Positron emission tomography and colorectal cancer.

Colorectal cancer (CRC) is a major cause of cancer-related morbidity and mortality. Molecular imaging using positron emission tomography (PET) is now an integral part of multidisciplinary cancer care. In this review, we discuss the role of PET in CRC including well established indications in the assessment of recurrent disease and emerging applications such as initial staging, monitoring therapy efficacy and using PET for radiotherapy planning. With rapid advancement in imaging technology, we also discuss the future potential of combining PET and magnetic resonance imaging and the use of novel radiotracers.

[1]  A. Hogg,et al.  The Impact of 18-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography on the Staging and Management of Primary Rectal Cancer , 2008, Diseases of the colon and rectum.

[2]  Jean-Claude Liehn,et al.  Positron Emission Tomography in oncology: present and future of PET and PET/CT. , 2009, Critical reviews in oncology/hematology.

[3]  H. Biersack,et al.  Possible role of FDG-PET in the early prediction of therapy outcome in liver metastases of colorectal cancer. , 1999, Hybridoma.

[4]  N. Avril 18F-FDG PET after radiofrequency ablation: Is timing everything? , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  Dow-Mu Koh,et al.  The use of 18F-FDG PET/CT in colorectal liver metastases—comparison with CT and liver MRI , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[6]  Antonio Rodríguez-Fernández,et al.  Fluorine-18 fluorodeoxyglucose PET in the preoperative staging of colorectal cancer , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  S S Gambhir,et al.  A meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancer. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[8]  Stewart Spies,et al.  Use of molecular imaging to predict clinical outcome in patients with rectal cancer after preoperative chemotherapy and radiation. , 2009, International journal of radiation oncology, biology, physics.

[9]  M. Lonneux,et al.  FDG-PET improves the staging and selection of patients with recurrent colorectal cancer , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[10]  S. Raman,et al.  Evaluating 90Y-glass microsphere treatment response of unresectable colorectal liver metastases by [18F]FDG PET: a comparison with CT or MRI , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[11]  B. Siegel,et al.  Unique site- and time-specific patterns of recurrence following resection of colorectal carcinoma hepatic metastases in patients staged by FDG-PET. , 2008, Journal of hepato-biliary-pancreatic surgery.

[12]  R. Hicks,et al.  Does positron emission tomography change management in primary rectal cancer? A prospective assessment , 2004, Diseases of the colon and rectum.

[13]  W. Oyen,et al.  Chemotherapy response evaluation with FDG-PET in patients with colorectal cancer. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[14]  S. Larson,et al.  Positron Emission Tomography Detection of Distant Metastatic or Synchronous Disease in Patients with Locally Advanced Rectal Cancer Receiving Preoperative Chemoradiation , 2008, Annals of Surgical Oncology.

[15]  B. Siegel,et al.  Utility of FDG-PET for investigating unexplained plasma CEA elevation in patients with colorectal cancer. , 1998, Annals of surgery.

[16]  A. Cuocolo,et al.  FGD‐PET in the follow‐up of recurrent colorectal cancer , 2003, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[17]  L. Schwartz,et al.  New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). , 2009, European journal of cancer.

[18]  M. Choti,et al.  NCCN Clinical Practice Guidelines in Oncology: colon cancer. , 2009, Journal of the National Comprehensive Cancer Network : JNCCN.

[19]  P. Flamen,et al.  Multimodality imaging can predict the metabolic response of unresectable colorectal liver metastases to radioembolization therapy with Yttrium-90 labeled resin microspheres , 2008, Physics in medicine and biology.

[20]  J. Stoker,et al.  Comparison of MRI (including SS SE-EPI and SPIO-enhanced MRI) and FDG-PET/CT for the detection of colorectal liver metastases , 2009, European Radiology.

[21]  Frederik Maes,et al.  Biological image-guided radiotherapy in rectal cancer: challenges and pitfalls. , 2009, International journal of radiation oncology, biology, physics.

