Transient Signal Intensity Enhancement in the Amniotic Fluid After Administration of a Macrocyclic Gadolinium Chelate to a Pregnant Woman

Since their implementation in clinical routine, little is known on the pharmacokinetics and effects of gadolinium (Gd) chelates on fetuses. Two experimental studies have reported the presence of Gd chelates in the amniotic fluid of gravid mice and macaques 24 hours after intravenous administration. We describe the case of a 27-week pregnant patient who underwent uterine magnetic resonance imaging (MRI) examinations after a cardiac MRI with Gd-chelate injection.