Chemical exchange saturation transfer (CEST) imaging with fast variably‐accelerated sensitivity encoding (vSENSE)

The widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered by relatively long scan times due to its requirement that multiple saturation‐offset image frames be acquired. Here, a novel variably‐accelerated sensitivity encoding (vSENSE) method is proposed that provides faster CEST acquisition than conventional SENSE.

[1]  P. Bottomley.  Spatial Localization in NMR Spectroscopy in Vivo , 1987, Annals of the New York Academy of Sciences.

[2]  Michael Schär,et al.  Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. , 2012, Journal of magnetic resonance.

[3]  Dong-Hoon Lee,et al.  Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques , 2017, Magnetic resonance in medicine.

[4]  Jinyuan Zhou,et al.  Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging , 2008, Magnetic resonance in medicine.

[5]  Dana H. Brooks,et al.  A tour of accelerated parallel MR imaging from a linear systems perspective , 2005 .

[6]  Jinyuan Zhou,et al.  Three‐dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement , 2013, Journal of magnetic resonance imaging : JMRI.

[7]  Peter Bachert,et al.  Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. , 2011, Journal of magnetic resonance.

[8]  Leslie Ying,et al.  Joint image reconstruction and sensitivity estimation in SENSE (JSENSE) , 2007, Magnetic resonance in medicine.

[9]  Jinyuan Zhou,et al.  Chemical exchange saturation transfer imaging and spectroscopy , 2006 .

[10]  R E Lenkinski,et al.  Keyhole chemical exchange saturation transfer , 2012, Magnetic resonance in medicine.

[11]  Hye-Young Heo,et al.  Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semi‐solid magnetization transfer reference (EMR) signals: Application to a rat glioma model at 4.7 tesla , 2016, Magnetic resonance in medicine.

[12]  Ravinder Reddy,et al.  CEST signal at 2 ppm (CEST@2ppm) from Z‐spectral fitting correlates with creatine distribution in brain tumor , 2014, NMR in biomedicine.

[13]  Jiadi Xu,et al.  Variable delay multi‐pulse train for fast chemical exchange saturation transfer and relayed‐nuclear overhauser enhancement MRI , 2014, Magnetic resonance in medicine.

[14]  Hye-Young Heo,et al.  Molecular MRI differentiation between primary central nervous system lymphomas and high-grade gliomas using endogenous protein-based amide proton transfer MR imaging at 3 Tesla , 2015, European Radiology.

[15]  Paul A Bottomley,et al.  Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. , 2013, Journal of magnetic resonance.

[16]  Dong-Hoon Lee,et al.  Highly accelerated chemical exchange saturation transfer (CEST) measurements with linear algebraic modeling , 2016, Magnetic resonance in medicine.

[17]  A Dean Sherry,et al.  Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. , 2008, Annual review of biomedical engineering.

[18]  Jinyuan Zhou,et al.  Amide proton transfer (APT) contrast for imaging of brain tumors , 2003, Magnetic resonance in medicine.

[19]  Koji Yamashita,et al.  Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades. , 2014, Neuro-oncology.

[20]  M A Griswold,et al.  CEST‐FISP: A novel technique for rapid chemical exchange saturation transfer MRI at 7 T , 2011, Magnetic resonance in medicine.

[21]  D B Plewes,et al.  Limitations of the keyhole technique for quantitative dynamic contrast‐enhanced breast MRI , 1997, Journal of magnetic resonance imaging : JMRI.

[22]  Jinyuan Zhou,et al.  In vivo three‐dimensional whole‐brain pulsed steady‐state chemical exchange saturation transfer at 7 T , 2012, Magnetic resonance in medicine.

[23]  Christopher Witte,et al.  Slice-selective gradient-encoded CEST spectroscopy for monitoring dynamic parameters and high-throughput sample characterization. , 2013, Journal of magnetic resonance.

[24]  Mark F. Lythgoe,et al.  In vivo imaging of glucose uptake and metabolism in tumors , 2012, Nature Medicine.

[25]  Thomas E Yankeelov,et al.  Amide proton transfer imaging of the breast at 3 T: Establishing reproducibility and possible feasibility assessing chemotherapy response , 2013, Magnetic resonance in medicine.

[26]  Hugues Benoit-Cattin,et al.  Intensity non-uniformity correction in MRI: Existing methods and their validation , 2006, Medical Image Anal..

[27]  Alexej Jerschow,et al.  Ultrafast scanning of exchangeable sites by NMR spectroscopy. , 2013, Angewandte Chemie.

[28]  David C Alsop,et al.  Amide proton transfer imaging with improved robustness to magnetic field inhomogeneity and magnetization transfer asymmetry using saturation with frequency alternating RF irradiation , 2011, Magnetic resonance in medicine.

[29]  N J Pelc,et al.  Unaliasing by Fourier‐encoding the overlaps using the temporal dimension (UNFOLD), applied to cardiac imaging and fMRI , 1999, Magnetic resonance in medicine.

[30]  J. Bulte,et al.  In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes , 2012, Magnetic resonance in medicine.

