Epimuscular myofascial force transmission between antagonistic and synergistic muscles can explain movement limitation in spastic paresis.

Details and concepts of intramuscular, extramuscular and intermuscular myofascial force transmission are reviewed. Some new experimental data are added regarding myofascial force transmission between antagonistic muscles across the interosseal membrane of the lower hind limb of the rat. Combined with other result presented in this issue, it can be concluded that myofascial force transmission occurs between all muscles within a limb segment. This means that force generated within sarcomeres of an antagonistic muscle may be exerted at the tendon of target muscle or its synergists. Some, in vivo, but initial indications for intersegmental myofascial force transmission are discussed. The concept of myofascial force transmission as an additional load on the muscle proved to be fruitful in the analysis of its muscular effects. In spastic paresis and for healthy muscles distal myofascial loads are often encountered, but cannot fully explain the movement limitations in spastic paresis. Therefore, the concept of simultaneous and opposing myofascial loads is analyzed and used to formulate a hypothesis for explaining the movement limitation: Myofascially transmitted antagonistic force is borne by the spastic muscle, but subsequently transmitted again to distal tendons of synergistic muscles.

[1]  W. Akeson,et al.  Spasticity and contracture. Physiologic aspects of formation. , 1988, Clinical orthopaedics and related research.

[2]  P. Huijing,et al.  Differential effects of muscle fibre length and insulin on muscle-specific mRNA content in isolated mature muscle fibres during long-term culture , 2006, Cell and Tissue Research.

[3]  J. Marini,et al.  Structural organization of the perimysium in bovine skeletal muscle: Junctional plates and associated intracellular subdomains. , 2006, Journal of structural biology.

[4]  P. Huijing,et al.  Biomechanical effects of dissecting flexor carpi ulnaris. , 2003, The Journal of bone and joint surgery. British volume.

[5]  C. Snijders,et al.  The Posterior Layer of the Thoracolumbar Fascia|Its Function in Load Transfer From Spine to Legs , 1995, Spine.

[6]  Immobilization and muscle atrophy. , 1976, Transactions of the American Neurological Association.

[7]  M. Smeulders,et al.  Myofascial force transmission and tendon transfer for patients suffering from spastic paresis: a review and some new observations. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[8]  D. Hukins.  Connective Tissue Matrix , 1984 .

[9]  Adam P Shortland,et al.  The morphology of the medial gastrocnemius in typically developing children and children with spastic hemiplegic cerebral palsy. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[10]  P A Huijing,et al.  Effects of short length immobilization of medial gastrocnemius muscle of growing young adult rats. , 1992, European journal of morphology.

[11]  Peter A Huijing,et al.  Effects of inter- and extramuscular myofascial force transmission on adjacent synergistic muscles: assessment by experiments and finite-element modeling. , 2003, Journal of biomechanics.

[12]  P. Huijing,et al.  Myofascial force transmission also occurs between antagonistic muscles located within opposite compartments of the rat lower hind limb. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[13]  P. Huijing,et al.  IMPLICATIONS OF MUSCLE RELATIVE POSITION AS A CO-DETERMINANT OF ISOMETRIC MUSCLE FORCE: A REVIEW AND SOME EXPERIMENTAL RESULTS , 2003 .

[14]  T. Nishimura,et al.  Structural changes in the intramuscular connective tissue during development of bovine semitendinosus muscle. , 1996, Tissue & cell.

[15]  T. Fukunaga,et al.  Changes in muscle size, architecture, and neural activation after 20 days of bed rest with and without resistance exercise , 2001, European Journal of Applied Physiology.

[16]  Yasuo Kawakami,et al.  Elastic properties of muscle-tendon complex in long-distance runners , 2000, European Journal of Applied Physiology.

[17]  P Huijing,et al.  Muscular force transmission: a unified, dual or multiple system? A review and some explorative experimental results. , 1999, Archives of physiology and biochemistry.

[18]  C. Tardieu,et al.  Muscle hypoextensibility in children with cerebral palsy: II. Therapeutic implications. , 1982, Archives of physical medicine and rehabilitation.

[19]  P. Huijing,et al.  Muscle length-force characteristics in relation to muscle architecture: a bilateral study of gastrocnemius medialis muscles of unilaterally immobilized rats , 2004, European Journal of Applied Physiology and Occupational Physiology.

[20]  P A Huijing,et al.  Muscle as a collagen fiber reinforced composite: a review of force transmission in muscle and whole limb. , 1999, Journal of biomechanics.

