Iterative improvement of lineshape estimation

Magnetic Resonance Spectroscopy (MRS) is an effective diagnostic technique for monitoring metabolic and biochemical changes within an organism or sample. Static and dynamic inhomogeneity of the magnetic field applied to the patient distorts the function that governs the natural damping of the MRS signals. This damping function can be expressed in the frequency domain as a Lorentzian, Gaussian, or Voigt function; however, using these approximations, estimation of the desired in vivo metabolite concentrations may be biased.