Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: a meta-analysis of studies with the stop task.

The aim of this study was to investigate whether impaired response inhibition is uniquely related to AD/HD or whether deficits in response inhibition are also evident in other psychopathological disorders. Furthermore, the suggestion was examined that anxiety disorders are associated with abnormally high levels of response inhibition. This paper presents the results of a meta-analysis of eight studies in which response inhibition was assessed with the so-called stop task in five groups of children: children with attention deficit/hyperactivity disorder (AD/HD), children with conduct disorder (CD), children with AD/HD + CD, children with anxiety disorders, and control children. A total of 456 children participated in the 8 studies. All children were in the age range 6-12 years. Consistent and robust evidence was found for a response inhibition deficit in AD/HD. However, response inhibition deficits did not distinguish children with AD/HD from children with CD, nor from children with comorbid AD/HD + CD. Contrary to predictions, anxious children did not demonstrate enhanced levels of response inhibition.

[1]  J. C. Masters,et al.  Interrupting the Flow of Behavior: The Stability and Development of Children's Initiation and Maintenance of Compliant Response Inhibition. , 1978 .

[2]  W. F. Caul,et al.  Attention deficit disorder with hyperactivity: a specific hypothesis of reward dysfunction. , 1987, Journal of the American Academy of Child and Adolescent Psychiatry.

[3]  L. Siegel,et al.  Is the Continuous Performance Task a valuable research tool for use with children with Attention-Deficit-Hyperactivity Disorder? , 1993, Journal of child psychology and psychiatry, and allied disciplines.

[4]  T. Moffitt,et al.  Measuring impulsivity and examining its relationship to delinquency. , 1994, Journal of abnormal psychology.

[5]  T. Achenbach.  Integrative Guide for the 1991 CBCL/4-18, Ysr, and Trf Profiles , 1991 .

[6]  H. Quay.  The psychobiology of undersocialized aggressive conduct disorder: A theoretical perspective , 1993, Development and Psychopathology.

[7]  Gwenn W. Gröndal,et al.  Meta-analytic procedures for social research , 1993 .

[8]  R. Tannock,et al.  Deficient inhibitory control in attention deficit hyperactivity disorder , 1995, Journal of abnormal child psychology.

[9]  P. Leung,et al.  Clinic observations in the assessment of pervasiveness of childhood hyperactivity. , 1991, Journal of child psychology and psychiatry, and allied disciplines.

[10]  M. Solanto.  The effects of reinforcement and response-cost on a delayed response task in children with attention deficit hyperactivity disorder: a research note. , 1990, Journal of child psychology and psychiatry, and allied disciplines.

[11]  Maurits W van der Molen,et al.  Inhibition in boys with attention deficit hyperactivity disorder as indexed by heart rate change. , 1997, Developmental psychology.

[12]  T. Achenbach,et al.  Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. , 1987, Psychological bulletin.

[13]  P. Wender.  THE MINIMAL BRAIN DYSFUNCTION SYNDROME IN CHILDREN: I–THE SYNDROME AND ITS RELEVANCE FOE PSYCHIATRY II–A PSYCHOLOGICAL AND BIOCHEMICAL MODEL FOR THE SYNDROME , 1972, The Journal of nervous and mental disease.

[14]  J. Torgesen.  Issues in the assessment of executive function: An information-processing perspective. , 1994 .

[15]  J. Halperin,et al.  Attention, Response Inhibition, and Activity Level in Children: Developmental Neuropsychological Perspectives , 1994 .

[16]  L. Greenhill.  Ritalin: Theory and Patient Management , 1991 .

[17]  K. Pribram,et al.  Arousal, activation, and effort in the control of attention. , 1975, Psychological review.

[18]  P. Lachenbruch.  Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[19]  V. Douglas.  Chapter 9 – CAN SKINNERIAN THEORY EXPLAIN ATTENTION DEFICIT DISORDER? — A REPLY TO BARKLEY , 1989 .

[20]  E. Sonuga-Barke,et al.  Hyperactivity and delay aversion--II. The effect of self versus externally imposed stimulus presentation periods on memory. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[21]  J. Sergeant,et al.  Sustained attention and pervasive hyperactivity. , 1991, Journal of child psychology and psychiatry, and allied disciplines.

[22]  Gordon D. Logan,et al.  Dependence and independence in responding to double stimulation: A comparison of stop, change, and dual-task paradigms. , 1986 .

