Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

[1]  D. Giugliano,et al.  Metabolic Syndrome and Risk of Cancer , 2012, Diabetes Care.

[2]  D. Cai,et al.  Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response , 2014, Nature Medicine.

[3]  D. Cai,et al.  Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus , 2014, Molecular metabolism.

[4]  B. Ames,et al.  Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males , 2013, Aging cell.

[5]  D. Cai,et al.  Neuroinflammatory basis of metabolic syndrome. , 2013, Molecular metabolism.

[6]  Yimin Fang,et al.  Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice , 2013, eLife.

[7]  Erik D Herzog,et al.  Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH. , 2013, Cell metabolism.

[8]  D. Cai,et al.  Hypothalamic inflammation and GnRH in aging development , 2013, Cell cycle.

[9]  J. Pyo,et al.  Overexpression of Atg5 in mice activates autophagy and extends lifespan , 2013, Nature Communications.

[10]  R. Nixon,et al.  The role of autophagy in neurodegenerative disease , 2013, Nature Medicine.

[11]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[12]  Peter J. Keller,et al.  The Role of Oxidative Stress in Nervous System Aging , 2013, PloS one.

[13]  R. Parker,et al.  Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function , 2013, Cell.

[14]  Tiewen Liu,et al.  Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans , 2013, The EMBO journal.

[15]  D. Cai,et al.  Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH , 2013, Nature.

[16]  C. Franceschi,et al.  Oxidative stress and the ageing endocrine system , 2013, Nature Reviews Endocrinology.

[17]  P. Lips,et al.  Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study. , 2013, European journal of endocrinology.

[18]  D. Cai.  Neuroinflammation and neurodegeneration in overnutrition-induced diseases , 2013, Trends in Endocrinology & Metabolism.

[19]  J. Rhodes,et al.  Neurogenesis, inflammation and behavior , 2013, Brain, Behavior, and Immunity.

[20]  P. Lips,et al.  Serum IGF 1 , metabolic syndrome , and incident cardiovascular disease in older people : a population-based study , 2013 .

[21]  Paolo Chiodini,et al.  Metabolic Syndrome and Risk of Cancer , 2012, Diabetes Care.

[22]  Kevin W Williams,et al.  From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior , 2012, Nature Neuroscience.

[23]  C. Leeuwenburgh,et al.  Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding , 2012, AGE.

[24]  H. Krum,et al.  Sustained activation of microglia in the hypothalamic PVN following myocardial infarction , 2012, Autonomic Neuroscience.

[25]  D. Cai,et al.  IKKβ/NF-κB Disrupts Adult Hypothalamic Neural Stem Cells to Mediate Neurodegenerative Mechanism of Dietary Obesity and Pre-Diabetes , 2012, Nature Cell Biology.

[26]  G. Ruvkun,et al.  Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways , 2012, PLoS genetics.

[27]  A. Álvarez-Buylla,et al.  Adult neural stem cells bridge their niche. , 2012, Cell stem cell.

[28]  Guang-Chao Chen,et al.  Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila , 2012, Journal of Biomedical Science.

[29]  L. Velloso,et al.  Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver , 2012, Diabetes.

[30]  S. Hekimi,et al.  Superoxide dismutase is dispensable for normal animal lifespan , 2012, Proceedings of the National Academy of Sciences.

[31]  G. Fishell,et al.  Tanycytes of the Hypothalamic Median Eminence Form a Diet-Responsive Neurogenic Niche , 2012, Nature Neuroscience.

[32]  S. Woods,et al.  High-fat-diet exposure induces IgG accumulation in hypothalamic microglia , 2012, Disease Models & Mechanisms.

[33]  Xianlin Han,et al.  Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration , 2012, Journal of Lipid Research.

[34]  M. Dietrich,et al.  Obesity is associated with hypothalamic injury in rodents and humans. , 2012, The Journal of clinical investigation.

[35]  J. Flier,et al.  Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. , 2012, The Journal of clinical investigation.

[36]  Tiewen Liu,et al.  Hypothalamic inflammation: a double‐edged sword to nutritional diseases , 2011, Annals of the New York Academy of Sciences.

