Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading.
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W. Koch | J. Keys | A. Jakoi | B. Lima | C. Milano | J. Petrofski | B. Blaxall | J. A. Hata | Matthew L. Williams | J. Schroder
[1] D. Leosco,et al. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. , 2005, European heart journal.
[2] David M. Harris,et al. Vascular Smooth Muscle Overexpression of G Protein–Coupled Receptor Kinase 5 Elevates Blood Pressure, Which Segregates With Sex and Is Dependent on Gi-Mediated Signaling , 2005, Circulation.
[3] Joshua M Hare,et al. Molecular signature analysis: using the myocardial transcriptome as a biomarker in cardiovascular disease. , 2005, Trends in cardiovascular medicine.
[4] D. Burkhoff,et al. Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties. , 2005, Journal of the American College of Cardiology.
[5] M. Boerries,et al. Cardiac adenoviral S100A1 gene delivery rescues failing myocardium. , 2004, The Journal of clinical investigation.
[6] W. Koch,et al. Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization. , 2004, Journal of molecular and cellular cardiology.
[7] Xinqiang Han,et al. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. , 2004, Physiological genomics.
[8] M. Oz,et al. Ventricular Assist Devices as a Bridge to Transplant or Recovery , 2004, Cardiology.
[9] O. Brodde. β-Adrenergic receptors in failing human myocardium , 2004, Basic Research in Cardiology.
[10] Differential regulation of Ca2+-dependent ATPase-activity in left ventricular myocardium during mechanical circulatory support. , 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
[11] L. Miller,et al. Alterations of gene expression in failing myocardium following left ventricular assist device support. , 2003, Physiological genomics.
[12] M. Yacoub,et al. Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy. , 2003, European heart journal.
[13] M. Yacoub,et al. Bridge to recovery with the use of left ventricular assist device and clenbuterol. , 2003, The Annals of thoracic surgery.
[14] W. Koch,et al. Differential gene expression and genomic patient stratification following left ventricular assist device support. , 2003, Journal of the American College of Cardiology.
[15] D. Bainbridge,et al. Cardiopulmonary Bypass Decreases G Protein–Coupled Receptor Kinase Activity and Expression in Human Peripheral Blood Mononuclear Cells , 2003, Anesthesiology.
[16] O. Frazier,et al. Downregulation of Metabolic Gene Expression in Failing Human Heart before and after Mechanical Unloading , 2002, Cardiology.
[17] A. Gerdes,et al. Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure–Prone Rats , 2002, Hypertension.
[18] Robert J. Lefkowitz,et al. Seven-transmembrane-spanning receptors and heart function , 2002, Nature.
[19] G. Andersen,et al. Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats. , 2001, American journal of physiology. Heart and circulatory physiology.
[20] A. Feldman,et al. Downregulation of Matrix Metalloproteinases and Reduction in Collagen Damage in the Failing Human Heart After Support With Left Ventricular Assist Devices , 2001, Circulation.
[21] N. Smedira,et al. Mechanical Unloading Restores &bgr;-Adrenergic Responsiveness and Reverses Receptor Downregulation in the Failing Human Heart , 2001, Circulation.
[22] N. Smedira,et al. Mechanical unloading causes recovery of calcium cycling in the failing human heart. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
[23] N. Smedira,et al. Evolution and significance of HLA allosensitization during ventricular assist device support. , 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
[24] D. Burkhoff,et al. Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure , 2000, Circulation.
[25] R. Lefkowitz,et al. Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction , 2000 .
[26] J. Holtz,et al. Myocardial gene expression of regulators of myocyte apoptosis and myocyte calcium homeostasis during hemodynamic unloading by ventricular assist devices in patients with end-stage heart failure. , 1999, Circulation.
[27] G. Noon,et al. Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support : A potential mechanism for cardiac recovery. , 1999, Circulation.
[28] M. Cho,et al. Defective β-Adrenergic Receptor Signaling Precedes the Development of Dilated Cardiomyopathy in Transgenic Mice with Calsequestrin Overexpression* , 1999, The Journal of Biological Chemistry.
[29] D. Glower,et al. Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction. , 1999, American journal of physiology. Heart and circulatory physiology.
[30] R. Lefkowitz,et al. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. , 1998, Circulation.
[31] Jv Booth. Acute depression of myocardial β-adrenergic receptor signaling during cardiopulmonary bypass , 1998 .
[32] S. Houser,et al. Regression of cellular hypertrophy after left ventricular assist device support. , 1998, Circulation.
[33] S. Houser,et al. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. , 1998, Circulation.
[34] J. Ross,et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[35] P. Ping,et al. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. , 1997, The American journal of physiology.
[36] M. Oz,et al. Circulatory resuscitation with left ventricular assist device support reduces interleukins 6 and 8 levels. , 1997, The Annals of thoracic surgery.
[37] R. Smiley,et al. Perioperative lymphocyte adenylyl cyclase function in the pediatric cardiac surgical patient. , 1996, Critical care medicine.
[38] N. Dzimiri,et al. RELATIONSHIP BETWEEN ALTERATIONS IN LYMPHOCYTE AND MYOCARDIAL β‐ADRENOCEPTOR DENSITY IN PATIENTS WITH LEFT HEART VALVULAR DISEASE , 1996, Clinical and experimental pharmacology & physiology.
[39] H Harasaki,et al. Left ventricular echocardiographic and histologic changes: impact of chronic unloading by an implantable ventricular assist device. , 1996, Journal of the American College of Cardiology.
[40] J. Thomas,et al. Effect of the implantable left ventricular assist device on neuroendocrine activation in heart failure. , 1995, Circulation.
[41] R. Lefkowitz,et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. , 1995, Science.
[42] H Harasaki,et al. Structural and left ventricular histologic changes after implantable LVAD insertion. , 1995, The Annals of thoracic surgery.
[43] M. Böhm,et al. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. , 1994, Circulation research.
[44] R. Lefkowitz,et al. Structure and mechanism of the G protein-coupled receptor kinases. , 1993, The Journal of biological chemistry.
[45] M. Böhm,et al. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. , 1993, Circulation.
[46] O. Brodde,et al. Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density. , 1986, Science.
[47] D C Harrison,et al. Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. , 1982, The New England journal of medicine.