[23]  E. Sonuga-Barke,et al.  Hyperactivity and delay aversion--I. The effect of delay on choice. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[24]  Mardi J. Horowitz,et al.  The Psychology of Fear and Stress, 2nd ed , 1989 .

[25]  R. Loeber,et al.  Oppositional defiant and conduct disorders: issues to be resolved for DSM-IV. , 1992, Journal of the American Academy of Child and Adolescent Psychiatry.

[26]  T. Saxton,et al.  Hyperactivity and delay aversion. III: The effect on cognitive style of imposing delay after errors. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[27]  T. Achenbach.  Taxonomy and comorbidity of conduct problems: Evidence from empirically based approaches , 1993, Development and Psychopathology.

[28]  Jacob Cohen.  Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[29]  J. Kagan,et al.  Behavioral inhibition as a risk factor for anxiety disorders. , 1995 .

[30]  R Tannock,et al.  Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children , 1995, Journal of abnormal child psychology.

[31]  G. Logan.  On the ability to inhibit thought and action , 1984 .

[32]  R. Barkley,et al.  Frontal lobe functions in attention deficit disorder with and without hyperactivity: A review and research report , 1992, Journal of abnormal child psychology.

[33]  Benjamin B. Lahey,et al.  Issues of taxonomy and comorbidity in the development of conduct disorder , 1993, Development and Psychopathology.

[34]  H. Quay,et al.  Response perseveration and delayed responding in childhood behavior disorders. , 1991, Journal of child psychology and psychiatry, and allied disciplines.

[35]  V. Douglas,et al.  Cognitive styles in hyperactive children and the effect of methylphenidate. , 1971, Journal of child psychology and psychiatry, and allied disciplines.

[36]  G. Hynd,et al.  Frontal lobe functioning in conduct disordered juveniles: preliminary findings. , 1990, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[37]  P. Jensen,et al.  Comorbidity of disorders in children and adolescents: Developmental perspectives. , 1995 .

[38]  R. Mcgee,et al.  Attention deficit disorder and age of onset of problem behaviors , 1992, Journal of abnormal child psychology.

[39]  J. Schweitzer,et al.  Self-control in boys with attention deficit hyperactivity disorder: effects of added stimulation and time. , 1995, Journal of child psychology and psychiatry, and allied disciplines.

[40]  B. Pennington,et al.  Executive functions and developmental psychopathology. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[41]  G. Lyon,et al.  Attention, Memory, and Executive Function , 1995 .

[42]  J. Sergeant,et al.  Inhibition in ADHD, aggressive, and anxious children: A biologically based model of child psychopathology , 1996, Journal of abnormal child psychology.

[43]  Benjamin B. Lahey,et al.  Advances in Clinical Child Psychology , 1980, Advances in Clinical Child Psychology.

[44]  F. Earls,et al.  Psychometric properties of impulsivity measures: temporal stability, validity and factor structure. , 1995, Journal of child psychology and psychiatry, and allied disciplines.

[45]  T. Shelton,et al.  Multimethod Assessment of Attention-Deficit Hyperactivity Disorder: The Diagnostic Utility of Clinic-Based Tests , 1992 .

[46]  M. Denckla,et al.  Measurement of executive function. , 1994 .

[47]  R. Pihl,et al.  Cognitive and neuropsychological characteristics of physically aggressive boys. , 1995, Journal of abnormal psychology.

[48]  Gordon D. Logan,et al.  Effects of methylphenidate on inhibitory control in hyperactive children , 1989, Journal of abnormal child psychology.

[49]  H. Quay,et al.  Response perseveration, inhibitory control, and central dopaminergic activity in childhood behavior disorders. , 1993, The Journal of genetic psychology.

[50]  W. Grant Willis,et al.  Executive functions in school‐aged children: Potential efficacy of tasks in discriminating clinical groups , 1994 .

[51]  T. Carr,et al.  Inhibitory Processes in Attention, Memory and Language , 1994 .

[52]  A. Sanders.  Issues and trends in the debate on discrete vs. continuous processing of information , 1990 .

[53]  J. Meere,et al.  Toward an Empirical Child Psychopathology , 1994 .

