Linear systems analysis in pharmacokinetics

The application of certain aspects of linear systems analysis to pharmacokinetic-problems is described. Topics covered include the evaluation of in vivodissolution rates, absorption rates, and metabolic rates, and the use of pharmacological data. Relevant numerical procedures are also discussed.

[1]  John L. Stephenson,et al.  Theory of transport in linear biological systems: II. Multiflux problems , 1960 .

[2]  John L. Stephenson,et al.  Theory of transport in linear biological systems: I. Fundamental integral equation , 1960 .

[3]  B. M. Brown.  The mathematical theory of linear systems , 1962 .

[4]  J. Holtzman,et al.  Drug and Tracer Kinetics , 1967 .

[5]  John G. Wagner,et al.  Biopharmaceutics and Relevant Pharmacokinetics , 1971 .

[6]  L. Benet,et al.  General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. , 1972, Journal of pharmaceutical sciences.

[7]  W. F. Rousseau,et al.  Pitfalls in Digital Computation of the Impulse Response of Vascular Beds from Indicator‐Dilution Curves , 1973, Circulation research.

[8]  John G. Wagner,et al.  Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics , 1973, Journal of Pharmacokinetics and Biopharmaceutics.

[9]  John G. Wagner,et al.  Do you need a pharmacokinetic model, and, if so, which one? , 1975, Journal of Pharmacokinetics and Biopharmaceutics.

[10]  V. F. Smolen.  Theoretical and computational basis for drug bioavailability determinations using pharmacological data. I. General considerations and procedures , 1976, Journal of Pharmacokinetics and Biopharmaceutics.

[11]  Addendum 1. Use of isotopes in bioavailability testing , 1973, Journal of Pharmacokinetics and Biopharmaceutics.

[12]  V. F. Smolen.  Theoretical and computational basis for drug bioavailability determinations using pharmacological data. II. Drug input ⇄ response relationships , 1976, Journal of Pharmacokinetics and Biopharmaceutics.

[13]  D. Cutler,et al.  Numerical deconvolution by least squares: Use of prescribed input functions , 1978, Journal of Pharmacokinetics and Biopharmaceutics.

[14]  Numerical deconvolution by least squares: Use of polynomials to represent the input function , 1978, Journal of Pharmacokinetics and Biopharmaceutics.