[22]  Rodney J Hicks,et al.  Findings on 18F-FDG PET scans after neoadjuvant chemoradiation provides prognostic stratification in patients with locally advanced rectal carcinoma subsequently treated by radical surgery. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  M. Mukai,et al.  Preoperative evaluation by whole-body 18F-fluorodeoxyglucose positron emission tomography in patients with primary colorectal cancer. , 2000, Oncology reports.

[24]  Y. Taki,et al.  Usefulness of FDG-positron emission tomography in diagnosing peritoneal recurrence of colorectal cancer. , 2002, American journal of surgery.

[25]  S. Goldman,et al.  [F‐18] Fluorodeoxyglucose positron emission tomography as a tool for early recognition of incomplete tumor destruction after radiofrequency ablation for liver metastases , 2003, Journal of surgical oncology.

[26]  K. Chan,et al.  A method of reporting radial invasion and surgical clearance of rectal carcinoma , 1985, Histopathology.

[27]  Thomas Beyer,et al.  Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  F. Orsi,et al.  Role of [18F]FDG-PET/CT after radiofrequency ablation of liver metastases: preliminary results , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[29]  Leyun Pan,et al.  Impact of Angiogenesis-Related Gene Expression on the Tracer Kinetics of 18F-FDG in Colorectal Tumors , 2008, Journal of Nuclear Medicine.

[30]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[31]  A. Hogg,et al.  The Clinical Impact of 18F-FDG PET in Patients with Suspected or Confirmed Recurrence of Colorectal Cancer: A Prospective Study , 2002 .

[32]  Patrick M M Bossuyt,et al.  Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis. , 2004, Radiology.

[33]  D. Rubello,et al.  Long-term prognostic value of 18F-FDG PET in patients with locally advanced rectal cancer previously treated with neoadjuvant radiochemotherapy. , 2006, AJR. American journal of roentgenology.

[34]  J. Fleshman,et al.  Usefulness of FDG-PET scan in the assessment of suspected metastatic or recurrent adenocarcinoma of the colon and rectum , 2000, Diseases of the colon and rectum.

[35]  Barry A Siegel,et al.  Impact of positron emission tomography/computed tomography and positron emission tomography (PET) alone on expected management of patients with cancer: initial results from the National Oncologic PET Registry. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  H. Abdel-Nabi,et al.  Staging of primary colorectal carcinomas with fluorine-18 fluorodeoxyglucose whole-body PET: correlation with histopathologic and CT findings. , 1998, Radiology.

[37]  W. Oyen,et al.  The impact of fluor‐18‐deoxyglucose‐positron emission tomography in the management of colorectal liver metastases , 2005, Cancer.

[38]  S. Gallinger,et al.  Survival After Hepatic Resection for Colorectal Metastases: A 10-Year Experience , 2006, Annals of surgical oncology.

[39]  D. Lieberman Colon cancer screening and surveillance controversies , 2009, Current opinion in gastroenterology.

[40]  D. Cunningham,et al.  Treatment in advanced colorectal cancer: what, when and how? , 2009, British Journal of Cancer.

[41]  R. Wahl,et al.  From RECIST to PERCIST: Evolving Considerations for PET Response Criteria in Solid Tumors , 2009, Journal of Nuclear Medicine.

[42]  M. Schwaiger,et al.  PET imaging with [18F]3′-deoxy-3′-fluorothymidine for prediction of response to neoadjuvant treatment in patients with rectal cancer , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[43]  B. Cooper,et al.  Detection of clinically unexpected malignant and premalignant tumors with whole-body FDG PET: histopathologic comparison. , 2004, Radiology.

[44]  T. Yen,et al.  Utility of 2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Managing Patients of Colorectal Cancer With Unexplained Carcinoembryonic Antigen Elevation at Different Levels , 2005, Diseases of the colon and rectum.

[45]  D. Ruysscher,et al.  Can an FDG-PET/CT Predict Tumor Clearance of the Mesorectal Fascia after Preoperative Chemoradiation of Locally Advanced Rectal Cancer? , 2008, Strahlentherapie und Onkologie.

[46]  T. Kato,et al.  Recurrent rectal cancer and scar: differentiation with PET and MR imaging. , 1992, Radiology.

