Infectious disease emergencies in returning travelers: special reference to malaria, dengue fever, and chikungunya.

This review article discusses important infectious illnesses, namely malaria, dengue, and chikungunya, in travelers returning from endemic areas. Malaria and dengue are two of the most common systemic illnesses reported in returning travelers. Because chikungunya is gaining importance, it is also briefly discussed. The clinical significance of these diseases is mainly due to the possibility of sudden deterioration with high mortality in clinically healthy looking patients. The key clinical features, their diagnosis, and treatment algorithms are discussed in detail to help in early diagnosis and appropriate clinical management of such travelers presenting in emergency departments.

[1]  Mary E. Wilson,et al.  Chikungunya fever: an epidemiological review of a re-emerging infectious disease. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  D. Church,et al.  Use of Molecular Beacon Probes for Real-Time PCR Detection of Plasmodium falciparum and Other Plasmodium Species in Peripheral Blood Specimens , 2006, Journal of Clinical Microbiology.

[3]  Jonathan J Deeks,et al.  Rapid diagnostic tests for diagnosing uncomplicated P. falciparum malaria in endemic countries. , 2011, The Cochrane database of systematic reviews.

[4]  M. Laufer,et al.  Dengue-related deaths in Puerto Rico, 1992-1996: diagnosis and clinical alarm signals. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  D. Conway,et al.  A large focus of naturally acquired Plasmodium knowlesi infections in human beings , 2004, The Lancet.

[6]  G. Malavige,et al.  Dengue viral infections , 2004, Postgraduate Medical Journal.

[7]  D. Conway,et al.  Plasmodium knowlesi: Reservoir Hosts and Tracking the Emergence in Humans and Macaques , 2011, PLoS pathogens.

[8]  Timothy William,et al.  Severe Plasmodium knowlesi Malaria in a Tertiary Care Hospital, Sabah, Malaysia , 2011, Emerging infectious diseases.

[9]  A. Spiegel,et al.  Ineffectiveness of the Binax NOW Malaria Test for Diagnosis of Plasmodium ovale Malaria , 2005, Journal of Clinical Microbiology.

[10]  C. Daniel-Ribeiro,et al.  Malaria diagnosis: standardization of a polymerase chain reaction for the detection of Plasmodium falciparum parasites in individuals with low-grade parasitemia , 1996, Parasitology Research.

[11]  Eric Carle From Head to Toe , 1997 .

[12]  Mary E. Wilson,et al.  Fever in returned travelers: results from the GeoSentinel Surveillance Network. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  A. Palit,et al.  Cutaneous manifestations of chikungunya fever: observations made during a recent outbreak in south India , 2008, International journal of dermatology.

[14]  Clinton K. Murray,et al.  Update on Rapid Diagnostic Testing for Malaria , 2008, Clinical Microbiology Reviews.

[15]  T. Jelínek,et al.  Clinical features and pitfalls in the laboratory diagnosis of dengue in travellers , 2006, BMC infectious diseases.

[16]  E. Schwartz Study of Dengue Fever among Israeli Travellers to Thailand , 2003 .

[17]  V. Deubel,et al.  Enzyme-Linked Immunosorbent Assay Specific to Dengue Virus Type 1 Nonstructural Protein NS1 Reveals Circulation of the Antigen in the Blood during the Acute Phase of Disease in Patients Experiencing Primary or Secondary Infections , 2002, Journal of Clinical Microbiology.

[18]  C. Drosten,et al.  Chikungunya Fever in Travelers Returning to Europe from the Indian Ocean Region, 2006 , 2008, Emerging infectious diseases.

[19]  Kamolrat Silamut,et al.  Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial , 2010, The Lancet.

[20]  田村 大輔,et al.  Centers for Disease Control and Prevention(CDC)での生活 , 2013 .

[21]  A. Powers,et al.  Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. , 2007, The Journal of general virology.

[22]  S. G Evaluation of a Dengue NS1 capture ELISA assay for the rapid detection of Dengue. , 2007 .

[23]  R. DeFraites,et al.  Dengue fever in US military personnel in Haiti. , 1997, JAMA.

[24]  I. Schuffenecker,et al.  [Vertical maternal fetal transmission of the chikungunya virus. Ten cases among 84 pregnant women]. , 2006, Presse medicale.

[25]  Cameron P. Simmons,et al.  Current concepts: Dengue , 2012 .

[26]  M. Parise,et al.  Treatment of malaria in the United States: a systematic review. , 2007, JAMA.

[27]  R. Lanciotti,et al.  Chikungunya Virus in US Travelers Returning from India, 2006 , 2007, Emerging infectious diseases.

[28]  I. Kurane,et al.  Specific IgM and IgG responses in primary and secondary dengue virus infections determined by enzyme-linked immunosorbent assay , 2005, Epidemiology and Infection.

