Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine

With the development of cancer immunotherapy, cancer vaccine has become a novel modality for cancer treatment, and the important role of adjuvant has been realized recently. Chitin, chitosan, and their derivatives have shown their advantages as adjuvants for cancer vaccine. In this paper, the adjuvant properties of chitin and chitosan were discussed, and some detailed information about glycated chitosan and chitosan nanoparticles was also presented to illustrate the trend for future development.

[1]  S. Adams Toll-like receptor agonists in cancer therapy. , 2009, Immunotherapy.

[2]  J. Viret,et al.  Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. , 2004, Current opinion in biotechnology.

[3]  A. T. Glenny,et al.  Immunological notes. XVII–XXIV , 1926 .

[4]  E. Vavříková,et al.  Chitosan derivatives with antimicrobial, antitumour and antioxidant activities--a review. , 2011, Current pharmaceutical design.

[5]  S. Reed,et al.  Adjuvants for human vaccines. , 2012, Current opinion in immunology.

[6]  R. Nordquist,et al.  Antitumor immunity induced by laser immunotherapy and its adoptive transfer. , 2001, Cancer research.

[7]  S. Gringhuis,et al.  Signalling through C-type lectin receptors: shaping immune responses , 2009, Nature Reviews Immunology.

[8]  C. Pillai,et al.  Chitin and chitosan polymers: Chemistry, solubility and fiber formation , 2009 .

[9]  I. Azuma,et al.  Adjuvant activity of chitin derivatives in mice and guinea-pigs. , 1985, Vaccine.

[10]  J. Michalek,et al.  Evaluating Efficacy of a Chitosan Product Using a Double-Blinded, Placebo-Controlled Protocol , 2006, Journal of the American College of Nutrition.

[11]  E. Vasheghani-Farahani,et al.  Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab , 2011, International journal of nanomedicine.

[12]  A. Wetterwald,et al.  Virosomes as new carrier system for cancer vaccines , 2004, Cancer Immunology, Immunotherapy.

[13]  Xiaosong Li,et al.  Long-Term Effect on EMT6 Tumors in Mice Induced by Combination of Laser Immunotherapy and Surgery , 2011, Integrative cancer therapies.

[14]  George Coukos,et al.  Cancer immunotherapy comes of age , 2011, Nature.

[15]  V. Schijns,et al.  Mechanisms of vaccine adjuvant activity: initiation and regulation of immune responses by vaccine adjuvants. , 2003, Vaccine.

[16]  Wei R. Chen,et al.  Host antitumour immune responses to HIFU ablation , 2007, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[17]  G. Bader,et al.  Immunomodulatory and antitumoral effects of triterpenoid saponins. , 1997, Die Pharmazie.

[18]  Abdel Kareem Azab,et al.  Biocompatibility evaluation of crosslinked chitosan hydrogels after subcutaneous and intraperitoneal implantation in the rat. , 2007, Journal of biomedical materials research. Part A.

[19]  J. Synowiecki,et al.  Production, Properties, and Some New Applications of Chitin and Its Derivatives , 2003, Critical reviews in food science and nutrition.

[20]  J. Schlom,et al.  In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines. , 2011, Biomaterials.

[21]  Ravi R. Patel,et al.  Chitosan mediated targeted drug delivery system: a review. , 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[22]  N. Selvamurugan,et al.  Chitosan and its derivatives for gene delivery. , 2011, International journal of biological macromolecules.

[23]  Hong Liu,et al.  Enhancement of Laser Cancer Treatment by a Chitosan-derived Immunoadjuvant¶ , 2005, Photochemistry and photobiology.

[24]  R. Read,et al.  Effective nasal influenza vaccine delivery using chitosan. , 2005, Vaccine.

[25]  Y. Yeo,et al.  Zwitterionic Chitosan Derivative, a New Biocompatible Pharmaceutical Excipient, Prevents Endotoxin-Mediated Cytokine Release , 2012, PloS one.

[26]  J. Stern,et al.  Chitosan supplementation and fat absorption in men and women. , 2005, Journal of the American Dietetic Association.

[27]  Hong Liu,et al.  Effect of different components of laser immunotherapy in treatment of metastatic tumors in rats. , 2002, Cancer research.

[28]  J. Cebon Cancer vaccines: Where are we going? , 2010, Asia-Pacific journal of clinical oncology.

[29]  J. Elias,et al.  Chitin particles are multifaceted immune adjuvants. , 2010, American journal of respiratory and critical care medicine.