[47]  A. Zwinderman,et al.  Colorectal liver metastases: CT, MR imaging, and PET for diagnosis--meta-analysis. , 2005, Radiology.

[48]  A. Figer,et al.  Response to chemotherapy predicts survival following resection of hepatic colo‐rectal metastases in patients treated with neoadjuvant therapy , 2009, Journal of surgical oncology.

[49]  T. Hickish,et al.  Colorectal tubulovillous adenomas identified on fluoro‐2‐deoxy‐d‐glucose positron emission tomography/computed tomography scans , 2008, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[50]  P. Quirke,et al.  Role of circumferential margin involvement in the local recurrence of rectal cancer , 1994, The Lancet.

[51]  P. Wust,et al.  Comparison of CT, MRI and FDG-PET in response prediction of patients with locally advanced rectal cancer after multimodal preoperative therapy: Is there a benefit in using functional imaging? , 2005, European Radiology.

[52]  R. Hicks,et al.  Radiation changes do not interfere with postchemoradiation restaging of patients with rectal cancer by FDG PET/CT before curative surgical therapy. , 2009, International journal of radiation oncology, biology, physics.

[53]  J. Humm,et al.  Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer. , 2001, Neoplasia.

[54]  T. Eglinton,et al.  Positron‐emission tomography/computed tomography (PET/CT) in the initial staging of primary rectal cancer , 2009, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[55]  N. Willich,et al.  Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer , 2009, Strahlentherapie und Onkologie.

[56]  G. Antoch,et al.  Comparison of FDG-PET, PET/CT and MRI for follow-up of colorectal liver metastases treated with radiofrequency ablation : Initial results , 2008 .

[57]  W. Oyen,et al.  Efficacy of fluorine-18-deoxyglucose positron emission tomography in detecting tumor recurrence after local ablative therapy for liver metastases: a prospective study. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[58]  T. Helmberger,et al.  Selective internal radiation therapy with SIR-Spheres in patients with nonresectable liver tumors. , 2005, Cancer biotherapy & radiopharmaceuticals.

[59]  Gerald Antoch,et al.  Detection of residual tumor after radiofrequency ablation of liver metastasis with dual-modality PET/CT: initial results , 2005, European Radiology.

[60]  S. Larson,et al.  18F-FDG PET Scanning Correlates with Tissue Markers of Poor Prognosis and Predicts Mortality for Patients After Liver Resection for Colorectal Metastases , 2007, Journal of Nuclear Medicine.

[61]  D. Mahvi,et al.  Clinical risk score correlates with yield of PET scan in patients with colorectal hepatic metastases , 2003, Journal of Gastrointestinal Surgery.

[62]  A. Figer,et al.  Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection. , 2004, Radiology.

[63]  W. Oyen,et al.  Improved Selection of Patients for Hepatic Surgery of Colorectal Liver Metastases with 18F-FDG PET: A Randomized Study , 2009, Journal of Nuclear Medicine.

[64]  W. Oyen,et al.  FDG-PET for prediction of survival of patients with metastatic colorectal carcinoma. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[65]  S. Yuen,et al.  Positron emission tomography scanning is not superior to whole body multidetector helical computed tomography in the preoperative staging of colorectal cancer , 2005, Gut.

[66]  S. Nishizawa,et al.  Prospective evaluation of whole-body cancer screening with multiple modalities including [18F]fluorodeoxyglucose positron emission tomography in a healthy population: a preliminary report. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[67]  T. Hickish,et al.  Noninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: correlation with tumor response to fluorouracil. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[68]  W. Oyen,et al.  2-(18F)-fluoro-2-deoxy-D-glucose positron emission tomography detects clinical relevant adenomas of the colon: a prospective study. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[69]  S. Teramukai,et al.  Cancer screening of healthy volunteers using whole-body 18F-FDG-PET scans: The Nishidai clinic study. , 2007, European journal of cancer.

