Assessment of myocardial repolarisation parameters in patients with familial Mediterranean fever

Summary Background: Familial Mediterranean fever (FMF) is a chronic, recurrent auto-inflammatory disease characterised by self-terminating attacks of fever and sterile polyserositis. The main cause of death in auto-inflammatory diseasesis cardiovascular events. Additionally, auto-inflammatory diseases have potential effects on the myocardial repolarisation parameters, including the T-wave peak-to-end (Tp-Te) interval, cTp-Te interval (corrected Tp-Te) and the cTp-Te/ QT ratio. The aim of this study was to analyse the efficacy of myocardial repolarisation alterations in anticipation of cardiovascular risks in patients with FMF. Methods: This study included 66 patients with FMF and 58 healthy control subjects. Tp-Te and cTp-Te intervals and the cTp-Te/QT ratio were measured from the 12-lead electrocardiogram. Results: In electrocardiographic parameters, analysis of QT, QT dispersion, corrected QT (QTc) and QTc dispersion were similar between the groups. The Tp-Te and cTp-Te intervals and Tp-Te/QT and cTp-Te/QT ratios were significantly prolonged in FMF patients. Multivariate linear regression analyses indicated that erythrocyte sedimentation rate was an independent predictor of a prolonged cTp-Te interval. Conclusions: Our study revealed that when compared with control subjects, Tp-Te and cTp-Te intervals and cTp-Te/QT ratio were increased in FMF patients.

[1]  S. Ozen,et al.  Assessment of autonomic functions in children with familial Mediterranean fever by using heart rate variability measurements , 2017, International journal of rheumatic diseases.

[2]  A. Örnek,et al.  P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany , 2014, International journal of medical sciences.

[3]  M. Eren,et al.  Can the T-peak to T-end interval be a predictor of mortality in patients with ST-elevation myocardial infarction? , 2014, Coronary artery disease.

[4]  A. Avci,et al.  Assessment of Inhomogeneities of Repolarization in Patients with Systemic Lupus Erythematosus , 2014, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[5]  J. Tisdale,et al.  QT interval prolongation and the risk of torsades de pointes: essentials for clinicians , 2013, Current medical research and opinion.

[6]  K. Deveci,et al.  Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever? , 2013, BioMed research international.

[7]  A. Erdem,et al.  Polymorphic ventricular tachycardia (Torsades de pointes) due to licorice root tea. , 2013, Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.

[8]  A. Oto,et al.  Evaluation of various cardiac autonomic indices in patients with familial Mediterranean fever on colchicine treatment , 2012, Autonomic Neuroscience.

[9]  H. Lachmann.  Clinical Immunology Review Series: An approach to the patient with a periodic fever syndrome , 2011, Clinical and experimental immunology.

[10]  S. Akdağ,et al.  The effects of perindopril on QT duration and dispersion in patients with coronary slow flow , 2011, Heart and Vessels.

[11]  Katerina Hnatkova,et al.  Assessment of repolarization heterogeneity for prediction of mortality in cardiovascular disease: peak to the end of the T wave interval and nondipolar repolarization components. , 2011, Journal of electrocardiology.

[12]  I. Ben-Zvi,et al.  Chronic inflammation in FMF: markers, risk factors, outcomes and therapy , 2011, Nature Reviews Rheumatology.

[13]  A. Sokmen,et al.  QT dispersion and transmural dispersion of repolarization in patients with familial Mediterranean fever , 2009, Modern rheumatology.

[14]  G. Yan,et al.  T(p-e)/QT ratio as an index of arrhythmogenesis. , 2008, Journal of electrocardiology.

[15]  G. van Herpen,et al.  The meaning of the Tp-Te interval and its diagnostic value. , 2008, Journal of electrocardiology.

[16]  H. Gullu,et al.  Impaired coronary microvascular function in familial Mediterranean fever. , 2007, Atherosclerosis.

[17]  Li Zhang,et al.  Does Tpeak-Tend provide an index of transmural dispersion of repolarization? , 2007, Heart rhythm.

[18]  A. Oto,et al.  Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF. , 2006, Journal of the American College of Cardiology.

[19]  P. Seferovic,et al.  Cardiac arrhythmias and conduction disturbances in autoimmune rheumatic diseases. , 2006, Rheumatology.

[20]  D. Booth,et al.  Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. , 2006, Rheumatology.

[21]  Charles Antzelevitch,et al.  Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. , 2006, Journal of the American College of Cardiology.

[22]  Richard B Devereux,et al.  Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardio , 2005, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[23]  J. Lekakis,et al.  Aortic elastic properties and left ventricular diastolic function in patients with Adamantiades-Behcet's disease. , 2004, Journal of the American College of Cardiology.

[24]  H. Mabuchi,et al.  T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity. , 2003, Clinical science.

[25]  D. Yeshurun,et al.  Cardiovascular autonomic dysfunction in familial Mediterranean fever. , 2002, The Journal of rheumatology.

[26]  G L Freeman,et al.  High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors. , 2001, Arthritis and rheumatism.

[27]  K. Kostner,et al.  Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. , 2000, The American journal of cardiology.

[28]  T. Miller,et al.  Cardiac involvement in systemic lupus erythematosus. , 1999, Mayo Clinic proceedings.

[29]  D. Zemer,et al.  Criteria for the diagnosis of familial Mediterranean fever. , 1997, Arthritis and rheumatism.

[30]  H. Bazett,et al.  AN ANALYSIS OF THE TIME‐RELATIONS OF ELECTROCARDIOGRAMS. , 1997 .

[31]  A Nava,et al.  Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. , 1993, The American journal of cardiology.

[32]  R. Ross.  The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[33]  R. Bahler,et al.  Alterations in cardiac diastolic function in patients with ankylosing spondylitis. , 1992, International journal of cardiology.

[34]  J. Mccomb,et al.  QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. , 1990, British heart journal.

[35]  E. Sohar,et al.  Familial Mediterranean fever. , 1955, Klinische Padiatrie.

[36]  M. Çetin,et al.  Evaluation of Tp-e interval and Tp-e/QT ratio in patients with rheumatoid arthritis. , 2014, Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.

[37]  A. Oto,et al.  Heart-rate recovery index is impaired in Behçet's disease. , 2009, Texas Heart Institute journal.

[38]  C Antzelevitch,et al.  Cellular basis for QT dispersion. , 1998, Journal of electrocardiology.

[39]  E. Sohar,et al.  Ethnic distribution and amyloidosis in familial Mediterranean fever (FMF). , 1961, Pathologia et microbiologia.