Polarization and Movement of Keratocytes: A Multiscale Modelling Approach

[1]  Alexandra Jilkine,et al.  Mathematical Model for Spatial Segregation of the Rho-Family GTPases Based on Inhibitory Crosstalk , 2007, Bulletin of mathematical biology.

[2]  Leah Edelstein-Keshet,et al.  Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. , 2007, Biophysical journal.

[3]  A. Coniglio,et al.  Diffusion-limited phase separation in eukaryotic chemotaxis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Shin Ishii,et al.  A molecular model for axon guidance based on cross talk between rho GTPases. , 2005, Biophysical journal.

[5]  A. Kenworthy,et al.  Ras diffusion is sensitive to plasma membrane viscosity. , 2005, Biophysical journal.

[6]  A. Narang Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways. , 2005, Journal of theoretical biology.

[7]  Giovanni Dietler,et al.  Gradient of rigidity in the lamellipodia of migrating cells revealed by atomic force microscopy. , 2005, Biophysical journal.

[8]  Richard A. Cerione,et al.  The Cool-2/α-Pix Protein Mediates a Cdc42-Rac Signaling Cascade , 2005, Current Biology.

[9]  Yiider Tseng,et al.  Intracellular mechanics of migrating fibroblasts. , 2004, Molecular biology of the cell.

[10]  K. Hahn,et al.  Activation of Endogenous Cdc42 Visualized in Living Cells , 2004, Science.

[11]  Kazuo Sutoh,et al.  Keratocyte-like locomotion in amiB-null Dictyostelium cells. , 2004, Cell motility and the cytoskeleton.

[12]  P. Vallotton,et al.  Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Etienne-Manneville,et al.  Cdc42 - the centre of polarity , 2004, Journal of Cell Science.

[14]  Krister Wennerberg,et al.  Rho and Rac Take Center Stage , 2004, Cell.

[15]  Marten Postma,et al.  Chemotaxis: signalling modules join hands at front and tail , 2004, EMBO reports.

[16]  M. Matsuda,et al.  Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. , 2003, Molecular biology of the cell.

[17]  G. Somero,et al.  Influences of thermal acclimation and acute temperature change on the motility of epithelial wound-healing cells (keratocytes) of tropical, temperate and Antarctic fish , 2003, Journal of Experimental Biology.

[18]  Z. Kam,et al.  Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells , 2003, Journal of Cell Science.

[19]  T. Svitkina,et al.  Orientational order of the lamellipodial actin network as demonstrated in living motile cells. , 2003, Molecular biology of the cell.

[20]  Jingsong Xu,et al.  Divergent Signals and Cytoskeletal Assemblies Regulate Self-Organizing Polarity in Neutrophils , 2003, Cell.

[21]  R. Firtel,et al.  Two Poles and a Compass , 2003, Cell.

[22]  A. Mogilner,et al.  Analysis of actin dynamics at the leading edge of crawling cells: implications for the shape of keratocyte lamellipodia , 2003, European Biophysics Journal.

[23]  V. Fowler,et al.  Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility , 2003, The Journal of cell biology.

[24]  Emmanuelle Caron,et al.  Rac signalling: a radical view , 2003, Nature Cell Biology.

[25]  George Oster,et al.  Force generation by actin polymerization II: the elastic ratchet and tethered filaments. , 2003, Biophysical journal.

[26]  A. Carlsson Growth velocities of branched actin networks. , 2003, Biophysical journal.

[27]  H. Meinhardt Complex pattern formation by a self-destabilization of established patterns: chemotactic orientation and phyllotaxis as examples. , 2003, Comptes rendus biologies.

[28]  J. Hartwig,et al.  Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  E. Giniger How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics. , 2002, Differentiation; research in biological diversity.

[30]  Leah Edelstein-Keshet,et al.  Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. , 2002, Biophysical journal.

[31]  Richard A. Firtel,et al.  Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis , 2002, Cell.

[32]  R. Birge,et al.  ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts , 2002, The Journal of cell biology.

[33]  T. Takenawa,et al.  Spatial and temporal regulation of actin polymerization for cytoskeleton formation through Arp2/3 complex and WASP/WAVE proteins. , 2002, Cell motility and the cytoskeleton.

[34]  George Oster,et al.  How nematode sperm crawl. , 2002, Journal of cell science.

[35]  T D Pollard,et al.  Direct real-time observation of actin filament branching mediated by Arp2/3 complex using total internal reflection fluorescence microscopy , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[36]  A. Ridley,et al.  Rho family proteins: coordinating cell responses. , 2001, Trends in cell biology.