[29]  A. Flahault,et al.  Impact of Chikungunya Virus Infection on Health Status and Quality of Life: A Retrospective Cohort Study , 2009, PloS one.

[30]  T. Wellems,et al.  Plasmodium Species (Malaria) , 2010 .

[31]  P. Chiodini,et al.  New guidelines on malaria prevention: A summary. , 2007, The Journal of infection.

[32]  S. Hoffman,et al.  Primaquine therapy for malaria. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[33]  P. Shu,et al.  Current Advances in Dengue Diagnosis , 2004, Clinical Diagnostic Laboratory Immunology.

[34]  Didier Fontenille,et al.  Two Chikungunya Isolates from the Outbreak of La Reunion (Indian Ocean) Exhibit Different Patterns of Infection in the Mosquito, Aedes albopictus , 2007, PloS one.

[35]  A. Nisalak,et al.  An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. , 1989, The American journal of tropical medicine and hygiene.

[36]  M. Landini,et al.  Chikungunya: an emerging and spreading arthropod-borne viral disease. , 2009, Journal of infection in developing countries.

[37]  A. Barrett,et al.  Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis) , 2010 .

[38]  R. Césaire,et al.  Evaluation of an Enzyme Immunoassay for Detection of Dengue Virus NS1 Antigen in Human Serum , 2006, Clinical and Vaccine Immunology.

[39]  I. Kurane,et al.  Analysis of specific IgM responses in secondary dengue virus infections: levels and positive rates in comparison with primary infections. , 2004, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[40]  N. Bhadelia,et al.  The HIV-positive traveler. , 2007, The American journal of medicine.

[41]  P. Young,et al.  An Antigen Capture Enzyme-Linked Immunosorbent Assay Reveals High Levels of the Dengue Virus Protein NS1 in the Sera of Infected Patients , 2000, Journal of Clinical Microbiology.

[42]  P. Schlagenhauf,et al.  Malaria Chemoprophylaxis: Strategies for Risk Groups , 2008, Clinical Microbiology Reviews.

[43]  K. Leder Travelers as a sentinel population: Use of sentinel networks to inform pretravel and posttravel evaluation , 2008, Current infectious disease reports.

[44]  R. Barrera,et al.  Preparedness and response for Chikungunya virus introduction in the Americas , 2011 .

[45]  D. Fry Sepsis Syndrome , 2000, The American surgeon.

[46]  G. Crane Dengue haemorrhagic fever: diagnosis, treatment, prevention and control , 1999 .

[47]  Frank Kunst,et al.  Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak , 2006, PLoS medicine.

[48]  A. Barrett,et al.  Arthropod-Borne Flaviviruses , 2009 .

[49]  H. Mohammed,et al.  Travel-associated Dengue surveillance - United States, 2006-2008. , 2010, MMWR. Morbidity and mortality weekly report.

[50]  S. Yoksan,et al.  The Use of Dengue Nonstructural Protein 1 Antigen for the Early Diagnosis During the Febrile Stage in Patients With Dengue Infection , 2008, The Pediatric infectious disease journal.

[51]  D. Richman,et al.  Clinical Virology, 3rd Edition , 2010 .

[52]  Albert D. M. E. Osterhaus,et al.  Detection of Immune-Complex-Dissociated Nonstructural-1 Antigen in Patients with Acute Dengue Virus Infections , 2003, Journal of Clinical Microbiology.

[53]  K. Ezzedine,et al.  Post-Epidemic Chikungunya Disease on Reunion Island: Course of Rheumatic Manifestations and Associated Factors over a 15-Month Period , 2009, PLoS neglected tropical diseases.

[54]  M. Cetron,et al.  Spectrum of disease and relation to place of exposure among ill returned travelers. , 2006, The New England journal of medicine.

[55]  Weltgesundheitsorganisation World malaria report , 2005 .

[56]  K. Shah,et al.  VIROLOGICAL INVESTIGATION OF THE EPIDEMIC OF HAEMORRHAGIC FEVER IN CALCUTTA: ISOLATION OF THREE STRAINS OF CHIKUNGUNYA VIRUS. , 1964, The Indian journal of medical research.

[57]  C. Lahariya,et al.  Emergence of chikungunya virus in Indian subcontinent after 32 years: A review. , 2006, Journal of vector borne diseases.

[58]  A. Siqueira,et al.  Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature , 2012, Malaria Journal.

[59]  S. Higgs,et al.  A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential , 2007, PLoS pathogens.

[60]  David G Lalloo,et al.  UK malaria treatment guidelines. , 2007, The Journal of infection.

[61]  Ramanan Laxminarayan,et al.  Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. , 2002, The Lancet. Infectious diseases.

[62]  K. Nicholson,et al.  Don’t Forget Dengue! Clinical Features of Dengue Fever in Returning Travellers , 1998, Journal of the Royal College of Physicians of London.

