Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
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Rana A K Singh | K. Slawin | D. Spencer | B. Hanks | Weitao Song | M. H. Huls | Michael Barry | Jianghong Jiang | Rana A. K. Singh | David M. Spencer | Mary H Huls | Kevin M Slawin
[1] K. Nakai,et al. [Controlling signal transduction with synthetic ligands]. , 2007, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[2] A. Awasthi,et al. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses , 2004, Nature Medicine.
[3] D. Pardoll,et al. Persistent Toll-like receptor signals are required for reversal of regulatory T cell–mediated CD8 tolerance , 2004, Nature Immunology.
[4] C. Ahonen,et al. Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN , 2004, The Journal of experimental medicine.
[5] S. Nagata,et al. Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling. , 2003, The Journal of biological chemistry.
[6] R. Zamoyska,et al. Regulation of peripheral T-cell homeostasis by receptor signalling. , 2003, Current opinion in immunology.
[7] W. Daniel,et al. Upregulation of CD40-CD40 Ligand (CD154) in Patients With Acute Cerebral Ischemia , 2003, Stroke.
[8] E. Pamer,et al. Feedback regulation of pathogen-specific T cell priming. , 2003, Immunity.
[9] D. Ridgway. The First 1000 Dendritic Cell Vaccinees , 2003, Cancer investigation.
[10] Ranjeny Thomas,et al. Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. , 2003, Immunity.
[11] Ranjeny Thomas,et al. CD40 Ligation Conditions Dendritic Cell Antigen-Presenting Function Through Sustained Activation of NF-κB1 , 2002, The Journal of Immunology.
[12] R. Hynes,et al. CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism , 2002, Nature Medicine.
[13] Michael A. Barry,et al. The Role of T Cell Antagonism and Original Antigenic Sin in Genetic Immunization , 2002 .
[14] C. Uyttenhove,et al. CD40 triggering increases the efficiency of dendritic cells for antitumoral immunization. , 2002, Cancer immunity.
[15] R. Darnell,et al. Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells , 2001, Nature Immunology.
[16] B. Coombes,et al. Dendritic cell discoveries provide new insight into the cellular immunobiology of DNA vaccines. , 2001, Immunology letters.
[17] T. Clackson,et al. Intravenous Safety and Pharmacokinetics of a Novel Dimerizer Drug, AP1903, in Healthy Volunteers , 2001, Journal of clinical pharmacology.
[18] Frank O. Nestle,et al. Dendritic cells: On the move from bench to bedside , 2001, Nature Medicine.
[19] J. Gribben,et al. Phase I study of recombinant human CD40 ligand in cancer patients. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[20] A. Kaykas,et al. CD40 and LMP‐1 both signal from lipid rafts but LMP‐1 assembles a distinct, more efficient signaling complex , 2001, The EMBO journal.
[21] H. Waldmann,et al. Regulation of CD40 function by its isoforms generated through alternative splicing. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[22] C. Reis e Sousa,et al. Dendritic cells as sensors of infection. , 2001, Immunity.
[23] F. Sallusto,et al. Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. , 2000, Science.
[24] A. Sher,et al. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. , 2000, Immunity.
[25] F. Sallusto,et al. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells , 2000, Nature Immunology.
[26] A. Siegbahn,et al. Role of Platelet P-Selectin and CD40 Ligand in the Induction of Monocytic Tissue Factor Expression , 2000, Arteriosclerosis, thrombosis, and vascular biology.
[27] R. Crystal,et al. Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors. , 2000, Blood.
[28] Claudia Mauri,et al. Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process , 2000, Nature Medicine.
[29] Joanna M. Roberts,et al. CD8+ T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor Immunity1 , 2000, The Journal of Immunology.
[30] Jianping Yang,et al. CD8 T Cell-Dependent Elimination of Dendritic Cells In Vivo Limits the Induction of Antitumor Immunity , 2000 .
[31] D. Mukhopadhyay,et al. Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. , 2000, Blood.
[32] A. Sher,et al. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology. , 1999, Immunity.
[33] M. Daemen,et al. Requirement for CD154 in the progression of atherosclerosis , 1999, Nature Medicine.
[34] T. Schumacher,et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy , 1999, Nature Medicine.
[35] M. Kehry,et al. CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs) , 1999, The Journal of Biological Chemistry.
[36] Shannon R. Magari,et al. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[37] P. Libby,et al. Reduction of atherosclerosis in mice by inhibition of CD40 signalling , 1998, Nature.
[38] Polly Matzinger,et al. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell , 1998, Nature.
[39] Richard A. Flavell,et al. Help for cytotoxic-T-cell responses is mediated by CD40 signalling , 1998, Nature.
[40] Stephen P. Schoenberger,et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions , 1998, Nature.
[41] R. Steinman,et al. Dendritic cells and the control of immunity , 1998, Nature.
[42] R. Flavell,et al. CD40 and CD154 in cell-mediated immunity. , 1998, Annual review of immunology.
[43] G. Thomas,et al. Nuclear localization of RelB is associated with effective antigen-presenting cell function. , 1997, Journal of immunology.
[44] M. Foti,et al. Retroviral immortalization of phagocytic and dendritic cell clones as a tool to investigate functional heterogeneity. , 1994, Journal of immunological methods.
[45] R. Steinman,et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.