Stability of niosomes with encapsulated vitamin D3 and ferrous sulfate generated using a novel supercritical carbon dioxide method

Abstract Niosomes were prepared using a novel supercritical carbon dioxide based method to simultaneously encapsulate ferrous sulfate and vitamin D3 as hydrophilic and hydrophobic cargo, respectively. Vesicle particle size was determined to be bimodal with peak diameters of 1.44 ± 0.16 μm and 7.21 ± 0.64 μm, with the smaller peak comprising 98.8% of the total niosomal volume. Encapsulation efficiency of ferrous sulfate was 25.1 ± 0.2% and encapsulation efficiency of vitamin D3 was 95.9 ± 1.47%. Physical stability of the produced niosomes was assessed throughout a storage period of 21 days. Niosomes showed good physical stability at 20 °C, but storage at 4 °C showed an initial burst release, indicating possible rupture of the niosomal membrane. The Korsmeyer–Peppas equation was used to model the release of ferrous sulfate over time at both storage temperatures.

[1]  A. Cilla,et al.  Iron bioavailability in iron-fortified cereal foods: The contribution of in vitro studies , 2017, Critical reviews in food science and nutrition.

[2]  K. Khosravi‐Darani,et al.  Application of Liposomes in Some Dairy Products , 2016, Critical reviews in food science and nutrition.

[3]  S. Rizvi,et al.  Novel method of niosome generation using supercritical carbon dioxide part I: process mechanics , 2015, Journal of liposome research.

[4]  M. Mohammadi,et al.  Physical properties of vitamin D3-loaded nanoliposomes prepared by thin layer hydration-sonication. , 2014 .

[5]  Harjinder Singh,et al.  Structure and integrity of liposomes prepared from milk- or soybean-derived phospholipids during in vitro digestion , 2012 .

[6]  M. R. Mozafari,et al.  Nanoencapsulation of food ingredients using lipid based delivery systems , 2012 .

[7]  N. Chiaramoni,et al.  Liposomes as vehicles for vitamins E and C: An alternative to fortify orange juice and offer vitamin C protection after heat treatment , 2011 .

[8]  Nicholas A Peppas,et al.  Higuchi equation: derivation, applications, use and misuse. , 2011, International journal of pharmaceutics.

[9]  O. Boutin,et al.  CO2/water/surfactant ternary systems and liposome formation using supercritical CO2: a review , 2011 .

[10]  N. Yuksel,et al.  Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery. , 2010, Journal of pharmaceutical sciences.

[11]  J. Manosroi,et al.  Characteristics of niosomes entrapped with rice bran bioactive compounds prepared by supercritical carbon dioxide , 2010, 2010 International Conference on Nanoscience and Nanotechnology.

[12]  F. Dehghani,et al.  The depressurization of an expanded solution into aqueous media for the bulk production of liposomes. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[13]  M. J. Cocero,et al.  Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications , 2009 .

[14]  G. Jensen,et al.  An Improved Cryogen for Plunge Freezing , 2008, Microscopy and Microanalysis.

[15]  D. Rousseau,et al.  Vitamin D3 fortification, quantification, and long-term stability in Cheddar and low-fat cheeses. , 2008, Journal of agricultural and food chemistry.

[16]  V. Junyaprasert,et al.  Effect of Charged and Non-ionic Membrane Additives on Physicochemical Properties and Stability of Niosomes , 2008, AAPS PharmSciTech.

[17]  J. Manosroi,et al.  Characteristics of niosomes prepared by supercritical carbon dioxide (scCO2) fluid. , 2008, International journal of pharmaceutics.

[18]  N. Mortada,et al.  Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. , 2008, Journal of microencapsulation.

[19]  J. Weiss,et al.  Liposomal Nanocapsules in Food Science and Agriculture , 2005, Critical reviews in food science and nutrition.

[20]  Shiying Xu,et al.  Ferrous sulfate liposomes: preparation, stability and application in fluid milk , 2005 .

[21]  J. Weiss,et al.  Encapsulation of nisin and lysozyme in liposomes enhances efficacy against Listeria monocytogenes. , 2004, Journal of food protection.

[22]  Markus Antonietti,et al.  Vesicles and Liposomes: A Self‐Assembly Principle Beyond Lipids , 2003 .

[23]  B. Keller.  Liposomes in nutrition , 2001 .

[24]  C. Lacroix,et al.  Comparison of different methods for fortifying Cheddar cheese with vitamin D , 2000 .

[25]  K. Edwards,et al.  Optimization of Drug Loading Procedures and Characterization of Liposomal Formulations of Two Novel Agents Intended for Boron Neutron Capture Therapy (BNCT) , 1999 .

[26]  P. Buseck,et al.  Ratios of ferrous to ferric iron from nanometre-sized areas in minerals , 1998, Nature.

[27]  P. Cunniff.  Official Methods of Analysis of AOAC International , 2019 .

[28]  R. Fassihi,et al.  Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics. , 1997, Journal of pharmaceutical sciences.

[29]  G. Brunner,et al.  Solubilities of the Fat-Soluble Vitamins A, D, E, and K in Supercritical Carbon Dioxide , 1997 .

[30]  C. Colliex,et al.  Electron-energy-loss-spectroscopy near-edge fine structures in the iron-oxygen system. , 1991, Physical review. B, Condensed matter.

[31]  A. Raudino,et al.  THERMAL-EXPANSION AND COMPRESSIBILITY COEFFICIENTS OF PHOSPHOLIPID-VESICLES - EXPERIMENTAL-DETERMINATION AND THEORETICAL MODELING , 1990 .

[32]  D. H. Everett.  Basic Principles of Colloid Science , 1988 .

[33]  Nicholas A. Peppas,et al.  A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs , 1987 .

[34]  N. Peppas,et al.  Mechanisms of solute release from porous hydrophilic polymers , 1983 .

[35]  T. Higuchi.  MECHANISM OF SUSTAINED-ACTION MEDICATION. THEORETICAL ANALYSIS OF RATE OF RELEASE OF SOLID DRUGS DISPERSED IN SOLID MATRICES. , 1963, Journal of pharmaceutical sciences.

[36]  A. W. Hixson,et al.  Dependence of Reaction Velocity upon surface and Agitation , 1931 .