The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection.

[1]  D. Speiser,et al.  T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? , 2014, Nature Reviews Immunology.

[2]  R. Ahmed,et al.  Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection , 2014, The Journal of experimental medicine.

[3]  E. Yang,et al.  Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen , 2013, Nature Immunology.

[4]  Michael Q. Zhang,et al.  The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. , 2013, Immunity.

[5]  B. Faubert,et al.  CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability , 2013, Proceedings of the National Academy of Sciences.

[6]  J. Sullivan,et al.  FoxO1 Controls Effector-to-Memory Transition and Maintenance of Functional CD8 T Cell Memory , 2013, The Journal of Immunology.

[7]  B. Faubert,et al.  Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis , 2013, Cell.

[8]  Stephen M. Hedrick,et al.  Differentiation of CD8 memory T cells depends on Foxo1 , 2013, The Journal of experimental medicine.

[9]  V. Boussiotis,et al.  PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2 , 2013, Molecular and Cellular Biology.

[10]  Adam Williams,et al.  The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. , 2013, Immunity.

[11]  G. Freeman,et al.  Strength of PD-1 signaling differentially affects T-cell effector functions , 2013, Proceedings of the National Academy of Sciences.

[12]  E. Pearce,et al.  Metabolic pathways in immune cell activation and quiescence. , 2013, Immunity.

[13]  Michael Loran Dustin,et al.  PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis , 2013, The Journal of experimental medicine.

[14]  M. Kurrer,et al.  Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice , 2012, The Journal of experimental medicine.

[15]  E John Wherry,et al.  Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. , 2012, Immunity.

[16]  David K. Finlay,et al.  PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells , 2012, The Journal of experimental medicine.

[17]  Burton E. Barnett,et al.  Progenitor and Terminal Subsets of CD8+ T Cells Cooperate to Contain Chronic Viral Infection , 2012, Science.

[18]  Shane J. Neph,et al.  Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification , 2012, Cell.

[19]  A. Goldrath,et al.  FOXO transcription factors throughout T cell biology , 2012, Nature Reviews Immunology.

[20]  J. Sullivan,et al.  FOXO3 Regulates the CD8 T Cell Response to a Chronic Viral Infection , 2012, Journal of Virology.

[21]  Takashi Saito,et al.  Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 , 2012, The Journal of experimental medicine.

[22]  E. Wherry,et al.  Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection , 2012, Journal of Virology.

[23]  Melba Marie Tejera,et al.  Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation , 2012, The Journal of Immunology.

[24]  M. Horton,et al.  Regulation of immune responses by mTOR. , 2012, Annual review of immunology.

[25]  Qingsheng Li,et al.  Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation. , 2012, Immunity.

[26]  S. Peng,et al.  FOXO3 Regulates CD8 T Cell Memory by T Cell-Intrinsic Mechanisms , 2012, PLoS pathogens.

[27]  D. Green,et al.  The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. , 2011, Immunity.

[28]  S. Kaech,et al.  An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. , 2011, Immunity.

[29]  S. Saccani,et al.  Rapamycin‐sensitive signals control TCR/CD28‐driven Ifng, Il4 and Foxp3 transcription and promoter region methylation , 2011, European journal of immunology.

[30]  E John Wherry,et al.  T cell exhaustion , 2011 .

[31]  Pedro Romero,et al.  Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. , 2011, The Journal of clinical investigation.

[32]  E. Wherry,et al.  T-bet represses expression of PD-1 and sustains virus-specific CD8 T cell responses during chronic infection , 2011, Nature Immunology.

[33]  David K. Finlay,et al.  Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism , 2011, Immunity.

[34]  D. Cantrell,et al.  Metabolism, migration and memory in cytotoxic T cells , 2011, Nature Reviews Immunology.

[35]  Daniel R. Beisner,et al.  Foxo transcription factors control regulatory T cell development and function. , 2010, Immunity.

[36]  Greg M. Delgoffe,et al.  The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. , 2010, Immunity.

[37]  Nikhil S. Joshi,et al.  Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival , 2010, Proceedings of the National Academy of Sciences.

[38]  R. DePinho,et al.  Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells , 2010, Nature Immunology.

[39]  Scott N. Mueller,et al.  PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. , 2010, The Journal of clinical investigation.

[40]  J. Rathmell,et al.  The metabolic life and times of a T‐cell , 2010, Immunological reviews.

[41]  Qingsheng Li,et al.  The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. , 2010, Immunity.

[42]  Loise M. Francisco,et al.  PD-L1 regulates the development, maintenance, and function of induced regulatory T cells , 2009, The Journal of experimental medicine.

[43]  J. Bluestone,et al.  Interactions between programmed death-1 and programmed death ligand-1 promote tolerance by blocking the T cell receptor-induced stop signal , 2009, Nature Immunology.

[44]  David K. Finlay,et al.  Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes , 2009, The Journal of experimental medicine.

[45]  E. Wherry,et al.  A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. , 2009, Immunity.

[46]  E. Wherry,et al.  Redefining Chronic Viral Infection , 2009, Cell.

[47]  Russell G. Jones,et al.  Enhancing CD8 T-cell memory by modulating fatty acid metabolism , 2009, Nature.

[48]  R. Ahmed,et al.  mTOR regulates memory CD8 T cell differentiation , 2009, Nature.

[49]  J. Riley PD‐1 signaling in primary T cells , 2009, Immunological reviews.

[50]  R. Flavell,et al.  An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. , 2009, Immunity.

[51]  Daniel R. Beisner,et al.  Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor , 2009, Nature Immunology.

[52]  R. Ahmed,et al.  NFATc1 Regulates PD-1 Expression upon T Cell Activation1 , 2008, The Journal of Immunology.

[53]  A. Brunet,et al.  The FoxO code , 2008, Oncogene.

[54]  M. Birnbaum,et al.  The role of FoxO in the regulation of metabolism , 2008, Oncogene.

[55]  J. Rathmell,et al.  Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 , 2008, The Journal of Immunology.

[56]  G. Freeman,et al.  PD-1 and its ligands in tolerance and immunity. , 2008, Annual review of immunology.

[57]  S. Gygi,et al.  The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.

[58]  E. Wherry,et al.  Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection , 2007, The Journal of experimental medicine.

[59]  David A Hildeman,et al.  Role of Bim in Regulating CD8+ T-Cell Responses during Chronic Viral Infection , 2006, Journal of Virology.

[60]  D. McGavern,et al.  Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. , 2006, The Journal of clinical investigation.

[61]  G. Freeman,et al.  Restoring function in exhausted CD8 T cells during chronic viral infection , 2006, Nature.

[62]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[63]  A. Lanfranco,et al.  CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms , 2004, Molecular and Cellular Biology.

[64]  K. Sheppard,et al.  PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ , 2004 .

[65]  C. June,et al.  SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation1 , 2004, The Journal of Immunology.

[66]  C. Thompson,et al.  The CD28 signaling pathway regulates glucose metabolism. , 2002, Immunity.

[67]  A. Sette,et al.  In Vivo Selection of a Lymphocytic Choriomeningitis Virus Variant That Affects Recognition of the GP33-43 Epitope by H-2Db but Not H-2Kb , 2001, Journal of Virology.

[68]  T. Hunter,et al.  Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[70]  H. Pircher,et al.  Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen , 1989, Nature.

[71]  Michael Q. Zhang,et al.  Novel Foxo 1 – dependent transcriptional programs control T reg cell function , 2013 .

[72]  K. Sheppard,et al.  PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. , 2004, FEBS letters.