Elucidating the molecular mechanism for the intracellular trafficking and fate of block copolymer micelles and their components.

[1]  Wenbin Lin,et al.  Polymeric Micelle-Mediated Delivery of DNA-Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment. , 2015, Small.

[2]  Chao Zhang,et al.  Endosomal pH-Responsive Polymer-Based Dual-Ligand-Modified Micellar Nanoparticles for Tumor Targeted Delivery and Facilitated Intracellular Release of Paclitaxel , 2015, Pharmaceutical Research.

[3]  Y. Bae,et al.  A Multilayered Cell Culture Model for Transport Study in Solid Tumors: Evaluation of Tissue Penetration of Polyethyleneimine Based Cationic Micelles. , 2014, Nano today.

[4]  Robert Langer,et al.  Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling , 2013, Nature Biotechnology.

[5]  Y. Barenholz Doxil®--the first FDA-approved nano-drug: lessons learned. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[6]  Akiko Ishii-Watabe,et al.  Evaluation of intracellular trafficking and clearance from HeLa cells of doxorubicin-bound block copolymers. , 2012, International journal of pharmaceutics.

[7]  R. Rachel,et al.  Comparative Investigations on In Vitro Serum Stability of Polymeric Micelle Formulations , 2012, Pharmaceutical Research.

[8]  M. Morilla,et al.  Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages , 2011, International journal of nanomedicine.

[9]  R. Duncan,et al.  Nanomedicine(s) under the microscope. , 2011, Molecular pharmaceutics.

[10]  Hideyoshi Harashima,et al.  A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. , 2011, Advanced drug delivery reviews.

[11]  Yu Matsumoto,et al.  Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting , 2011, Science Translational Medicine.

[12]  E. Martínez-Alonso,et al.  Regulation of ER–Golgi Intermediate Compartment Tubulation and Mobility by COPI Coats, Motor Proteins and Microtubules , 2010, Traffic.

[13]  T. Yamaji,et al.  CERT-mediated trafficking of ceramide. , 2009, Biochimica et biophysica acta.

[14]  P. Verkade,et al.  Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development , 2008, Journal of Cell Science.

[15]  Alexander V Kabanov,et al.  Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Gaurav Sahay,et al.  Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport. , 2008, Bioconjugate chemistry.

[17]  P. Low,et al.  Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo forster resonance energy transfer imaging. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[18]  Elina Ikonen,et al.  Cellular cholesterol trafficking and compartmentalization , 2008, Nature Reviews Molecular Cell Biology.

[19]  E. Ikonen,et al.  Endocytic trafficking of sphingomyelin depends on its acyl chain length. , 2007, Molecular biology of the cell.

[20]  K. Uematsu,et al.  Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth. , 2007, Anticancer research.

[21]  T. Arakawa,et al.  SNAP‐23 is not essential for constitutive exocytosis in HeLa cells , 2007, FEBS letters.

[22]  A. Nakano,et al.  Mechanisms of COPII vesicle formation and protein sorting , 2007, FEBS letters.

[23]  Kazunori Kataoka,et al.  Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. , 2006, Pharmacology & therapeutics.

[24]  T. Onda,et al.  Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular endothelial growth factor-secreting bulky tumors. , 2006, Cancer research.

[25]  N. Ohgami,et al.  Roles of Endogenously Synthesized Sterols in the Endocytic Pathway* , 2006, Journal of Biological Chemistry.

[26]  N. Nishiyama,et al.  Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats , 2005, British Journal of Cancer.

[27]  M. Conese,et al.  Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[28]  E. Ikonen,et al.  Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis. , 2005, The Biochemical journal.

[29]  E. Ikonen,et al.  MLN64 is involved in actin-mediated dynamics of late endocytic organelles. , 2005, Molecular biology of the cell.

[30]  K. Kataoka,et al.  NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel , 2005, British Journal of Cancer.

[31]  M. Ferrari Cancer nanotechnology: opportunities and challenges , 2005, Nature Reviews Cancer.

[32]  J. Bonifacino,et al.  The Mechanisms of Vesicle Budding and Fusion , 2004, Cell.

[33]  Satoshi Yasuda,et al.  Molecular machinery for non-vesicular trafficking of ceramide , 2003, Nature.

[34]  S. Cockcroft,et al.  Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin. , 2002, The Biochemical journal.

[35]  Vladimir P Torchilin,et al.  PEG-based micelles as carriers of contrast agents for different imaging modalities. , 2002, Advanced drug delivery reviews.

[36]  E. Ikonen,et al.  ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. , 2002, Journal of lipid research.

[37]  F. Maxfield,et al.  Vesicular and Non-vesicular Sterol Transport in Living Cells , 2002, The Journal of Biological Chemistry.

[38]  Y. Ioannou Multidrug permeases and subcellular cholesterol transport , 2001, Nature Reviews Molecular Cell Biology.

[39]  J. Hsuan,et al.  The PITP family of phosphatidylinositol transfer proteins , 2001, Genome Biology.

[40]  Richard G. W. Anderson,et al.  Potocytosis , 2001, Histochemistry and Cell Biology.

[41]  T. Okano,et al.  Development of the polymer micelle carrier system for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[42]  N. Ridgway,et al.  Novel Members of the Human Oxysterol-binding Protein Family Bind Phospholipids and Regulate Vesicle Transport* , 2001, The Journal of Biological Chemistry.

[43]  S. Kohlwein,et al.  A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. , 2001, European journal of biochemistry.

[44]  J. Hanover,et al.  Cessation of rapid late endosomal tubulovesicular trafficking in Niemann–Pick type C1 disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Y. Tanigawara Role of P-glycoprotein in drug disposition. , 2000, Therapeutic drug monitoring.

[46]  J. Chayvialle,et al.  Expression of SNARE proteins in enteroendocrine cell lines and functional role of tetanus toxin‐sensitive proteins in cholecystokinin release , 1998, FEBS letters.

[47]  K. Wirtz Phospholipid transfer proteins revisited. , 1997, The Biochemical journal.

[48]  Yokoyama Masayuki,et al.  Block copolymer micelles as vehicles for drug delivery , 1993 .

[49]  A. Kabanov,et al.  Pluronic Block Copolymers for Gene Delivery. , 2005, Advances in genetics.