[70]  T. Muto,et al.  Comparison of preoperative whole‐body positron emission tomography with MDCT in patients with primary colorectal cancer , 2009, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[71]  B. Siegel,et al.  Chemotherapy-Induced Normalization of FDG Uptake by Colorectal Liver Metastases Does Not Usually Indicate Complete Pathologic Response , 2007, Journal of Gastrointestinal Surgery.

[72]  Otakar Belohlavek,et al.  Routine 18F-FDG PET Preoperative Staging of Colorectal Cancer: Comparison with Conventional Staging and Its Impact on Treatment Decision Making , 2003 .

[73]  P. Quirke,et al.  LOCAL RECURRENCE OF RECTAL ADENOCARCINOMA DUE TO INADEQUATE SURGICAL RESECTION Histopathological Study of Lateral Tumour Spread and Surgical Excision , 1986, The Lancet.

[74]  Peter M. Schlag,et al.  Response prediction by FDG-PET after neoadjuvant radiochemotherapy and combined regional hyperthermia of rectal cancer: correlation with endorectal ultrasound and histopathology , 2004, European Journal of Nuclear Medicine and Molecular Imaging.

[75]  Sanjiv S. Gambhir,et al.  Impact of Integrated PET/CT on Variability of Target Volume Delineation in Rectal Cancer , 2007, Technology in cancer research & treatment.

[76]  J. Beatty,et al.  Incidental PET/CT findings in the cancer patient: how should they be managed? , 2009, Surgery.

[77]  N. Petrelli,et al.  A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[78]  J. Humm,et al.  Prospective assessment of primary rectal cancer response to preoperative radiation and chemotherapy using 18-fluorodeoxyglucose positron emission tomography , 2000, Diseases of the colon and rectum.

[79]  M. Taupitz,et al.  Local staging of rectal cancer: the current role of MRI , 2006, European Radiology.

[80]  Kumar,et al.  Rectal cancer recurrence: factors and mechanisms , 2000, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[81]  P. D. Peppercorn,et al.  Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study , 2006, BMJ : British Medical Journal.

[82]  Karin Haustermans,et al.  PET-based treatment planning in radiotherapy: a new standard? , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[83]  M. Schwaiger,et al.  PET imaging with [11C]methyl-L-methionine for therapy monitoring in patients with rectal cancer , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[84]  Assessment of local control after laser-induced thermotherapy of liver metastases from colorectal cancer: contribution of FDG-PET in patients with clinical suspicion of progressive disease , 2007, Acta radiologica.

[85]  R. Manoliu,et al.  Results of radio frequency ablation of primary and secondary liver tumors: long-term follow-up with computed tomography and positron emission tomography-18F-deoxyfluoroglucose scanning , 2004, Scandinavian journal of gastroenterology. Supplement.

[86]  Robert J Myerson,et al.  Tumor Hypoxia Detected by Positron Emission Tomography with 60Cu-ATSM as a Predictor of Response and Survival in Patients Undergoing Neoadjuvant Chemoradiotherapy for Rectal Carcinoma: A Pilot Study , 2008, Diseases of the colon and rectum.

[87]  A. Pecking,et al.  Incidental colonic focal lesions detected by FDG PET/CT. , 2005, AJR. American journal of roentgenology.

[88]  C. Claussen,et al.  Simultaneous Mr/pet Imaging of the Human Brain: Feasibility Study 1 , 2022 .

[89]  N. Habib,et al.  Assessment of response to treatment of unresectable liver tumours with 90Y microspheres: Value of FDG PET versus computed tomography , 2007, Nuclear medicine communications.

[90]  W. Oyen,et al.  Increased Metabolic Activity of Indolent Liver Metastases After Resection of a Primary Colorectal Tumor , 2008, Journal of Nuclear Medicine.

[91]  Cyrill Burger,et al.  Automated functional image-guided radiation treatment planning for rectal cancer. , 2005, International journal of radiation oncology, biology, physics.

[92]  N. Nishiumi,et al.  18F-FDG PET detection of colonic adenomas. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[93]  S. Kudo,et al.  PET/CT Colonography for the Preoperative Evaluation of the Colon Proximal to the Obstructive Colorectal Cancer , 2008, Diseases of the colon and rectum.