[37]  C. Waterman-Storer,et al.  Cell motility: can Rho GTPases and microtubules point the way? , 2001, Journal of cell science.

[38]  A. Carlsson,et al.  Growth of branched actin networks against obstacles. , 2001, Biophysical journal.

[39]  G. Borisy,et al.  Self-organization of a propulsive actin network as an evolutionary process , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. V. van Haastert,et al.  A diffusion-translocation model for gradient sensing by chemotactic cells. , 2001, Biophysical journal.

[41]  A. Levchenko,et al.  Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. , 2001, Biophysical journal.

[42]  A. Ridley Rho GTPases and cell migration. , 2001, Journal of cell science.

[43]  L. Segel,et al.  Computing an organism , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[44]  P. Hogeweg,et al.  How amoeboids self-organize into a fruiting body: Multicellular coordination in Dictyostelium discoideum , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Gary G. Borisy,et al.  Dendritic organization of actin comet tails , 2001, Current Biology.

[46]  David Michaelson,et al.  Differential Localization of Rho Gtpases in Live Cells , 2001, The Journal of cell biology.

[47]  T. Meyer,et al.  Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides , 2000, The Journal of cell biology.

[48]  D. Lawrence,et al.  Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension , 2000, The Journal of cell biology.

[49]  Mario Mellado,et al.  Role of the Pi3k Regulatory Subunit in the Control of Actin Organization and Cell Migration , 2000, The Journal of cell biology.

[50]  K. Hahn,et al.  Localized Rac activation dynamics visualized in living cells. , 2000, Science.

[51]  Thomas D. Pollard,et al.  Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex , 2000, The Journal of cell biology.

[52]  T Matozaki,et al.  Small G-protein networks: their crosstalk and signal cascades. , 2000, Cellular signalling.

[53]  R. Firtel,et al.  The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[54]  Toshio Yanagida,et al.  Single-Molecule Imaging of Signaling Molecules in Living Cells , 2000 .

[55]  John G. Collard,et al.  Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition , 2000, The Journal of cell biology.

[56]  J. Collins,et al.  Construction of a genetic toggle switch in Escherichia coli , 2000, Nature.

[57]  Michael P. Sheetz,et al.  Keratocytes Pull with Similar Forces on Their Dorsal and Ventral Surfaces , 1999, The Journal of cell biology.

[58]  John G. Collard,et al.  Rac Downregulates Rho Activity: Reciprocal Balance between Both Gtpases Determines Cellular Morphology and Migratory Behavior , 1999 .

[59]  G. Bokoch,et al.  A Role for P21-Activated Kinase in Endothelial Cell Migration , 1999, The Journal of cell biology.

[60]  Thomas D. Pollard,et al.  Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar Proteins* , 1999, The Journal of Biological Chemistry.

[61]  J. Cooper,et al.  Cdc42-induced actin filaments are protected from capping protein , 1999, Current Biology.

[62]  D. L. Taylor,et al.  The actin-based nanomachine at the leading edge of migrating cells. , 1999, Biophysical journal.

[63]  Gary G. Borisy,et al.  Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia , 1999, The Journal of cell biology.

[64]  G. Bokoch,et al.  Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases* , 1999, The Journal of Biological Chemistry.

[65]  C. Parent,et al.  A cell's sense of direction. , 1999, Science.

[66]  Alan Hall,et al.  Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement , 1999, The Journal of cell biology.

[67]  Gary G. Borisy,et al.  Self-polarization and directional motility of cytoplasm , 1999, Current Biology.

[68]  A. Wells,et al.  Epidermal growth factor receptor‐mediated motility in fibroblasts , 1998, Microscopy research and technique.

[69]  Daniel Zicha,et al.  A Role for Cdc42 in Macrophage Chemotaxis , 1998, The Journal of cell biology.

[70]  T D Pollard,et al.  The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[71]  Y. Zheng,et al.  Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1. , 1998, Biochemistry.

[72]  C. M. Cohen,et al.  Guanine nucleotide-dependent translocation of RhoA from cytosol to high affinity membrane binding sites in human erythrocytes. , 1998, The Biochemical journal.

[73]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[74]  K. Jacobson,et al.  The composition and dynamics of cell-substratum adhesions in locomoting fish keratocytes. , 1997, Journal of cell science.

[75]  John G. Collard,et al.  The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho , 1997, The Journal of cell biology.