[37]  Jordi Oliver,et al.  Age and sex-related changes in rat brain mitochondrial oxidative status , 2011, Experimental Gerontology.

[38]  C. Glass,et al.  Microglial cell origin and phenotypes in health and disease , 2011, Nature Reviews Immunology.

[39]  D. Rubinsztein,et al.  Autophagy and Aging , 2011, Cell.

[40]  M. Dietrich,et al.  Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity , 2011, Nature Medicine.

[41]  K. Khrapko.  The timing of mitochondrial DNA mutations in aging , 2011, Nature Genetics.

[42]  J. Kaye,et al.  The aging systemic milieu negatively regulates neurogenesis and cognitive function , 2011, Nature.

[43]  D. Cai,et al.  Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway* , 2011, The Journal of Biological Chemistry.

[44]  Jennifer W. Hill,et al.  Central insulin and leptin-mediated autonomic control of glucose homeostasis , 2011, Trends in Endocrinology & Metabolism.

[45]  T. Kirkwood,et al.  Evolution of the mitochondrial fusion–fission cycle and its role in aging , 2011, Proceedings of the National Academy of Sciences.

[46]  C. Trautwein,et al.  Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation , 2011, The Journal of Immunology.

[47]  D. Cai,et al.  Uncoupling Obesity-related Hypertension by Targeting Hypothalamic IKKβ/NF-κB , 2011, Nature Medicine.

[48]  J. Argente,et al.  Activation of Microglia in Specific Hypothalamic Nuclei and the Cerebellum of Adult Rats Exposed to Neonatal Overnutrition , 2011, Journal of neuroendocrinology.

[49]  L. Missiaen,et al.  IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging , 2011, Journal of aging research.

[50]  M. Tschöp,et al.  A Role for Astrocytes in the Central Control of Metabolism , 2011, Neuroendocrinology.

[51]  A. Planas,et al.  Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways , 2011, Glia.

[52]  T. Tiganis.  Reactive oxygen species and insulin resistance: the good, the bad and the ugly. , 2011, Trends in pharmacological sciences.

[53]  D. Cai,et al.  Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress , 2011, Proceedings of the National Academy of Sciences.

[54]  Kerri M. Smith.  Neuroscience: Settling the great glia debate , 2010, Nature.

[55]  Rudolph L. Leibel,et al.  Obesity and leptin resistance: distinguishing cause from effect , 2010, Trends in Endocrinology & Metabolism.

[56]  J. Brüning,et al.  CNS leptin and insulin action in the control of energy homeostasis , 2010, Annals of the New York Academy of Sciences.

[57]  D. Rubinsztein,et al.  Regulation of mammalian autophagy in physiology and pathophysiology. , 2010, Physiological reviews.

[58]  Wenzhen Duan,et al.  Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction. , 2010, Current drug targets.

[59]  G. Halliday,et al.  Changes in key hypothalamic neuropeptide populations in Huntington disease revealed by neuropathological analyses , 2010, Acta Neuropathologica.

[60]  E. Ford,et al.  Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US * , 2010, Journal of diabetes.

[61]  T. Horvath,et al.  Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity , 2010, Proceedings of the National Academy of Sciences.

[62]  R. Xavier,et al.  Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease , 2010, Proceedings of the National Academy of Sciences.

[63]  Robert W. Williams,et al.  Metabolic Networks of Longevity , 2010, Cell.

[64]  O. Khabour,et al.  Association of longevity with IL‐10 −1082 G/A and TNF‐α−308 G/A polymorphisms , 2010, International journal of immunogenetics.

[65]  H. Krum,et al.  Microglia activation in the hypothalamic PVN following myocardial infarction , 2010, Brain Research.

[66]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[67]  V. Perry,et al.  Microglia in neurodegenerative disease , 2010, Nature Reviews Neurology.

[68]  G. Hotamisligil,et al.  Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.

[69]  A. Salmon,et al.  Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? , 2010, Free radical biology & medicine.

[70]  D. Baker,et al.  Inflammation in neurodegenerative diseases , 2010, Immunology.