[94]  K. Sugimura,et al.  Performance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: Comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CT , 2008, European Journal of Nuclear Medicine and Molecular Imaging.

[95]  Tim Fox,et al.  PET-CT fusion in radiation management of patients with anorectal tumors. , 2007, International journal of radiation oncology, biology, physics.

[96]  T. Fleming,et al.  Surgery for Recurrent Colon Cancer: Strategies for Identifying Resectable Recurrence and Success Rates after Resection , 1998, Annals of Internal Medicine.

[97]  Hiroshi Fukuda,et al.  Performance profile of FDG-PET and PET/CT for cancer screening on the basis of a Japanese Nationwide Survey , 2007, Annals of nuclear medicine.

[98]  Frederik Maes,et al.  Biological image-guided radiotherapy in rectal cancer: Is there a role for FMISO or FLT, next to FDG? , 2008, Acta oncologica.

[99]  O. Belohlávek,et al.  The role of FDG-PET/CT in the detection of recurrent colorectal cancer , 2006, European Journal of Nuclear Medicine and Molecular Imaging.

[100]  Yasuaki Arai,et al.  Non-enhanced CT versus contrast-enhanced CT in integrated PET/CT studies for nodal staging of rectal cancer , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[101]  I. Sobhani,et al.  Early detection of recurrence by 18FDG-PET in the follow-up of patients with colorectal cancer , 2008, British Journal of Cancer.

[102]  L H Blumgart,et al.  Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. , 1999, Annals of surgery.

[103]  Cesare Guida,et al.  18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[104]  D. Elias,et al.  Staging of peritoneal carcinomatosis: enhanced CT vs. PET/CT , 2007, Abdominal Imaging.

[105]  L. Bonomo,et al.  Imaging of peritoneal carcinomatosis with FDG PET-CT: diagnostic patterns, case examples and pitfalls , 2009, Abdominal Imaging.

[106]  P Schmidlin,et al.  Recurrence of colorectal tumors: PET evaluation. , 1989, Radiology.

[107]  L. Mortelmans,et al.  Clinical value of whole‐body positron emission tomography with [18F]fluorodeoxyglucose in recurrent colorectal cancer , 1994, The British journal of surgery.

[108]  J S Fowler,et al.  Increased accumulation of 2-deoxy-2-[18F]Fluoro-D-glucose in liver metastases from colon carcinoma. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[109]  David W Barker,et al.  Evaluation of liver metastases after radiofrequency ablation: utility of 18F-FDG PET and PET/CT. , 2005, AJR. American journal of roentgenology.

[110]  J. Guillem,et al.  Surgical Salvage of Recurrent Rectal Carcinoma After Curative Resection: a 10-Year Experience , 1999, Annals of Surgical Oncology.

[111]  J. Tepper,et al.  Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from Intergroup Study 0114. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[112]  A. Sundin,et al.  Early prediction of response to first-line chemotherapy by sequential [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography in patients with advanced colorectal cancer. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

[113]  R. Salem,et al.  Reduction of metastatic load to liver after intraarterial hepatic yttrium-90 radioembolization as evaluated by [18F]fluorodeoxyglucose positron emission tomographic imaging. , 2005, Journal of vascular and interventional radiology : JVIR.

[114]  W. Oyen,et al.  Cryosurgery and radiofrequency ablation for unresectable colorectal liver metastases. , 2005, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[115]  Simon R Cherry,et al.  Multimodality imaging: beyond PET/CT and SPECT/CT. , 2009, Seminars in nuclear medicine.

[116]  M. Choti,et al.  Efficacy of Preoperative Combined 18-Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography for Assessing Primary Rectal Cancer Response to Neoadjuvant Therapy , 2007, Journal of Gastrointestinal Surgery.

[117]  G. V. von Schulthess,et al.  Significance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic results. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[118]  E. Martin,et al.  Fluorodeoxyglucose positron emission tomography as an adjunct to carcinoembryonic antigen in the management of patients with presumed recurrent colorectal cancer and nondiagnostic radiologic workup. , 2001, Surgery.

