The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.
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[1] G. Hitchings,et al. Inhibition of folate biosynthesis and function as a basis for chemotherapy. , 1965, Advances in enzymology and related areas of molecular biology.
[2] G. Brown,et al. The biosynthesis of pteridines. , 1971, Advances in enzymology and related areas of molecular biology.
[3] R. Gleckman,et al. Drug therapy reviews: trimethoprim-sulfamethoxazole. , 1979, American journal of hospital pharmacy.
[4] R. Read. Improved Fourier Coefficients for Maps Using Phases from Partial Structures with Errors , 1986 .
[5] Dihydrofolate reductase: specificity and conformational change. , 1987, Biochemical Society transactions.
[6] T. Teng,et al. Mounting of crystals for macromolecular crystallography in a free-standing thin film , 1990 .
[7] P. Kraulis. A program to produce both detailed and schematic plots of protein structures , 1991 .
[8] A. Brunger. Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. , 1992 .
[9] D. Stammers,et al. The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase. , 1992, Gene.
[10] G. Barton,et al. Multiple protein sequence alignment from tertiary structure comparison: Assignment of global and residue confidence levels , 1992, Proteins.
[11] J. Thornton,et al. PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .
[12] S. Lacks,et al. A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities , 1993, Journal of bacteriology.
[13] G J Barton,et al. ALSCRIPT: a tool to format multiple sequence alignments. , 1993, Protein engineering.
[14] M. Lawrence,et al. Shape complementarity at protein/protein interfaces. , 1993, Journal of molecular biology.
[15] J. E. Hyde,et al. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. , 1994, European journal of biochemistry.
[16] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[17] J. Thornton,et al. Satisfying hydrogen bonding potential in proteins. , 1994, Journal of molecular biology.
[18] P. Weber,et al. Role of L-type calcium channels on stimulated calcium influx and on proliferative activity of human coronary smooth muscle cells. , 1994, Journal of cardiovascular pharmacology.
[19] A. Brünger,et al. Torsion angle dynamics: Reduced variable conformational sampling enhances crystallographic structure refinement , 1994, Proteins.
[20] C. Delves,et al. Two domains with amino-acid sequence similarity are required for dihydroneopterin aldolase function in the multifunctional folic acid synthesis Fas protein of Pneumocystis carinii. , 1995, Gene.
[21] J. Garin,et al. Folate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6‐hydroxymethyl‐7,8‐dihydropterin pyrophosphokinase/7,8‐dihydropteroate synthase localized in mitochondria , 1997, The EMBO journal.
[22] M. Page,et al. Structure and function of the dihydropteroate synthase from Staphylococcus aureus. , 1997, Journal of molecular biology.
[23] J. E. Hyde,et al. Isolation and molecular characterization of the bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase gene from Toxoplasma gondii. , 1997, Molecular and biochemical parasitology.
[24] Z. Otwinowski,et al. [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.
[25] J. Champness,et al. Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase , 1997, Nature Structural Biology.
[26] G. Murshudov,et al. Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.
[27] J. Hegemann,et al. Sequence Analysis of the 33 kb Long Region Between ORC5 and SUI1 from the Left Arm of Chromosome XIV from Saccharomyces cerevisiae , 1997, Yeast.
[28] E A Merritt,et al. Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.
[29] A. Vagin,et al. MOLREP: an Automated Program for Molecular Replacement , 1997 .
[30] Single amino acid substitutions disrupt tetramer formation in the dihydroneopterin aldolase enzyme of Pneumocystis carinii. , 1998, Biochemistry.
[31] M. Page,et al. Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from staphylococcus aureus , 1998, Nature Structural Biology.
[32] Honggao Yan,et al. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. , 1999, Structure.
[33] C. Gray,et al. The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae. , 1999, Journal of molecular biology.
[34] J. Champness,et al. 2.0 Å X‐ray structure of the ternary complex of 7,8‐dihydro‐6‐hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue , 1999, FEBS letters.
[35] E. W. Miles,et al. The Molecular Basis of Substrate Channeling* , 1999, The Journal of Biological Chemistry.