[30]  J. Elias,et al.  Chitin regulation of immune responses: an old molecule with new roles. , 2008, Current opinion in immunology.

[31]  I. Azuma,et al.  Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer. , 2003, Anticancer research.

[32]  Y. Kato,et al.  Application of chitin and chitosan derivatives in the pharmaceutical field. , 2003, Current pharmaceutical biotechnology.

[33]  Xiuli Wu,et al.  MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice , 2012, International Immunopharmacology.

[34]  Drew M. Pardoll,et al.  The blockade of immune checkpoints in cancer immunotherapy , 2012, Nature Reviews Cancer.

[35]  K. Lee,et al.  Preparation and characterization of nonaarginine-modified chitosan nanoparticles for siRNA delivery. , 2013, Carbohydrate polymers.

[36]  M Suzuki,et al.  Protecting Effect of Chitin and Chitosan on Experimentally Induced Murine Candidiasis , 1984, Microbiology and immunology.

[38]  Q. Ping,et al.  Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice. , 2008, International journal of pharmaceutics.

[39]  Yinglei Xu,et al.  Chitosan Nanoparticles Act as an Adjuvant to Promote both Th1 and Th2 Immune Responses Induced by Ovalbumin in Mice , 2011, Marine drugs.

[40]  V. Mourya,et al.  Trimethyl chitosan and its applications in drug delivery , 2009, Journal of materials science. Materials in medicine.

[41]  S. Davis,et al.  Chitosan as a novel nasal delivery system for vaccines. , 2001, Advanced drug delivery reviews.

[42]  R. Rappuoli,et al.  Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan. , 2004, Vaccine.

[43]  P. G. Seferian,et al.  Immune stimulating activity of two new chitosan containing adjuvant formulations. , 2000, Vaccine.

[44]  Jun Jie Wang,et al.  Recent advances of chitosan nanoparticles as drug carriers , 2011, International journal of nanomedicine.

[45]  C. Cluff Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. , 2010, Advances in experimental medicine and biology.

[46]  H E Junginger,et al.  Chitosan for mucosal vaccination. , 2001, Advanced drug delivery reviews.

[47]  Hong Liu,et al.  Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients , 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[48]  H. Benson,et al.  Enhanced immune response against pertussis toxoid by IgA-loaded chitosan-dextran sulfate nanoparticles. , 2012, Journal of pharmaceutical sciences.

[49]  E. Repasky,et al.  Heat shock proteins as vaccine adjuvants in infections and cancer. , 2006, Drug discovery today.

[50]  E. Montomoli,et al.  Current adjuvants and new perspectives in vaccine formulation , 2011, Expert review of vaccines.

[51]  Shuji Watanabe,et al.  Hypocholesterolemic action of chitosans with different viscosity in rats , 1988, Lipids.

[52]  R. Gupta,et al.  Adjuvants for human vaccines--current status, problems and future prospects. , 1995, Vaccine.

[53]  G. Dranoff,et al.  Combining immunotherapy and targeted therapies in cancer treatment , 2012, Nature Reviews Cancer.

[54]  B. Krajewska,et al.  Membrane-based processes performed with use of chitin/chitosan materials , 2005 .

[55]  H. Ijima,et al.  Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze-thawing, and its application in wound care. , 2012, Acta biomaterialia.

[56]  S. Gnjatic,et al.  Toll-Like Receptor Agonists: Are They Good Adjuvants? , 2010, Cancer journal.

[57]  A. Bolhassani,et al.  Heat-shock proteins as powerful weapons in vaccine development , 2008, Expert review of vaccines.

[58]  E. Oviedo-Orta,et al.  Progress in understanding adjuvant immunotoxicity mechanisms. , 2011, Toxicology letters.

[59]  J. Schlom,et al.  Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. , 2007, Vaccine.

[60]  Hong Liu,et al.  Glycated chitosan as a new non-toxic immunological stimulant , 2009, Immunopharmacology and immunotoxicology.

[61]  J Marcinkiewicz,et al.  Immunoadjuvant properties of chitosan. , 1991, Archivum immunologiae et therapiae experimentalis.

[62]  Javad Shokri,et al.  Nanovaccine for leishmaniasis: preparation of chitosan nanoparticles containing Leishmania superoxide dismutase and evaluation of its immunogenicity in BALB/c mice , 2011, International journal of nanomedicine.

[63]  Q. Myrvik,et al.  Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. , 1997, Journal of immunology.

[64]  R. Muzzarelli,et al.  Chitin Deacetylases: Properties and Applications , 2010, Marine drugs.