[119]  A. Di Cataldo,et al.  Colorectal cancer follow-up: useful or useless? , 2006, Surgical oncology.

[120]  Cyrill Burger,et al.  Radiation treatment planning with an integrated positron emission and computer tomography (PET/CT): a feasibility study. , 2003, International journal of radiation oncology, biology, physics.

[121]  Marco Brambilla,et al.  FDG-PET/CT imaging for staging and target volume delineation in preoperative conformal radiotherapy of rectal cancer. , 2008, International journal of radiation oncology, biology, physics.

[122]  P. Valk,et al.  Impact of 18F-FDG PET on managing patients with colorectal cancer: the referring physician's perspective. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[123]  Françoise Kraeber-Bodéré,et al.  Does 18F-FDG PET/CT Improve the Detection of Posttreatment Recurrence of Head and Neck Squamous Cell Carcinoma in Patients Negative for Disease on Clinical Follow-up? , 2008, Journal of Nuclear Medicine.

[124]  A. R. Ravi Kumar,et al.  The segmental distribution and clinical significance of colorectal fluorodeoxyglucose uptake incidentally detected on PET-CT , 2009, Nuclear medicine communications.

[125]  A. Cruz,et al.  Results of a 400‐patient carcinoembryonic antigen second‐look colorectal cancer study , 1985, Cancer.

[126]  F. Guillemin,et al.  Use of a decision analysis model to assess the cost-effectiveness of 18F-FDG PET in the management of metachronous liver metastases of colorectal cancer. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[127]  S. Yasuda,et al.  Cancer screening with whole-body F-fluorodeoxyglucose positron-emission tomography , 1997, The Lancet.

[128]  D. Morris,et al.  Resection of liver metastases from colorectal cancer: does preoperative chemotherapy affect the accuracy of PET in preoperative planning? , 2009, ANZ journal of surgery.

[129]  Michael J Fulham,et al.  PET Changes Management and Improves Prognostic Stratification in Patients with Recurrent Colorectal Cancer: Results of a Multicenter Prospective Study , 2008, Journal of Nuclear Medicine.

[130]  M. Inbar,et al.  The presentation of malignant tumours and pre-malignant lesions incidentally found on PET-CT , 2006, European Journal of Nuclear Medicine and Molecular Imaging.

[131]  M. Knopp,et al.  FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA , 2007, World journal of surgical oncology.

[132]  H. Biersack,et al.  Fluorodeoxyglucose whole-body positron emission tomography in colorectal cancer patients studied in routine daily practice , 1997, Diseases of the colon and rectum.

[133]  Heinrich R Schelbert,et al.  Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[134]  A. Alavi,et al.  FDG Positron Emission Tomography in the Surveillance of Hepatic Tumors Treated with Radiofrequency Ablation , 2003, Clinical nuclear medicine.

[135]  S. Zwas,et al.  PET/CT in the Evaluation of Response to Treatment of Liver Metastases from Colorectal Cancer with Bevacizumab and Irinotecan , 2006, Technology in cancer research & treatment.

[136]  J. H. Kim,et al.  Efficacy of PET/CT in the accurate evaluation of primary colorectal carcinoma. , 2006, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[137]  B. Siegel,et al.  Five-Year Survival After Resection of Hepatic Metastases From Colorectal Cancer in Patients Screened by Positron Emission Tomography With F-18 Fluorodeoxyglucose (FDG-PET) , 2004, Annals of surgery.

[138]  R. Wahl,et al.  Direct Comparison of 18F-FDG PET and PET/CT in Patients with Colorectal Carcinoma , 2003 .

[139]  M V Knopp,et al.  Image fusion using CT, MRI and PET for treatment planning, navigation and follow up in percutaneous RFA. , 2009, Experimental oncology.

[140]  M. Choti,et al.  Trends in Nontherapeutic Laparotomy Rates in Patients Undergoing Surgical Therapy for Hepatic Colorectal Metastases , 2009, Annals of Surgical Oncology.

[141]  R. Newcombe,et al.  Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. , 2003, Radiology.

