SYNTHESIS OF AZOLES, AZINES AND AZOLOAZINES: A VERSATILE APPROACH

Abstract A novel procedure for the synthesis of heterocycles 5, 7 have been developed from the acid catalysed condensation-cyclization of benzylidene and benzylmalononitriles with thiosemicarbazide. Base catalysed cyclization of 2 with dicyandiamide led to the formation of pyrimidine 3. Reaction of 5 and 7 with phenacyl bromide separately afforded 6 and 8 while interaction of 7 with ethyl acetoacetate gave a mixture of 9 and 10.

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