[65]  C. Peniche,et al.  Chitosan nanoparticles: a contribution to nanomedicine , 2011 .

[66]  G. Gao,et al.  Carbohydrate-functionalized chitosan fiber for influenza virus capture. , 2011, Biomacromolecules.

[67]  N. Sato,et al.  Heat shock proteins and immunity: Application of hyperthermia for immunomodulation , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[68]  Makiya Nishikawa,et al.  Heat shock protein derivatives for delivery of antigens to antigen presenting cells. , 2008, International journal of pharmaceutics.

[69]  I. Azuma,et al.  Stimulation of cytokine production in mice using deacetylated chitin. , 1986, Vaccine.

[70]  B. Sarmento,et al.  Chitosan-based nanoparticles as delivery systems of therapeutic proteins. , 2012, Methods in molecular biology.

[71]  F. Vogel,et al.  A compendium of vaccine adjuvants and excipients. , 1995, Pharmaceutical biotechnology.

[72]  I Saiki,et al.  Immunological activity of chitin and its derivatives. , 1984, Vaccine.

[73]  H. Tamura,et al.  Immunological aspects of chitin and chitin derivatives administered to animals. , 1999, EXS.

[74]  Qingzhen Zhao,et al.  A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis. , 2008, Vaccine.

[75]  R. Gao,et al.  A novel chitosan CpG nanoparticle regulates cellular and humoral immunity of mice. , 2006, Biomedical and environmental sciences : BES.

[76]  H. Levitsky,et al.  Towards Curative Cancer Immunotherapy: Overcoming Posttherapy Tumor Escape , 2012, Clinical & developmental immunology.

[77]  V. Brusic,et al.  Optimizing vaccine development , 2011, Cellular microbiology.

[78]  Feifan Zhou,et al.  Immunostimulatory properties of glycated chitosan. , 2011, Journal of X-ray science and technology.

[79]  J. Schlom,et al.  Intratumoral Immunotherapy of Established Solid Tumors With Chitosan/IL-12 , 2010, Journal of immunotherapy.

[80]  Hong Liu,et al.  Induced antitumor immunity against DMBA‐4 metastatic mammary tumors in rats using laser immunotherapy , 2003, International journal of cancer.

[81]  D. Jäger,et al.  Antigen‐specific immunotherapy and cancer vaccines , 2003, International journal of cancer.

[82]  Tianhong Dai,et al.  Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects , 2011, Expert review of anti-infective therapy.

[83]  Tomas Hode,et al.  Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method. , 2011, Journal of biomedical optics.

[84]  Q. Myrvik,et al.  Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice , 1997, Infection and immunity.

[85]  R. Drew,et al.  Wettability and spreading kinetics of molten aluminum on copper-coated ceramics , 2006 .

[86]  J. Y. Kim,et al.  Anti-tumor immunostimulatory effect of heat-killed tumor cells , 2008, Experimental & Molecular Medicine.

[87]  D. Chaplin,et al.  Tumor Immune Evasion , 2010, Science.

[88]  Mi-Sun Song,et al.  Preparation and Physical Properties of Chitosan Benzoic Acid Derivatives Using a Phosphoryl Mixed Anhydride System , 2012, Molecules.

[89]  J. Yeh,et al.  Antibacterial Characteristics and Activity of Water-Soluble Chitosan Derivatives Prepared by the Maillard Reaction , 2011, Molecules.

[90]  Hong Liu,et al.  Mechanism study of tumor-specific immune responses induced by laser immunotherapy , 2011, BiOS.

[91]  J. Schlom,et al.  Therapeutic cancer vaccines: current status and moving forward. , 2012, Journal of the National Cancer Institute.

[92]  A. Allison Squalene and squalane emulsions as adjuvants. , 1999, Methods.

[93]  J. Schlom,et al.  Chitosan solution enhances the immunoadjuvant properties of GM-CSF. , 2007, Vaccine.

[94]  C. Cluff Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results. , 2009, Advances in experimental medicine and biology.

[95]  C. Lee Chitin, Chitinases and Chitinase-like Proteins in Allergic Inflammation and Tissue Remodeling , 2009, Yonsei medical journal.

[96]  Anil Mahapatro,et al.  Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines , 2011, Journal of nanobiotechnology.

[97]  R. Muzzarelli,et al.  Human enzymatic activities related to the therapeutic administration of chitin derivatives , 1997, Cellular and Molecular Life Sciences CMLS.