[71]  J. Baik,et al.  NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia* , 2010, The Journal of Biological Chemistry.

[72]  L. Partridge,et al.  Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster , 2010, Cell metabolism.

[73]  Da-Yong Wang 王大勇,et al.  Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion , 2010, Neuroscience Bulletin.

[74]  R. Parker,et al.  Eukaryotic stress granules: the ins and outs of translation. , 2009, Molecular cell.

[75]  M. Dietrich,et al.  Feeding signals and brain circuitry , 2009, The European journal of neuroscience.

[76]  Atsushi Fukushima,et al.  Reactive oxygen species enhance insulin sensitivity. , 2009, Cell metabolism.

[77]  J. Mauer,et al.  MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. , 2009, Cell metabolism.

[78]  Tao Wang,et al.  TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease , 2009, The Journal of cell biology.

[79]  M. Cipolla,et al.  PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension. , 2009, American journal of physiology. Heart and circulatory physiology.

[80]  Marco Pahor,et al.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.

[81]  J. Friedman.  Obesity: Causes and control of excess body fat , 2009, Nature.

[82]  Nicola J. Allen,et al.  Neuroscience: Glia — more than just brain glue , 2009, Nature.

[83]  Howard Y. Chang,et al.  SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span , 2009, Cell.

[84]  Jason Chung,et al.  Endoplasmic reticulum stress plays a central role in development of leptin resistance. , 2009, Cell metabolism.

[85]  A. Contestabile.  Benefits of caloric restriction on brain aging and related pathological States: understanding mechanisms to devise novel therapies. , 2009, Current medicinal chemistry.

[86]  J. Olefsky,et al.  SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes , 2008, Molecular and Cellular Biology.

[87]  J. Yi,et al.  PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms , 2008, Brain Research.

[88]  M. Karin,et al.  Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity , 2008, Cell.

[89]  R. Klein,et al.  Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism , 2008, PLoS biology.

[90]  B. Roysam,et al.  Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. , 2008, Cell stem cell.

[91]  Tamas L. Horvath,et al.  UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals , 2008, Nature.

[92]  Linda Partridge,et al.  Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis" , 2008, Science.

[93]  M. White,et al.  Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis" , 2008, Science.

[94]  Jennifer M. A. Tullet,et al.  Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans , 2008, Cell.

[95]  A. Brech,et al.  Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila , 2008, Autophagy.

[96]  R. Seeley,et al.  The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation. , 2008, Annual review of physiology.

[97]  Heike Münzberg,et al.  Mechanisms of leptin action and leptin resistance. , 2008, Annual review of physiology.

[98]  C. Kahn,et al.  Endocrine regulation of ageing , 2007, Nature Reviews Molecular Cell Biology.

[99]  A. Mykletun,et al.  Age-specific prevalence of the metabolic syndrome defined by the International Diabetes Federation and the National Cholesterol Education Program: the Norwegian HUNT 2 study , 2007, BMC public health.

[100]  R. Youle,et al.  Mitochondrial Fission and Fusion Mediators, hFis1 and OPA1, Modulate Cellular Senescence* , 2007, Journal of Biological Chemistry.

[101]  L. Guarente,et al.  Two neurons mediate diet-restriction-induced longevity in C. elegans , 2007, Nature.

[102]  S. O’Rahilly,et al.  The Hormonal Control of Food Intake , 2007, Cell.

[103]  G. Jansen,et al.  Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. , 2007, Developmental biology.

[104]  S. Pletcher,et al.  Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors , 2007, Science.

[105]  D. Diz,et al.  Aging and the brain renin-angiotensin system: insights from studies in transgenic rats. , 2007, Cleveland Clinic journal of medicine.

[106]  N. Aziz,et al.  Hypothalamic Dysfunction and Neuroendocrine and Metabolic Alterations in Huntington Disease: Clinical Consequences and Therapeutic Implications , 2007, Reviews in the neurosciences.

[107]  G. Wilcock,et al.  The metabolic syndrome and Alzheimer disease. , 2007, Archives of neurology.

[108]  Richard Weindruch,et al.  Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program , 2007, BMC Genomics.