[142]  R. Fitzgibbons,et al.  Patterns of recurrence after curative resection of carcinoma of the colon and rectum. , 1992, Surgery, gynecology & obstetrics.

[143]  R. Salem,et al.  Metabolic response after intraarterial 90Y-glass microsphere treatment for colorectal liver metastases: comparison of quantitative and visual analyses by 18F-FDG PET. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[144]  W. Schima,et al.  Detection of histologically proven peritoneal carcinomatosis with fused 18F-FDG-PET/MDCT. , 2009, European journal of radiology.

[145]  P. Lin,et al.  Positron emission tomography: current status and future challenges , 2010, Internal medicine journal.

[146]  A. Hölscher,et al.  Lymph Node Size and Metastatic Infiltration in Colon Cancer , 1999, Annals of Surgical Oncology.

[147]  P. Dupont,et al.  Additional value of whole-body positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose in recurrent colorectal cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[148]  P. Grigsby,et al.  Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer. , 2009, Gynecologic Oncology.

[149]  K. Herholz,et al.  Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group. , 1999, European journal of cancer.

[150]  M. Choti,et al.  Improved Staging With Pretreatment Positron Emission Tomography/Computed Tomography in Low Rectal Cancer , 2006, Annals of Surgical Oncology.

[151]  S. Nawano,et al.  Positron emission tomography with F-18 fluorodeoxyglucose in evaluating colorectal hepatic metastasis down-staged by chemotherapy. , 2006, Anticancer research.

[152]  L. Strauss,et al.  PET-FDG as predictor of therapy response in patients with colorectal carcinoma. , 2003, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

[153]  C. Hamashima,et al.  Evaluation of whole-body cancer screening using 18F-2-deoxy-2-fluoro-d-glucose positron emission tomography: a preliminary report , 2008, Annals of nuclear medicine.

[154]  Z. Keidar,et al.  PET/CT detection of unexpected gastrointestinal foci of 18F-FDG uptake: incidence, localization patterns, and clinical significance. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[155]  T. Beyer,et al.  Diagnostic accuracy of colorectal cancer staging with whole-body PET/CT colonography. , 2006, JAMA.

[156]  Cyrill Burger,et al.  Prognostic aspects of 18F-FDG PET kinetics in patients with metastatic colorectal carcinoma receiving FOLFOX chemotherapy. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[157]  S. Berlangieri,et al.  Role of Low-dose, Noncontrast Computed Tomography from Integrated Positron Emission Tomography/Computed Tomography in Evaluating Incidental 2-Deoxy-2-[F-18]fluoro-d-glucose-avid Colon Lesions , 2007, Molecular Imaging and Biology.

[158]  N. Avril,et al.  90Y microsphere treatment of unresectable liver metastases: changes in 18F-FDG uptake and tumour size on PET/CT , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[159]  B. Siegel,et al.  Survival of Patients Evaluated by FDG-PET Before Hepatic Resection for Metastatic Colorectal Carcinoma: A Prospective Database Study , 2001, Annals of surgery.

[160]  M. Mauro,et al.  A pilot study of early 18F-FDG PET to evaluate the effectiveness of radiofrequency ablation of liver metastases. , 2007, AJR. American journal of roentgenology.

[161]  A. Figer,et al.  The Role and Limitations of 18-Fluoro-2-deoxy-d-glucose Positron Emission Tomography (FDG-PET) Scan and Computerized Tomography (CT) in Restaging Patients with Hepatic Colorectal Metastases Following Neoadjuvant Chemotherapy: Comparison with Operative and Pathological Findings , 2007, Journal of Gastrointestinal Surgery.

[162]  D. Lee,et al.  Correlation between serum CEA level and metabolic volume as determined by FDG PET in postoperative patients with recurrent colorectal cancer , 2005, Annals of nuclear medicine.

[163]  E. Van Cutsem,et al.  Primary colon cancer: ESMO clinical recommendations for diagnosis, adjuvant treatment and follow-up. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

[164]  S. Larson,et al.  Recent chemotherapy reduces the sensitivity of [18F]fluorodeoxyglucose positron emission tomography in the detection of colorectal metastases. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.