The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease.

Significant loss of neurons in the pedunculopontine nucleus pars compacta (PPNc), a putative cholinergic nucleus involved in modulating somatic motor activities, has been demonstrated in progressive supranuclear palsy (PSP) and Parkinson's disease but not in Alzheimer's disease. A morphometric study of this nucleus was performed in two cases of PSP and in a cohort of cases of Parkinson's disease, Alzheimer's disease, senile dementia of Alzheimer type (SDAT), and age-matched controls. In PSP a significant 60% neuronal loss in PPNc was associated with neurofibrillary tangles in 40 to 64% of the remaining neurons. In Parkinson's disease there was a significant decrease in cell numbers and density by 53 and 51%, respectively, with Lewy bodies involving 6 to 39% of all neurons. In Alzheimer's disease and SDAT, large neurons were reduced by 29 and 33.8%, respectively, with tangles in 9 to 38% of the remaining cells. The selective affection of this putative cholinergic nucleus in PSP and Parkinson's disease appears to be related to motor dysfunctions in these disorders.

[1]  K. Jellinger,et al.  Progressive supranuclear palsy: clinico-pathological and biochemical studies. , 1980, Journal of neural transmission. Supplementum.

[2]  A M Graybiel,et al.  Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. D. Boyd,et al.  Cytoarchitecture of the Human Brain Stem , 1955 .

[4]  Usunoff Kg.  Tegmentonigral projection in the cat: electron microscopic observations. , 1984 .

[5]  P. Yates,et al.  Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. , 1986, Human neurobiology.

[6]  U. Slager,et al.  Pathologic correlates of dementia in Parkinson's disease. , 1986, Archives of neurology.

[7]  R. Spencer,et al.  A cholinergic projection to the rat substantia nigra from the pedunculopontine tegmental nucleus , 1987, Brain Research.

[8]  A. Jackson,et al.  Nucleus tegmenti pedunculopontinus: Efferent connections with special reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase , 1983, Neuroscience.

[9]  A. Hirano,et al.  Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons , 1985, Annals of neurology.

[10]  T. Hattori,et al.  Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects , 1984, Neuroscience.

[11]  D L Price,et al.  The pedunculopontine nucleus in Parkinson's disease , 1989, Annals of neurology.

[12]  A M Graybiel,et al.  Neurochemically specified subsystems in the basal ganglia. , 2008, Ciba Foundation symposium.

[13]  P J Whitehouse,et al.  The concept of subcortical and cortical dementia: Another look , 1986, Annals of neurology.

[14]  Niall Quinn,et al.  Young onset Parkinson's disease , 1987, Movement disorders : official journal of the Movement Disorder Society.

[15]  D. Price,et al.  Loss of pedunculopontine neurons in progressive supranuclear palsy , 1987, Annals of neurology.

[16]  K. Jellinger.  Neuropathological substrates of Alzheimer's disease and Parkinson's disease. , 1987, Journal of neural transmission. Supplementum.

[17]  P. Yates,et al.  Loss of nerve cells from locus coeruleus in Alzheimer's disease is topographically arranged , 1986, Neuroscience Letters.

[18]  K. Jellinger.  Quantitative changes in some subcortical nuclei in aging, Alzheimer's disease and Parkinson's disease , 1987, Neurobiology of Aging.

[19]  M. Mesulam,et al.  Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry , 1984, Neuroscience.

[20]  A. Jayaraman.  Organization of thalamic projections in the nucleus accumbens and the caudate nucleus in cats and its relation with hippocampal and other subcortical afferents , 1985, The Journal of comparative neurology.