PDK1, one of the missing links in insulin signal transduction? 1
暂无分享,去创建一个
[1] M. Andjelkovic,et al. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[2] A. Klippel,et al. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt , 1997, Molecular and cellular biology.
[3] D. Pot,et al. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain , 1997, Molecular and cellular biology.
[4] C. Ware,et al. Dominant Negative Mutants of TRAF3 Reveal an Important Role for the Coiled Coil Domains in Cell Death Signaling by the Lymphotoxin-β Receptor* , 1997, The Journal of Biological Chemistry.
[5] A. Klippel,et al. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways , 1996, Molecular and cellular biology.
[6] William Arbuthnot Sir Lane,et al. Role of IRS-2 in insulin and cytokine signalling , 1995, Nature.
[7] E. Krebs,et al. An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. , 1968, The Journal of biological chemistry.
[8] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[9] P. Cohen,et al. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.
[10] P. Cohen. The regulation of protein function by multisite phosphorylation , 1976 .
[11] R. Roth,et al. Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase. , 1995, The EMBO journal.
[12] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[13] C. Kahn,et al. Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. , 1982, Science.
[14] K. Kameyama,et al. Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and βγ Subunits of G Proteins , 1995 .
[15] O. Hazeki,et al. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. , 1995, Trends in biochemical sciences.
[16] R. Roth,et al. Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation* , 1996, The Journal of Biological Chemistry.
[17] T. Soderling. Regulation of glycogen synthetase. Specificity and stoichiometry of phosphorylation of the skeletal muscle enzyme by cyclic 3':5'-AMP-dependent protein kinase. , 1975, The Journal of biological chemistry.
[18] P. Tsichlis,et al. Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase , 1996, The Journal of Biological Chemistry.
[19] M. Andjelkovic,et al. High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity* , 1997, The Journal of Biological Chemistry.
[20] L. Cantley,et al. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate , 1988, Nature.
[21] P. Cohen,et al. Glycogen synthetase kinase 2 (GSK 2); The identification of a new protein kinase in skeletal muscle , 1974, FEBS letters.
[22] B. Hemmings,et al. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[23] M. White,et al. The IRS-1 signaling system. , 1994, Trends in biochemical sciences.
[24] J. Cheng,et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[25] P. Cohen,et al. Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue , 1997, FEBS letters.
[26] J. Testa,et al. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. , 1991, Science.
[27] A. Cohen. Sugar and diabetes , 1976 .
[28] G. Crabtree,et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.
[29] David R. Kaplan,et al. Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate , 1997, Science.
[30] E. Krebs,et al. Effect of denaturation on the susceptibility of proteins to enzymic phosphorylation. , 1975, The Journal of biological chemistry.
[31] C. Proud,et al. Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. , 1993, The Biochemical journal.
[32] C. Villar-Palasi,et al. UDP-glucose:glycogen alpha-4-glucosyltransferase I kinase activity of purified muscle protein kinase. Cyclic nucleotide specificity. , 1969, Biochimica et Biophysica Acta.
[33] J. Larner,et al. STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. III. INTERCONVERSION OF TWO FORMS OF MUSCLE UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE BY A PHOSPHORYLATION-DEPHOSPHORYLATION REACTION SEQUENCE. , 1963, Biochemistry.
[34] J. Cheng,et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas , 1995, International journal of cancer.
[35] J. Larner,et al. Insulin and Glycogen Synthase , 1972, Diabetes.
[36] A. Ullrich,et al. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity , 1988, Cell.
[37] J. Woodgett,et al. Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families. , 1991, European journal of biochemistry.
[38] David R. Kaplan,et al. Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt , 1997, Science.
[39] B. Hemmings,et al. Constitutive activation of protein kinase B and phosphorylation of p47 phox by a membrane-targeted phosphoinositide 3-kinase , 1996, Current Biology.
[40] James R. Woodgett,et al. Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells , 1996, Current Biology.
[41] R. Martuza,et al. Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma , 1986, Nature.
[42] T. Soderling,et al. Inactivation of glycogen synthetase and activation of phosphorylase kinase by muscle adenosine 3',5'-monophosphate-dependent protein kinases. , 1970, The Journal of biological chemistry.
[43] L. Stephens,et al. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils , 1991, Nature.
[44] T. Pawson,et al. SH2 and SH3 domains: From structure to function , 1992, Cell.
[45] M. Birnbaum,et al. Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation* , 1996, The Journal of Biological Chemistry.
[46] P. Cohen,et al. Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. , 1993, The Biochemical journal.
[47] P. Cohen,et al. Glycogen synthase kinase-3 from rabbit skeletal muscle. , 2005, Methods in enzymology.
[48] B. Gibson,et al. Analysis of the in vivo phosphorylation state of rabbit skeletal muscle glycogen synthase by fast-atom-bombardment mass spectrometry. , 1988, European journal of biochemistry.
[49] P. Roach,et al. Phosphorylation of Sites 3a and 3b (Ser640 and Ser644) in the Control of Rabbit Muscle Glycogen Synthase(*) , 1995, The Journal of Biological Chemistry.
[50] V. Lefebvre,et al. Signaling Pathway Involved in the Activation of Heart 6-Phosphofructo-2-kinase by Insulin* , 1996, The Journal of Biological Chemistry.
[51] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[52] S. Cohen,et al. Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. , 1980, The Journal of biological chemistry.
[53] P. Cohen,et al. The molecular mechanism by which adrenalin inhibits glycogen synthesis. , 1991, European journal of biochemistry.
[54] P. Dent,et al. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle , 1990, Nature.
[55] J. Larner,et al. Influence Of Epinephrine and Insulin on Uridine Diphosphate Glucose-α-Glucan Transferase and Phosphorylase in Muscle , 1964, Nature.
[56] P. Cohen,et al. Mechanism of activation of protein kinase B by insulin and IGF‐1. , 1996, The EMBO journal.
[57] K Y Hui,et al. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). , 1994, The Journal of biological chemistry.
[58] J. Woodgett,et al. Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation. , 1993, The EMBO journal.
[59] C. Proud,et al. Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. , 1994, The Biochemical journal.
[60] P. Cohen,et al. The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro , 1994, FEBS letters.
[61] D. Alessi,et al. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. , 1996, The Biochemical journal.
[62] J. Larner,et al. Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle. II. Some chemical characteristics of the enzyme protein and of its change on interconversion. , 1971, Biochimica et biophysica acta.
[63] G. Thomas,et al. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[64] J. Woodgett,et al. Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3. , 1992, The Biochemical journal.
[65] P. Cohen,et al. Glycogen synthase from rabbit skeletal muscle; effect of insulin on the state of phosphorylation of the seven phosphoserine residues in vivo. , 2005, European journal of biochemistry.
[66] G. Evan,et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.
[67] P. Cohen,et al. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase , 1996, FEBS letters.