Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
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S. Vatner | J. Sadoshima | T. Wagner | P. Zhai | Bin Tian | E. Holle | Xianzhong Yu | Daniela K. Zablocki | Shumin Gao | Ralph R. Alcendor
[1] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[2] J. Sadoshima,et al. Thioredoxin and ventricular remodeling. , 2006, Journal of molecular and cellular cardiology.
[3] Judit Villén,et al. A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span , 2006, Cell.
[4] S. Imai,et al. Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2α Deacetylase Activity* , 2005, Journal of Biological Chemistry.
[5] T. Finkel. Radical medicine: treating ageing to cure disease , 2005, Nature Reviews Molecular Cell Biology.
[6] Chao Cheng,et al. Sir2 Blocks Extreme Life-Span Extension , 2005, Cell.
[7] Matt Kaeberlein,et al. Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.
[8] D. Roden,et al. Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice , 2005 .
[9] Siegfried Hekimi,et al. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. , 2005, Genes & development.
[10] Izumi Horikawa,et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. , 2005, Molecular biology of the cell.
[11] Animesh Nandi,et al. Suppression of Aging in Mice by the Hormone Klotho , 2005, Science.
[12] P. Anversa. Aging and longevity: the IGF-1 enigma. , 2005, Circulation research.
[13] D. Sinclair. Toward a unified theory of caloric restriction and longevity regulation , 2005, Mechanisms of Ageing and Development.
[14] M. Permutt,et al. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. , 2005, Cell metabolism.
[15] Michael M. Murphy,et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. , 2005, Cell metabolism.
[16] M. Emond,et al. Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria , 2005, Science.
[17] Christian Néri,et al. Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons , 2005, Nature Genetics.
[18] C. Kenyon. The Plasticity of Aging: Insights from Long-Lived Mutants , 2005, Cell.
[19] S. Nemoto,et al. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway , 2004, Science.
[20] R. Bodmer,et al. Insulin regulation of heart function in aging fruit flies , 2004, Nature Genetics.
[21] S. Vatner,et al. Silent Information Regulator 2&agr;, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes , 2004, Circulation research.
[22] N. Sharpless,et al. Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.
[23] Myriam Gorospe,et al. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase , 2004, Science.
[24] L. Guarente,et al. The Sir2 family of protein deacetylases. , 2004, Annual review of biochemistry.
[25] Steven P. Gygi,et al. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase , 2004, Science.
[26] Mark A Sussman,et al. Myocardial aging and senescence: where have the stem cells gone? , 2004, Annual review of physiology.
[27] D. Torella,et al. Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration , 2003, Cell.
[28] Phuong Chung,et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan , 2003, Nature.
[29] F. Alt,et al. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[30] Cori Bargmann,et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans , 2003, Nature.
[31] S. Vatner,et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. , 2003, The Journal of clinical investigation.
[32] Deepayan Sarkar,et al. Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart. , 2003, Physiological genomics.
[33] M. Tatar,et al. The Endocrine Regulation of Aging by Insulin-like Signals , 2003, Science.
[34] J. Denu,et al. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. , 2003, Molecular cell.
[35] L. Guarente,et al. How does calorie restriction work? , 2003, Genes & development.
[36] Edward G Lakatta,et al. Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part III: Cellular and Molecular Clues to Heart and Arterial Aging , 2003, Circulation.
[37] Daniel Levy,et al. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease. , 2003, Circulation.
[38] Martin Holzenberger,et al. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.
[39] P. Lansdorp,et al. The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis , 2003, Molecular and Cellular Biology.
[40] P. Lansdorp,et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. , 2003, Molecular and cellular biology.
[41] Geert J. P. L. Kops,et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress , 2002, Nature.
[42] Tadashi Hirakawa,et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. , 2002, Antioxidants & redox signaling.
[43] G. Fink,et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration , 2002, Nature.
[44] V. Longo,et al. Regulation of Longevity and Stress Resistance by Sch9 in Yeast , 2001, Science.
[45] L. Guarente,et al. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans , 2001, Nature.
[46] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[47] P. Defossez,et al. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. , 2000, Science.
[48] L. Guarente,et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.
[49] Pier Paolo Pandolfi,et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.
[50] S. Vatner,et al. β-Adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse , 1999 .
[51] V. Longo. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells , 1999, Neurobiology of Aging.
[52] S. Vatner,et al. Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouse. , 1999, The Journal of clinical investigation.
[53] Koutarou D. Kimura,et al. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.
[54] P. Anversa,et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. , 1996, The American journal of physiology.
[55] H. Kolb,et al. Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion. , 1994, Biochemical and biophysical research communications.
[56] H. Schunkert,et al. Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium. , 1992, The Journal of clinical investigation.