[109]  Raphaelle Winsky-Sommerer,et al.  Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span , 2006, Science.

[110]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[111]  M. W. Schwartz,et al.  Central nervous system control of food intake and body weight , 2006, Nature.

[112]  Masaaki Komatsu,et al.  Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.

[113]  Hideyuki Okano,et al.  Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice , 2006, Nature.

[114]  C. Geula,et al.  Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons , 2006, Nature Genetics.

[115]  S. Marklund,et al.  Phenotypes of Mice Lacking Extracellular Superoxide Dismutase and Copper- and Zinc-containing Superoxide Dismutase* , 2006, Journal of Biological Chemistry.

[116]  L. Velloso,et al.  Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. , 2005, Endocrinology.

[117]  Animesh Nandi,et al.  Suppression of Aging in Mice by the Hormone Klotho , 2005, Science.

[118]  R. Cone.  Anatomy and regulation of the central melanocortin system , 2005, Nature Neuroscience.

[119]  L. Rossetti,et al.  Hypothalamic sensing of fatty acids , 2005, Nature Neuroscience.

[120]  Robert S. Balaban,et al.  Mitochondria, Oxidants, and Aging , 2005, Cell.

[121]  C. Franceschi,et al.  Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians , 2005, Mechanisms of Ageing and Development.

[122]  Arlan Richardson,et al.  Methionine oxidation and aging. , 2005, Biochimica et biophysica acta.

[123]  A. Mark,et al.  Obesity-associated hypertension: new insights into mechanisms. , 2005, Hypertension.

[124]  H. Wootz,et al.  Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. , 2004, Biochemical and biophysical research communications.

[125]  Takashi Kudo,et al.  Induction of neuronal death by ER stress in Alzheimer’s disease , 2004, Journal of Chemical Neuroanatomy.

[126]  J. Flier,et al.  Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 , 2004, Nature Medicine.

[127]  M. Mayo,et al.  Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.

[128]  E. Stadtman.  Role of oxidant species in aging. , 2004, Current medicinal chemistry.

[129]  J. Flier,et al.  The Fat-Brain Axis Enters a New Dimension , 2004, Science.

[130]  C. Kenyon,et al.  Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons , 2004, Neuron.

[131]  T. Hastings,et al.  Biomedicine. Parkinson's--divergent causes, convergent mechanisms. , 2004, Science.

[132]  C. Epstein,et al.  Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. , 2003, Physiological genomics.

[133]  Amy N Holland,et al.  Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. , 2003, Endocrinology.

[134]  Richard A. Miller,et al.  Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[135]  S. Woods,et al.  Central nervous system control of food intake , 2000, Nature.

[136]  H. J. Kim,et al.  The effect of age on cyclooxygenase-2 gene expression: NF-kappaB activation and IkappaBalpha degradation. , 2000, Free radical biology & medicine.

[137]  Luigi Ferrucci,et al.  Serum IL‐6 Level and the Development of Disability in Older Persons , 1999, Journal of the American Geriatrics Society.

[138]  H. Cohen,et al.  Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. , 1999, The American journal of medicine.

[139]  D. Ganten,et al.  Blood pressure reduction and diabetes insipidus in transgenic rats deficient in brain angiotensinogen. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[140]  J. Halaas,et al.  Leptin and the regulation of body weight in mammals , 1998, Nature.

[141]  T. Wagner,et al.  A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[142]  S. Im,et al.  Constitutive activation of NF-kappa B in an animal model of aging. , 1997, International immunology.

[143]  B. Ames,et al.  Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[144]  A. Salminen,et al.  Age-related changes in the regulation of transcription factor NF-κB in rat brain , 1997, Neuroscience Letters.

[145]  R. Miskin,et al.  Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[146]  Andrzej Bartke,et al.  Dwarf mice and the ageing process , 1996, Nature.

[147]  S. Marklund,et al.  Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[148]  D. Price,et al.  Age‐Dependent Impairment of Mitochondrial Function in Primate Brain , 1993, Journal of neurochemistry.

[149]  A. Mooradian.  Effect of aging on the blood-brain barrier , 1988, Neurobiology of Aging.

[150]  D. Harman.  Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.