NATURAL AND SYNTHETIC POLYAMINE DERIVATIVES AS ANTAGONISTS OF GLUTAMATE RECEPTORS

The structural requirements for potent channel blocking activity are much wider than the limited spectrum prescribed by the natural products. We have described, among others, analogues in which the aromatic chromophore may be one of a range of hydroxylated phen Ipropanoic, cinnamic, or benzoic acid derivatives linked only to a polyamine. i rom the accumulated activity data, 7 hese include the nature of the aromatic residue, an apparent B y essential chain between the afore-mentioned structural features. 1y he majority of our atterns within the observed structural variations are beginnin to emerge.