Entecavir competitively inhibits deoxyguanosine and deoxyadenosine phosphorylation in isolated mitochondria and the perfused rat heart

[1]  Miguel Ángel Martín,et al.  Recurrent rhabdomyolysis and exercise intolerance: A new phenotype of late-onset thymidine kinase 2 deficiency , 2021, Molecular genetics and metabolism reports.

[2]  D. Dimmock,et al.  The nucleotide prodrug CERC‐913 improves mtDNA content in primary hepatocytes from DGUOK‐deficient rats , 2020, Journal of inherited metabolic disease.

[3]  Xiao-Dong Luo,et al.  Mitochondrial Deoxyguanosine Kinase Regulates NAD+ Biogenesis Independent of Mitochondria Complex I Activity , 2020, Frontiers in Oncology.

[4]  A. Dhawan,et al.  Hyperinsulinaemic hypoglycaemia in deoxyguanosine kinase deficiency , 2019, Clinical endocrinology.

[5]  P. Singh,et al.  The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma , 2019, EMBO molecular medicine.

[6]  J. Arenas,et al.  Late-onset thymidine kinase 2 deficiency: a review of 18 cases , 2019, Orphanet Journal of Rare Diseases.

[7]  Entecavir , 2018, Reactions Weekly.

[8]  Robert W. Taylor,et al.  Retrospective natural history of thymidine kinase 2 deficiency , 2018, Journal of Medical Genetics.

[9]  A. Janecke,et al.  Severe DGUOK Deficiency in Austria: A Six-Patient Series. , 2018, Journal of pediatric gastroenterology and nutrition.

[10]  F. Scaglia,et al.  Mitochondrial cytopathies. , 2016, Cell calcium.

[11]  E. McKee,et al.  Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model , 2015, Antimicrobial Agents and Chemotherapy.

[12]  F. Alehan,et al.  Novel Deoxyguanosine Kinase Gene Mutations in the Hepatocerebral Form of Mitochondrial DNA Depletion Syndrome , 2015, Journal of child neurology.

[13]  E. McKee,et al.  Heart Mitochondrial TTP Synthesis and the Compartmentalization of TMP* , 2014, The Journal of Biological Chemistry.

[14]  S. Eriksson,et al.  Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs. , 2014, Biochemical and biophysical research communications.

[15]  V. Emmanuele,et al.  Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency , 2014, EMBO molecular medicine.

[16]  M. Hirano,et al.  Administration of deoxyribonucleosides or inhibition of their catabolism as a pharmacological approach for mitochondrial DNA depletion syndrome. , 2014, Human molecular genetics.

[17]  V. Wong,et al.  Entecavir treatment reduces hepatic events and deaths in chronic hepatitis B patients With liver cirrhosis , 2013, Hepatology.

[18]  Z. Duan,et al.  [Entecavir treatment causes injury to the mitochondrial DNA of peripheral blood mononuclear cells]. , 2012, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.

[19]  P. Chinnery,et al.  In vitro supplementation with deoxynucleoside monophosphates rescues mitochondrial DNA depletion. , 2012, Molecular genetics and metabolism.

[20]  E. McKee,et al.  Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria , 2012, Journal of neurochemistry.

[21]  L. Wheeler,et al.  Nucleoside Triphosphate Pool Asymmetry in Mammalian Mitochondria* , 2011, The Journal of Biological Chemistry.

[22]  M. Osborn.  Safety and efficacy of entecavir for the treatment of chronic hepatitis B , 2011, Infection and drug resistance.

[23]  G. Morris,et al.  Pyrimidine deoxynucleoside and nucleoside reverse transcriptase inhibitor metabolism in the perfused heart and isolated mitochondria , 2010, Antiviral therapy.

[24]  Ching-Lung Lai,et al.  Entecavir treatment for up to 5 years in patients with hepatitis B e antigen–positive chronic hepatitis B , 2010, Hepatology.

[25]  U. Mihm,et al.  Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function , 2009, Hepatology.

[26]  Joseph C. Ahn,et al.  Fatal lactic acidosis associated with the use of combination oral medications to treat reactivation of hepatitis B. , 2009, Journal of clinical gastroenterology.

[27]  G. Morris,et al.  Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity. , 2009, The Biochemical journal.

[28]  P. Chinnery,et al.  In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes. , 2009, Human molecular genetics.

[29]  G. Keating,et al.  Entecavir , 2012, Drugs.

[30]  Ann Saada.  Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency. , 2008, Molecular genetics and metabolism.

[31]  A. Karlsson,et al.  Human UMP-CMP Kinase 2, a Novel Nucleoside Monophosphate Kinase Localized in Mitochondria* , 2008, Journal of Biological Chemistry.

[32]  R. Hamatake,et al.  Entecavir for Treatment of Hepatitis B Virus Displays No In Vitro Mitochondrial Toxicity or DNA Polymerase Gamma Inhibition , 2007, Antimicrobial Agents and Chemotherapy.

[33]  Delia Susan-Resiga,et al.  Zidovudine Inhibits Thymidine Phosphorylation in the Isolated Perfused Rat Heart , 2007, Antimicrobial Agents and Chemotherapy.

[34]  C. Mathews.  DNA precursor metabolism and genomic stability , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  A. T. Bentley,et al.  3'-Azido-3'-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity. , 2006, Biochemical pharmacology.

[36]  Ann Saada.  Deoxyribonucleotides and disorders of mitochondrial DNA integrity. , 2004, DNA and cell biology.

[37]  A. Karlsson,et al.  Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases , 2003, Pharmacology & Therapeutics.

[38]  J. Muddle,et al.  Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts. , 2003, Human molecular genetics.

[39]  S. Dimauro,et al.  Mitochondrial DNA depletion and dGK gene mutations , 2002, Annals of neurology.

[40]  H. Mandel,et al.  Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy , 2001, Nature Genetics.

[41]  H. Eklund,et al.  Structural basis for substrate specificities of cellular deoxyribonucleoside kinases , 2001, Nature Structural Biology.

[42]  R. Furneaux,et al.  Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[43]  P. Egli,et al.  Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus , 1999, Antimicrobial Agents and Chemotherapy.

[44]  S. Eriksson,et al.  Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs. , 1998, Molecular pharmacology.

[45]  T. Podzuweit,et al.  Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine. , 1995, Cellular signalling.

[46]  M. Dalakas,et al.  Mitochondrial toxicity of antiviral drugs , 1995, Nature Medicine.

[47]  Elias S. J. Arnér,et al.  Mammalian deoxyribonucleoside kinases. , 1995, Pharmacology & therapeutics.

[48]  Elias S. J. Arnér,et al.  Substrate specificity of mitochondrial 2'-deoxyguanosine kinase. Efficient phosphorylation of 2-chlorodeoxyadenosine. , 1993, The Journal of biological chemistry.

[49]  M. Dalakas,et al.  Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[50]  E. McKee,et al.  Coupling of mitochondrial metabolism and protein synthesis in heart mitochondria. , 1990, The American journal of physiology.

[51]  E. McKee,et al.  Isolation and incubation conditions to study heart mitochondrial protein synthesis. , 1990, The American journal of physiology.

[52]  F. Snyder,et al.  Kinetic considerations for the regulation of adenosine and deoxyadenosine metabolism in mouse and human tissues based on a thymocyte model. , 1982, Biochimica et biophysica acta.