Morphological variation of hydroxyapatite grown in aqueous solution based on simulated body fluid

We successfully controlled the morphology of hydroxyapatite (HAp) grown in a solution system based on simulated body fluid (SBF). Nanometric low-dimensional forms, such as sheets and needles elongated in the c axis, were produced with phosphate-surplus (or calcium-deficient) HAp in the solution at human body temperature. The nanoneedles were obtained on the seed crystals under gentle growth conditions at pH 6.5; the nanosheets were grown through coalescence of tiny grains or needles at a relatively high growth rate above pH 7.0. On the other hand, micrometric bulky hexagonal shapes and faceted plates of semi-stoichiometric HAp were grown under hydrothermal conditions at pH 7.0 and 7.4, respectively. The variation of the morphology is discussed on the basis of the change of the growth mode of HAp crystals depending on the supersaturated conditions.

[1]  J. Gómez-Morales,et al.  Formation of calcium phosphates by vapour diffusion in highly concentrated ionic micro‐droplets , 2011 .

[2]  N. Watanabe,et al.  Hydrothermal synthesis and characterization of hydroxyapatite from octacalcium phosphate , 2010 .

[3]  Y. Oaki,et al.  Fibrous nanocrystals of hydroxyapatite loaded with TiO(2) nanoparticles for the capture and photocatalytic decomposition of specific proteins. , 2010, Colloids and surfaces. B, Biointerfaces.

[4]  S. Ogata,et al.  Sensing of protein adsorption with a porous bulk composite comprising silver nanoparticles deposited on hydroxyapatite , 2010, Journal of materials science. Materials in medicine.

[5]  M. K. Sinha,et al.  Bone-like growth of hydroxyapatite in the biomimetic coating of Ti-6Al-4V alloy pretreated with protein at 25 °C , 2009 .

[6]  K. Kikuta,et al.  Formation of needle-like hydroxyapatite by hydrothermal treatment of CaHPO4·2H2O combined with β-Ca3(PO4)2 , 2009 .

[7]  M. Yoshimura,et al.  An Effective Morphology Control of Hydroxyapatite Crystals via Hydrothermal Synthesis , 2009 .

[8]  B. Viswanath,et al.  Controlled synthesis of plate-shaped hydroxyapatite and implications for the morphology of the apatite phase in bone. , 2008, Biomaterials.

[9]  H. Engqvist,et al.  Hydroxylapatite growth on single-crystal rutile substrates. , 2008, Biomaterials.

[10]  M. Yoshimura,et al.  Hydrothermal synthesis of hydroxyapatite whiskers with sharp faceted hexagonal morphology , 2008 .

[11]  Y. Oaki,et al.  Selective synthesis of various nanoscale morphologies of hydroxyapatite via an intermediate phase , 2008 .

[12]  Deping Wang,et al.  Preparation of hydroxyapatite porous ceramics with different porous structures using a hydrothermal treatment with different aqueous solutions( Ceramics for Biomedical Applications in Asian Countries) , 2008 .

[13]  Elliot P. Douglas,et al.  Bone structure and formation: A new perspective , 2007 .

[14]  K. Kandori,et al.  Microcalorimetric study of protein adsorption onto calcium hydroxyapatites. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[15]  Tadashi Kokubo,et al.  How useful is SBF in predicting in vivo bone bioactivity? , 2006, Biomaterials.

[16]  S. Goto,et al.  Hydrothermal preparation of tailored hydroxyapatite , 2006 .

[17]  K. Itatani,et al.  Syntheses of calcium-deficient apatite fibres by a homogeneous precipitation method and their characterizations , 2006 .

[18]  T. Aoba,et al.  Solubility properties of human tooth mineral and pathogenesis of dental caries. , 2004, Oral diseases.

[19]  J. Tanaka,et al.  Fabrication of hydroxyapatite sintered bodies with c axis orientation , 2003 .

[20]  S. Koutsopoulos,et al.  Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods. , 2002, Journal of biomedical materials research.

[21]  J. Evans,et al.  High Porosity Hydroxyapatite Foam Scaffolds for Bone Substitute , 2002 .

[22]  S. Goto,et al.  Hydrothermal preparation of fibrous apatite and apatite sheet , 2002 .

[23]  Pierre Layrolle,et al.  Synthesis of macroporous hydroxyapatite scaffolds for bone tissue engineering. , 2002, Journal of biomedical materials research.

[24]  Junzo Tanaka,et al.  Crystal Orientation of Hydroxyapatite Induced by Ordered Carboxyl Groups. , 2001, Journal of colloid and interface science.

[25]  M. Ozawa,et al.  Preparation of needle-like hydroxyapatite , 1998 .

[26]  P. Brown,et al.  Reactions of octacalcium phosphate to form hydroxyapatite , 1996 .

[27]  M. Yoshimura,et al.  Hydrothermal synthesis of biocompatible whiskers , 1994, Journal of Materials Science.

[28]  L. Hench,et al.  Solution effects on the surface reactions of a bioactive glass. , 1993, Journal of biomedical materials research.

[29]  P. Brown,et al.  Variations in Solution Chemistry During the Low‐Temperature Formation of Hydroxyapatite , 1991 .

[30]  T. Kawasaki Hydroxyapatite as a liquid chromatographic packing , 1991 .

[31]  P. Brown,et al.  Kinetics of Hydroxyapatite Formation at Low Temperature , 1991 .

[32]  T Kitsugi,et al.  Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[33]  T Kitsugi,et al.  Ca,P-rich layer formed on high-strength bioactive glass-ceramic A-W. , 1990, Journal of biomedical materials research.

[34]  Stephen Mann,et al.  Molecular recognition in biomineralization , 1988, Nature.