[21]  T. Nishimura,et al.  Developmental expression of extracellular matrix components in intramuscular connective tissue of bovine semitendinosus muscle , 1997, Histochemistry and Cell Biology.

[22]  M Gough,et al.  Architecture of the medial gastrocnemius in children with spastic diplegia , 2001, Developmental medicine and child neurology.

[23]  G. Goldspink,et al.  Changes in sarcomere length and physiological properties in immobilized muscle. , 1978, Journal of anatomy.

[24]  D. Ingber.  Mechanosensation through integrins: Cells act locally but think globally , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  T. Nishimura,et al.  Changes in mechanical strength of intramuscular connective tissue during postmortem aging of beef. , 1998, Journal of animal science.

[26]  C. Maganaris,et al.  In vivo measurements of the triceps surae complex architecture in man: implications for muscle function , 1998, The Journal of physiology.

[27]  P. Huijing,et al.  Effects of strain on contractile force and number of sarcomeres in series of Xenopus laevis single muscle fibres during long-term culture , 2004, Journal of Muscle Research & Cell Motility.

[28]  B. Palmer,et al.  Myosin light chain phosphorylation and tension potentiation in mouse skeletal muscle. , 1989, The American journal of physiology.

[29]  Peter A Huijing,et al.  Muscle force is determined also by muscle relative position: isolated effects. , 2004, Journal of biomechanics.

[30]  P.A.J.B.M. Huijing.  Muscle as a collagen fiber reinforced composite material: Force transmission in muscle and whole limbs , 1997 .

[31]  S. Schäfer.  Oscillations in the discharge frequency of cat primary muscle spindle afferents during the dynamic phase of a ramp-and-hold stretch , 1995, Brain Research.

[32]  J. Stull,et al.  Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[33]  R. Young,et al.  Pathophysiology of spastic paresis , 1990 .

[34]  C Tardieu,et al.  Muscle hypoextensibility in children with cerebral palsy: I. Clinical and experimental observations. , 1982, Archives of physical medicine and rehabilitation.

[35]  D. Ingber.  Tensegrity: the architectural basis of cellular mechanotransduction. , 1997, Annual review of physiology.

[36]  P. Huijing.  Muscular Force Transmission Necessitates a Multilevel Integrative Approach to the Analysis of Function of Skeletal Muscle , 2003, Exercise and sport sciences reviews.

[37]  P. Huijing,et al.  Intermuscular Interaction between Synergists in Rat Originates from both Intermuscular and Extramuscular Myofascial Force Transmission , 2006, Cells Tissues Organs.

[38]  Peter A Huijing,et al.  Extramuscular myofascial force transmission also occurs between synergistic muscles and antagonistic muscles. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[39]  T Fukunaga,et al.  Influence of elastic properties of tendon structures on jump performance in humans. , 1999, Journal of applied physiology.

[40]  J. P. Paul,et al.  In vivo human tendon mechanical properties , 1999, The Journal of physiology.

[41]  T. Nishimura,et al.  Structural changes in intramuscular connective tissue during the fattening of Japanese black cattle: effect of marbling on beef tenderization. , 1999, Journal of animal science.

[42]  P. Huijing,et al.  Growth and immobilization effects on sarcomeres: a comparison between gastrocnemius and soleus muscles of the adult rat , 2004, European Journal of Applied Physiology and Occupational Physiology.

[43]  P. Huijing,et al.  Substantial effects of epimuscular myofascial force transmission on muscular mechanics have major implications on spastic muscle and remedial surgery. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[44]  Jean-Michel Gracies,et al.  Pathophysiology of spastic paresis. I: Paresis and soft tissue changes , 2005, Muscle & nerve.

[45]  R. Ramsey,et al.  Sarcolemma: Transmitter of Active Tension in Frog Skeletal Muscle , 1965, Science.

[46]  S. Glagov,et al.  CORRELATION OF MECHANICAL BEHAVIOR AND MMP-1 PRESENCE IN HUMAN ATHEROSCLEROTIC PLAQUE , 2002 .

[47]  P. Purslow,et al.  Structure and Function of Intramuscular Connective Tissue , 1990 .

[48]  Peter A Huijing,et al.  Myofascial force transmission: muscle relative position and length determine agonist and synergist muscle force. , 2003, Journal of applied physiology.

[49]  P. Huijing,et al.  Myofascial force transmission between antagonistic rat lower limb muscles: effects of single muscle or muscle group lengthening. , 2007, Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology.

[50]  H. Appell.  Skeletal Muscle Atrophy During Immobilization , 1986, International journal of sports medicine.