[36] Honggao Yan,et al. Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution. , 2000, Structure.
[37] T. N. Bhat,et al. The Protein Data Bank , 2000, Nucleic Acids Res..
[38] J. Derrick,et al. Equilibrium and Kinetic Studies of Substrate Binding to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase fromEscherichia coli* , 2000, The Journal of Biological Chemistry.
[39] R. Perham,et al. Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. , 2000, Annual review of biochemistry.
[40] W. Hol,et al. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. , 2000, Journal of molecular biology.
[41] M. Lawrence,et al. CONSCRIPT: a program for generating electron density isosurfaces for presentation in protein crystallography , 2000 .
[42] S. Salzberg,et al. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. , 2000, Nucleic acids research.
[43] Honggao Yan,et al. Unusual Conformational Changes in 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase as Revealed by X-ray Crystallography and NMR* , 2001, The Journal of Biological Chemistry.
[44] T L Blundell,et al. FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties. , 2001, Journal of molecular biology.
[45] G N Murshudov,et al. Use of TLS parameters to model anisotropic displacements in macromolecular refinement. , 2001, Acta crystallographica. Section D, Biological crystallography.
[46] J. Błaszczyk,et al. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. , 2001, Journal of medicinal chemistry.
[47] F. Raushel,et al. Channeling of substrates and intermediates in enzyme-catalyzed reactions. , 2001, Annual review of biochemistry.
[48] George N. Bennett,et al. Genome Sequence and Comparative Analysis of the Solvent-Producing Bacterium Clostridium acetobutylicum , 2001, Journal of bacteriology.
[49] M. Hattori,et al. Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[50] Peer Bork,et al. The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[51] B. Barrell,et al. The genome sequence of Schizosaccharomyces pombe , 2002, Nature.
[52] Chemical transformation is not rate-limiting in the reaction catalyzed by Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. , 2002, Biochemistry.
[53] Nikos Kyrpides,et al. Genome Sequence and Analysis of the Oral Bacterium Fusobacterium nucleatum Strain ATCC 25586 , 2002, Journal of bacteriology.
[55] Michael L Wilson,et al. Conventional and molecular epidemiology of trimethoprim-sulfamethoxazole resistance among urinary Escherichia coli isolates. , 2003, The American journal of medicine.
[56] A. Sali,et al. Modeller: generation and refinement of homology-based protein structure models. , 2003, Methods in enzymology.
[57] E. Mauceli,et al. The genome sequence of the filamentous fungus Neurospora crassa , 2003, Nature.
[58] S. Meshnick,et al. Promoter strength of folic acid synthesis genes affects sulfa drug resistance in Saccharomyces cerevisiae. , 2003, Microbial drug resistance.
[59] N. Nagradova. Interdomain Communications in Bifunctional Enzymes: How Are Different Activities Coordinated? , 2003, IUBMB life.
[60] Honggao Yan,et al. Dynamic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: crystallographic studies. , 2003, Biochemistry.
[61] M. Peng,et al. Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection. , 2004, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
[62] J. Janin,et al. A dissection of specific and non-specific protein-protein interfaces. , 2004, Journal of molecular biology.
[63] R. Huber,et al. Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class. , 2004, Journal of molecular biology.
[64] Yue Li,et al. Essential roles of a dynamic loop in the catalysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. , 2004, Biochemistry.
[65] S. White,et al. Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design. , 2004, Structure.
[66] S. Meshnick,et al. Cloning of the Pneumocystis jirovecii trifunctional FAS gene and complementation of its DHPS activity in Escherichia coli. , 2004, Fungal genetics and biology : FG & B.
[67] Yue Li,et al. Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. , 2004, Structure.
[68] Jean M. Severin,et al. Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization. , 2004, Journal of medicinal chemistry.
[69] R. Fernley,et al. Purification, properties, and crystallization of Saccharomyces cerevisiae dihydropterin pyrophosphokinase-dihydropteroate synthase. , 2005, Protein expression and purification.