête criminelle et les méthodes scientifiques , 1920 .

[21]  Y. Roggo,et al.  Detection and chemical profiling of medicine counterfeits by Raman spectroscopy and chemometrics. , 2011, Analytica chimica acta.

[22]  Pierre Margot,et al.  Understanding and fighting the medicine counterfeit market. , 2014, Journal of pharmaceutical and biomedical analysis.

[23]  C. Ricci,et al.  Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs , 2007, Analytical and bioanalytical chemistry.

[24]  P. Newton,et al.  The Primacy of Public Health Considerations in Defining Poor Quality Medicines , 2011, PLoS Medicine.

[25]  Christina Y Hampton,et al.  A Collaborative Epidemiological Investigation into the Criminal Fake Artesunate Trade in South East Asia , 2008, PLoS medicine.

[26]  P Hayoz,et al.  Establishment of an operational system for drug profiling: a Swiss experience. , 2005, Bulletin on narcotics.

[27]  T. De Beer,et al.  Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. , 2010, Journal of pharmaceutical and biomedical analysis.

[28]  B. Venhuis,et al.  The identification of rimonabant polymorphs, sibutramine and analogues of both in counterfeit Acomplia bought on the internet. , 2011, Journal of pharmaceutical and biomedical analysis.

[29]  Marv Shepherd Beef up international cooperation on counterfeits , 2010, Nature Medicine.

[30]  Shiji Zhou,et al.  Establishment of a Fast Chemical Identification System for screening of counterfeit drugs of macrolide antibiotics. , 2006, Journal of pharmaceutical and biomedical analysis.

[31]  A. Mozayani,et al.  Analysis of Alprazolam by DART‐TOF Mass Spectrometry in Counterfeit and Routine Drug Identification Cases , 2011, Journal of forensic sciences.

[32]  Eric Przyswa,et al.  Counterfeit medicines and criminal organisations , 2013 .

[33]  Sreenivasulu N.S Intellectual Property Right , 2011 .

[34]  A. Seiter Health and Economic Consequences of Counterfeit Drugs , 2009, Clinical pharmacology and therapeutics.

[35]  It Istituto Superiore di Sanit,et al.  Identification and analysis of counterfeit and substandard pharmaceuticals: thermal analysis in the study of counterfeit medicines , 2013 .