[63]  B. Autran,et al.  Persistent Chronic Inflammation and Infection by Chikungunya Arthritogenic Alphavirus in Spite of a Robust Host Immune Response , 2010, The Journal of Immunology.

[64]  Alain Michault,et al.  Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[65]  K. Kain,et al.  Imported malaria: prospective analysis of problems in diagnosis and management. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[66]  A. Das,et al.  Plasmodium vivax Malaria , 2005, Emerging infectious diseases.

[67]  S. Hongsiriwon,et al.  Dengue hemorrhagic fever in infants. , 2002, The Southeast Asian journal of tropical medicine and public health.

[68]  C. Reed Travel recommendations for older adults. , 2007, Clinics in geriatric medicine.

[69]  John E. Bennett,et al.  Principles and practice of infectious diseases. Vols 1 and 2. , 1979 .

[70]  M C ROBINSON,et al.  An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. I. Clinical features. , 1955, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[71]  I. Schuffenecker,et al.  Transmission verticale materno-fœtale du virus chikungunya , 2006 .

[72]  B. Genton,et al.  A review of malaria vaccine clinical projects based on the WHO rainbow table , 2012, Malaria Journal.

[73]  M. Cetron,et al.  Delayed onset of malaria--implications for chemoprophylaxis in travelers. , 2003, The New England journal of medicine.

[74]  R. Rakel,et al.  Conn's current therapy , 2006 .

[75]  W. Lumsden An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952-53. II. General description and epidemiology. , 1955, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[76]  Outbreak and spread of chikungunya. , 2007, Releve epidemiologique hebdomadaire.

[77]  R. Romi,et al.  Infection with chikungunya virus in Italy: an outbreak in a temperate region , 2007, The Lancet.

[78]  S. Schilling,et al.  Laboratory diagnosis of primary and secondary dengue infection. , 2004, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[79]  C. Wattal,et al.  Dengue NS1 antigen detection: a useful tool in early diagnosis of dengue virus infection. , 2010, Indian journal of medical microbiology.

[80]  Wilbur G Downs,et al.  Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control: by the World Health Organization vii + 58 pages, illustrated, World Health Organization, 1211 Geneva 27, Switzerland. 1986. $7.80 , 1987 .

[81]  D. Nacapunchai,et al.  In vitro effect of artesunate against Acanthamoeba spp. , 2002, The Southeast Asian journal of tropical medicine and public health.

[82]  D. Weiner,et al.  Chikungunya: A Potentially Emerging Epidemic? , 2010, PLoS neglected tropical diseases.

[83]  E. Hunsperger,et al.  Utility of a Commercial Nonstructural Protein 1 Antigen Capture Kit as a Dengue Virus Diagnostic Tool , 2010, Clinical and Vaccine Immunology.

[84]  J. Rosenblatt,et al.  Diagnostic performance of rapid diagnostic tests versus blood smears for malaria in US clinical practice. , 2009, Clinical Infectious Diseases.

[85]  P. Jambulingam,et al.  A226V mutation in virus during the 2007 chikungunya outbreak in Kerala, India. , 2008, The Journal of general virology.

[86]  Yelena Yesha,et al.  Dengue fever and dengue haemorrhagic fever. , 2006, The Nursing journal of India.

[87]  J. Chretien,et al.  Chikungunya in Europe: what's next? , 2007, The Lancet.

[88]  N. Mühlberger,et al.  Dengue - the underestimated risk in travellers. , 2003 .

[89]  Madison,et al.  Malaria surveillance--United States, 2010. , 2012, Morbidity and mortality weekly report. Surveillance summaries.

[90]  V. Batra,et al.  Improved Detection of Dengue Virus Serotypes from Serum Samples - Evaluation of Single-Tube Multiplex RT-PCR with Cell Culture , 2006 .

[91]  M. Guzmán,et al.  Clinical and serologic study of Cuban children with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). , 1987, Bulletin of the Pan American Health Organization.

[92]  M. Perkins,et al.  A Large Proportion of P. falciparum Isolates in the Amazon Region of Peru Lack pfhrp2 and pfhrp3: Implications for Malaria Rapid Diagnostic Tests , 2010, PloS one.

[93]  E. Jong The Travel and Tropical Medicine Manual , 2002 .

[94]  O. Thekisoe,et al.  Comparative diagnosis of malaria infections by microscopy, nested PCR, and LAMP in northern Thailand. , 2010, The American journal of tropical medicine and hygiene.

[95]  A. Nisalak,et al.  Early clinical and laboratory indicators of acute dengue illness. , 1997, The Journal of infectious diseases.

[96]  H. Reyburn,et al.  The effect of chemoprophylaxis on the timing of onset of falciparum malaria , 1998, Tropical medicine & international health : TM & IH.

[97]  V. Arankalle,et al.  Evolutionary rates and timescale comparison of Chikungunya viruses inferred from the whole genome/E1 gene with special reference to the 2005-07 outbreak in the Indian subcontinent. , 2009, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.