Crystal structure of 1-benzyl-4-(4-chlorophenyl)-2-imino-1,2,5,6,7,8,9,10-octahydrocycloocta[b]pyridine-3-carbonitrile

The title compound comprises a 2-iminopyridine ring fused with a cyclooctane ring, which adopts a twist boat–chair conformation. Intermolecular C—H⋯N interactions form (14) ring motifs and molecules are further connected by weak C—H⋯π interactions.

[1]  R. Vishnupriya,et al.  4-(2-Fluorophenyl)-2-methoxy-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonitrile , 2014, Acta crystallographica. Section E, Structure reports online.

[2]  R. Vishnupriya,et al.  2-Methoxy-4-(2-methoxyphenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine-3-carbonitrile , 2014, Acta crystallographica. Section E, Structure reports online.

[3]  P. Carrupt,et al.  Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity. , 2013, Journal of medicinal chemistry.

[4]  G. El‐Hiti,et al.  Synthesis, antimicrobial and anticancer activities of a novel series of diphenyl 1-(pyridin-3-yl)ethylphosphonates. , 2012, Bioorganic & medicinal chemistry.

[5]  Anthony L. Spek,et al.  Structure validation in chemical crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[6]  S. Rogelj,et al.  Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones. , 2008, Journal of medicinal chemistry.

[7]  G. Sheldrick.  A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[8]  K. B. Wiberg.  The C7-C10 cycloalkanes revisited. , 2003, The Journal of organic chemistry.

[9]  M. Peel,et al.  Pyrazolo[1,5-a]pyridines: synthetic approaches to a novel class of antiherpetics , 2003 .

[10]  T. Aboul-Fadl,et al.  Synthesis, antitubercular activity and pharmacokinetic studies of some schiff bases derived from 1- alkylisatin and isonicotinic acid hydrazide (inh) , 2003, Archives of pharmacal research.

[11]  F. Rinaldi,et al.  Environmentally Friendly Solvent-Free Processes: Novel Dual Catalyst System in Henry Reaction , 2003 .

[12]  A. Abadi,et al.  3-cyano-4,6-disubstituted-2(1H)-imino or oxopyridines : New antineoplastic agents with high selectivity towards leukemia cell lines , 1998 .

[13]  A. Lauria,et al.  Pyrrolo[2,3-d][1,2,3]triazoles as Potential Antineoplastic Agents , 1998 .

[14]  Raymond E. Davis,et al.  Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals , 1995 .

[15]  Donald R. Larkin.  The role of catalysts in the air oxidation of aliphatic aldehydes , 1990 .

[16]  P. D. Cook,et al.  Synthesis and antitumor activity of fluorine-substituted 4-amino-2(1H)-pyridinones and their nucleosides. 3-Deazacytosines. , 1987, Journal of medicinal chemistry.