[54]  R. Loeber,et al.  Which boys will fare worse? Early predictors of the onset of conduct disorder in a six-year longitudinal study. , 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

[55]  S. Faraone,et al.  Comorbidity between ADDH and learning disability: a review and report in a clinically referred sample. , 1992, Journal of the American Academy of Child and Adolescent Psychiatry.

[56]  J. Gray,et al.  The psychology of fear and stress , 1971 .

[57]  C. Hartung,et al.  Behavioral Disinhibition and Underlying Processes in Adolescents with Disruptive Behavior Disorders , 1994 .

[58]  A. G. Baker,et al.  Effects of reward and response costs on inhibition in ADHD children. , 1995, Journal of abnormal psychology.

[59]  J. Fisher,et al.  Neuropsychological Assessment, 2nd Ed , 1985 .

[60]  S. Hinshaw.  On the distinction between attentional deficits/hyperactivity and conduct problems/aggression in child psychopathology. , 1987, Psychological bulletin.

[61]  Larry B. Silver,et al.  Attention Deficit Hyperactivity Disorder. A Handbook for Diagnosis and Treatment , 1991 .

[62]  J. Newman,et al.  Diverse pathways to deficient self-regulation: Implications for disinhibitory psychopathology in children , 1993 .

[63]  R. Barkley.  Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. , 1997, Psychological bulletin.

[64]  H. Quay.  Inhibition and Attention Deficit Hyperactivity Disorder , 1997, Journal of abnormal child psychology.

[65]  G. Reid Lyon,et al.  Frames of reference for the assessment of learning disabilities : new views on measurement issues , 1994 .

[66]  G D Logan,et al.  Strategies and mechanisms in nonselective and selective inhibitory motor control. , 1995, Journal of experimental psychology. Human perception and performance.

[67]  S. Sandberg.  Monographs on child and adolescent psychiatry: Hyperactivity disorders of childhood , 1996 .

[68]  H. Quay.  The behavioral reward and inhibition system in childhood behavior disorder. , 1988 .

[69]  J. Biederman,et al.  Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. , 1991, The American journal of psychiatry.

[70]  Russell A. Barkley,et al.  Linkages between attention and executive functions. , 1996 .

[71]  L J Horwood,et al.  Confirmatory factor models of attention deficit and conduct disorder. , 1991, Journal of child psychology and psychiatry, and allied disciplines.

[72]  M. Eysenck,et al.  Anxiety and Performance: The Processing Efficiency Theory , 1992 .

[73]  Brian Mullen,et al.  Advanced BASIC meta-analysis , 1989 .

[74]  S. Sternberg.  Memory-scanning: mental processes revealed by reaction-time experiments. , 1969, American scientist.

[75]  D. Farrington.  Motivations for conduct disorder and delinquency , 1993, Development and Psychopathology.

[76]  C. Edelbrock,et al.  The classification of child psychopathology: a review and analysis of empirical efforts. , 1978, Psychological bulletin.

[77]  G. Logan,et al.  Impulsivity and Inhibitory Control in Normal Development and Childhood Psychopathology , 1990 .

[78]  V. Douglas,et al.  Attention deficit hyperactivity disorder and the frontal lobe syndrome , 1992, Brain and Cognition.

[79]  R. Rosenthal.  Meta-analytic procedures for social research , 1984 .

[80]  D. Beidel,et al.  Comorbidity of childhood anxiety and externalizing disorders: Prevalence, associated characteristics, and validation issues , 1994 .

[81]  E. Taylor,et al.  Hyperactivity and conduct problems as risk factors for adolescent development. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[82]  J. J. van der Meere,et al.  Effects of Presentation Rate of Stimuli on Response Inhibition in ADHD Children with and without Tics , 1995, Perceptual and motor skills.

[83]  M. Gordon,et al.  Performance of disturbed hyperactive and nonhyperactive children on an objective measure of hyperactivity , 1984, Journal of abnormal child psychology.

[84]  Saul Sternberg,et al.  The discovery of processing stages: Extensions of Donders' method , 1969 .

[85]  R. Diamond,et al.  Frontal lobe functioning in boys with attention‐deficit hyperactivity disorder , 1992 .

[86]  R. Tannock,et al.  Test of four hypotheses for the comorbidity of attention-deficit hyperactivity disorder and conduct disorder. , 1995, Journal of the American Academy of Child and Adolescent Psychiatry.

[87]  R. Barkley.  Impaired Delayed Responding , 1994 .