[51]  G. Goldspink,et al.  Connective tissue changes in immobilised muscle. , 1984, Journal of anatomy.

[52]  B. Koopman,et al.  Extramuscular Myofascial Force Transmission: Experiments and Finite Element Modeling , 2003, Archives of physiology and biochemistry.

[53]  K Takahashi,et al.  Arrangement and identification of proteoglycans in basement membrane and intramuscular connective tissue of bovine semitendinosus muscle. , 1996, Acta anatomica.

[54]  Peter P. Purslow,et al.  The morphology and mechanical properties of endomysium in series-fibred muscles: variations with muscle length , 1994, Journal of Muscle Research & Cell Motility.

[55]  T. Nishimura,et al.  Relationship between degradation of proteoglycans and weakening of the intramuscular connective tissue during post-mortem ageing of beef. , 1996, Meat science.

[56]  M. Järvinen,et al.  Organization and distribution of intramuscular connective tissue in normal and immobilized skeletal muscles , 2004, Journal of Muscle Research & Cell Motility.

[57]  J. Stull,et al.  Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle. , 1982, The American journal of physiology.

[58]  J. Gracies,et al.  Pathophysiology of spastic paresis. II: Emergence of muscle overactivity , 2005, Muscle & nerve.

[59]  P. Neilson,et al.  REDUCTION OF SPASTICITY IN cérébral PALSY USING FEEDBACK OF THE TONIC STRE1CH REFLEX; A CONTROLLED STUDY , 1994, Developmental Medicine & Child Neurology.

[60]  R L Lieber,et al.  Muscle fiber length and moment arm coordination during dorsi- and plantarflexion in the mouse hindlimb. , 1997, Acta anatomica.

[61]  M. Bobbert,et al.  Length and moment arm of human leg muscles as a function of knee and hip-joint angles , 2004, European Journal of Applied Physiology and Occupational Physiology.

[62]  Peter A Huijing,et al.  Mechanisms causing effects of muscle position on proximo-distal muscle force differences in extra-muscular myofascial force transmission. , 2006, Medical engineering & physics.

[63]  P. Huijing.  INTRA-, EXTRA- AND INTERMUSCULAR MYOFASCIAL FORCE TRANSMISION OF SYNERGISTS AND ANTAGONISTS: EFFECTS OF MUSCLE LENGTH AS WELL AS RELATIVE POSITION , 2002 .

[64]  Kevin C McGill,et al.  Neuromuscular activation and motor-unit firing characteristics in cerebral palsy. , 2005, Developmental medicine and child neurology.

[65]  J. Stull,et al.  Myosin light chain phosphorylation and isometric twitch potentiation in intact human muscle , 1985, Pflügers Archiv.

[66]  Overstretching of sarcomeres may not cause cerebral palsy muscle contracture , 2004, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[67]  T. Nishimura,et al.  Ultrastructure of the intramuscular connective tissue in bovine skeletal muscle. A demonstration using the cell-maceration/scanning electron microscope method. , 1994, Acta anatomica.

[68]  B Roszek,et al.  Decreasing stimulation frequency-dependent length-force characteristics of rat muscle. , 1994, Journal of applied physiology.

[69]  D. Goldspink,et al.  Muscle growth in response to mechanical stimuli. , 1995, The American journal of physiology.

[70]  D. Ingber.  Tensegrity II. How structural networks influence cellular information processing networks , 2003, Journal of Cell Science.

[71]  S. Street,et al.  Lateral transmission of tension in frog myofibers: A myofibrillar network and transverse cytoskeletal connections are possible transmitters , 1983, Journal of cellular physiology.

[72]  P. Huijing,et al.  Adaptation of muscle size and myofascial force transmission: a review and some new experimental results , 2005, Scandinavian journal of medicine & science in sports.

[73]  J. Trotter,et al.  Functional morphology of the endomysium in series fibered muscles , 1992, Journal of morphology.

[74]  P A Huijing,et al.  Extramuscular myofascial force transmission within the rat anterior tibial compartment: proximo-distal differences in muscle force. , 2001, Acta physiologica Scandinavica.

[75]  F. Booth.  Time course of muscular atrophy during immobilization of hindlimbs in rats. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[76]  P A Huijing,et al.  Non-myotendinous force transmission in rat extensor digitorum longus muscle. , 1998, The Journal of experimental biology.

[77]  C. Maganaris,et al.  Force-length characteristics of in vivo human skeletal muscle. , 2001, Acta physiologica Scandinavica.