The aerial parts of Cluytia richardiana yielded five new modified 6,7-secolabdane diterpene derivatives, saudinolide (4), dihydrosaudinolide (5), 5β-hydroxyrichardianidin 1(6), and 5β-hydroxyrichardianidin 2 (7), and the 6,7-seco-6,11-cyclo-20-norlabdane cluytene F (8). The structural assignments of the diterpenoids were based on their spectral data, including 2D NMR experiments, and chemical derivatization. X-ray crystallographic analyses provided unambiguous characterization of the structures and relative stereochemistries of 4, 6, 7, and 1-O-acetylcluytene F (10).