[31]  Kimberly L Desmond,et al.  Mapping of amide, amine, and aliphatic peaks in the CEST spectra of murine xenografts at 7 T , 2014, Magnetic resonance in medicine.

[32]  Yoshinori Kato,et al.  Natural D‐glucose as a biodegradable MRI contrast agent for detecting cancer , 2012, Magnetic resonance in medicine.

[33]  Leif Østergaard,et al.  Assessment of ischemic penumbra in patients with hyperacute stroke using amide proton transfer (APT) chemical exchange saturation transfer (CEST) MRI , 2014, NMR in biomedicine.

[34]  Miha Fuderer,et al.  SENSE with improved tolerance to inaccuracies in coil sensitivity maps , 2013, Magnetic resonance in medicine.

[35]  Yi Zhang,et al.  Simultaneous detection and separation of hyperacute intracerebral hemorrhage and cerebral ischemia using amide proton transfer MRI , 2015, Magnetic resonance in medicine.

[36]  P. Boesiger,et al.  SENSE: Sensitivity encoding for fast MRI , 1999, Magnetic resonance in medicine.

[37]  R. Lenkinski,et al.  UCEPR: Ultrafast localized CEST‐spectroscopy with PRESS in phantoms and in vivo , 2016, Magnetic resonance in medicine.

[38]  D. Donoho,et al.  Sparse MRI: The application of compressed sensing for rapid MR imaging , 2007, Magnetic resonance in medicine.

[39]  Kai Zhang,et al.  Selecting the reference image for registration of CEST series , 2016, Journal of magnetic resonance imaging : JMRI.

[40]  Nirbhay N. Yadav,et al.  Chemical exchange saturation transfer (CEST): What is in a name and what isn't? , 2011, Magnetic resonance in medicine.

[41]  Joseph V. Hajnal,et al.  High Signal Regions in Normal White Matter Shown by Heavily T2‐Weighted CSF Nulled IR Sequences , 1992, Journal of computer assisted tomography.

[42]  Wilson Fong.  Handbook of MRI Pulse Sequences , 2005 .

[43]  W. Cleveland.  Robust Locally Weighted Regression and Smoothing Scatterplots , 1979 .

[44]  Jinyuan Zhou,et al.  Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI , 2003, Nature Medicine.

[45]  Jinyuan Zhou,et al.  Amide proton transfer MR imaging of prostate cancer: A preliminary study , 2011, Journal of magnetic resonance imaging : JMRI.

[46]  J. Mugler,et al.  Three‐dimensional magnetization‐prepared rapid gradient‐echo imaging (3D MP RAGE) , 1990, Magnetic resonance in medicine.

[47]  Bennett A Landman,et al.  Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments , 2009, Magnetic resonance in medicine.

[48]  R S Balaban,et al.  A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). , 2000, Journal of magnetic resonance.

[49]  Ravinder Reddy,et al.  A technique for in vivo mapping of myocardial creatine kinase metabolism , 2014, Nature Medicine.

[50]  P. Roemer,et al.  The NMR phased array , 1990, Magnetic resonance in medicine.

[51]  Hye-Young Heo,et al.  Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer reference (EMR) signals: II. Comparison of three EMR models and application to human brain glioma at 3 Tesla , 2016, Magnetic resonance in medicine.

[52]  P. Boesiger,et al.  Advances in sensitivity encoding with arbitrary k‐space trajectories , 2001, Magnetic resonance in medicine.

[53]  J. J. van Vaals,et al.  “Keyhole” method for accelerating imaging of contrast agent uptake , 1993, Journal of magnetic resonance imaging : JMRI.

[54]  Peter Jezzard,et al.  Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging , 2014, Brain : a journal of neurology.

[55]  Yi Zhang,et al.  Accelerated Spatially Encoded Spectroscopy of Arbitrarily Shaped Compartments Using Prior Knowledge and Linear Algebraic Modeling , 2015 .

[56]  Hye-Young Heo,et al.  Applying amide proton transfer‐weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas , 2016, Journal of magnetic resonance imaging : JMRI.

[57]  Robin M Heidemann,et al.  Generalized autocalibrating partially parallel acquisitions (GRAPPA) , 2002, Magnetic resonance in medicine.

[58]  Vaibhav A. Janve,et al.  Multi‐angle ratiometric approach to measure chemical exchange in amide proton transfer imaging , 2012, Magnetic resonance in medicine.

[59]  Klaas Paul Pruessmann,et al.  Realistic Analytical Phantoms for Parallel Magnetic Resonance Imaging , 2012, IEEE Transactions on Medical Imaging.

[60]  John A. Detre,et al.  Magnetic Resonance Imaging of Glutamate , 2011, Nature Medicine.

[61]  Jinyuan Zhou,et al.  Fast 3D chemical exchange saturation transfer (CEST) imaging of the human brain , 2010, Magnetic resonance in medicine.

[62]  K P Pruessmann,et al.  Sensitivity‐encoded spectroscopic imaging , 2001, Magnetic resonance in medicine.

[63]  Jia-Hong Gao,et al.  Improved SENSE imaging using accurate coil sensitivity maps generated by a global magnitude‐phase fitting method , 2015, Magnetic resonance in medicine.