[76]  Gary G. Borisy,et al.  Analysis of the Actin–Myosin II System in Fish Epidermal Keratocytes: Mechanism of Cell Body Translocation , 1997, The Journal of cell biology.

[77]  Ueli Aebi,et al.  Actin: From cell biology to atomic detail , 1997, Journal of structural biology.

[78]  T. Takubo,et al.  Distribution of myosin and actin in moving human neutrophils detected by double-fluorescence staining. , 1997, Analytical and quantitative cytology and histology.

[79]  Walter F. Stafford,et al.  Structure, Subunit Topology, and Actin-binding Activity of the Arp2/3 Complex from Acanthamoeba , 1997, The Journal of cell biology.

[80]  J. Exton,et al.  Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor* , 1996, The Journal of Biological Chemistry.

[81]  G. Oster,et al.  Cell motility driven by actin polymerization. , 1996, Biophysical journal.

[82]  G. Oster,et al.  The physics of lamellipodial protrusion , 1996, European Biophysics Journal.

[83]  M. Ehrengruber,et al.  Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility. , 1996, The Journal of experimental biology.

[84]  José C. M. Mombach,et al.  Quantitative comparison between differential adhesion models and cell sorting in the presence and absence of fluctuations. , 1995, Physical review letters.

[85]  J. Nicholls,et al.  Electrical activity, growth cone motility and the cytoskeleton. , 1995, The Journal of experimental biology.

[86]  C. Nobes,et al.  Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.

[87]  Christine E. Krewson,et al.  Cell aggregation and neurite growth in gels of extracellular matrix molecules , 1994, Biotechnology and bioengineering.

[88]  T. Mitchison,et al.  Actin-dependent motile forces and cell motility. , 1994, Current opinion in cell biology.

[89]  François Graner,et al.  Can Surface Adhesion Drive Cell-rearrangement? Part I: Biological Cell-sorting , 1993 .

[90]  Glazier,et al.  Simulation of the differential adhesion driven rearrangement of biological cells. , 1993, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[91]  Anne J. Ridley,et al.  The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.

[92]  D A Lauffenburger,et al.  Mathematical model for the effects of adhesion and mechanics on cell migration speed. , 1991, Biophysical journal.

[93]  Y. Nishiura Singular Limit Approach to Stability and Bifurcation for Bistable Reaction Diffusion Systems , 1991 .

[94]  M. Abercrombie,et al.  The Croonian Lecture, 1978 - The crawling movement of metazoan cells , 1980, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[95]  J. Leech,et al.  Classical Dynamics of Particles and Systems , 1966 .

[96]  N. Metropolis,et al.  Equation of State Calculations by Fast Computing Machines , 1953, Resonance.

[97]  William Hyde Wollaston,et al.  I. The Croonian Lecture , 1810, Philosophical Transactions of the Royal Society of London.

[98]  Leah Edelstein-Keshet,et al.  Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a 1 D model of a motile cell , 2006 .

[99]  Alex Mogilner,et al.  Multiscale Two-Dimensional Modeling of a Motile Simple-Shaped Cell , 2005, Multiscale Model. Simul..

[100]  A. Hall,et al.  Cell migration: Rho GTPases lead the way. , 2004, Developmental biology.

[101]  Hans G. Othmer,et al.  A continuum model of motility in ameboid cells , 2004, Bulletin of mathematical biology.

[102]  T. Pollard,et al.  Cellular Motility Driven by Assembly and Disassembly of Actin Filaments , 2003, Cell.

[103]  M. Einarson,et al.  Dissection of HEF1-dependent functions in motility and transcriptional regulation. , 2002, Journal of cell science.

[104]  T D Pollard,et al.  Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. , 2000, Annual review of biophysics and biomolecular structure.

[105]  S. Kuroda,et al.  Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. , 1999, Annual review of biochemistry.

[106]  L. Segel,et al.  Extending the quasi-steady state approximation by changing variables. , 1996, Bulletin of mathematical biology.

[107]  S. Zigmond,et al.  Distribution of F-actin elongation sites in lysed polymorphonuclear leukocytes parallels the distribution of endogenous F-actin. , 1993, Cell motility and the cytoskeleton.

[108]  K. Kaibuchi,et al.  Small GTP-binding proteins. , 1992, International review of cytology.

[109]  D. Lauffenburger A simple model for the effects of receptor-mediated cell—substratum adhesion on cell migration , 1989 .

[110]  ScienceDirect Bulletin of mathematical biology , 1973 .