The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone

[1]  N. Volkow,et al.  Naloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain , 2022, Scientific Reports.

[2]  Matthew R. Irwin,et al.  RAPID FLUCTUATIONS IN BRAIN OXYGENATION DURING GLUCOSE-DRINKING BEHAVIOR IN TRAINED RATS , 2022, Journal of Neurophysiology.

[3]  A. Grossfield,et al.  Nitrosyl factors play a vital role in the ventilatory depressant effects of fentanyl in unanesthetized rats. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[4]  P. Skolnick.  Treatment of overdose in the synthetic opioid era. , 2021, Pharmacology & therapeutics.

[5]  P. Beardsley,et al.  Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated. , 2021, Biochemical pharmacology.

[6]  E. Kiyatkin.  Functional role of peripheral vasoconstriction: not only thermoregulation but much more. , 2021, Journal of integrative neuroscience.

[7]  E. Kiyatkin,et al.  Effects of alcohol on brain oxygenation and brain hypoxia induced by intravenous heroin , 2021, Neuropharmacology.

[8]  E. Kiyatkin,et al.  Relationships between oxygen changes in the brain and periphery following physiological activation and the actions of heroin and cocaine , 2021, Scientific reports.

[9]  Joseph F. Cotten,et al.  D-Amphetamine Accelerates Recovery of Consciousness and Respiratory Drive After High-Dose Fentanyl in Rats , 2020, Frontiers in Pharmacology.

[10]  E. Kiyatkin,et al.  The Role of Peripheral Opioid Receptors in Triggering Heroin-induced Brain Hypoxia , 2020, Scientific Reports.

[11]  D. Bailey.  Oxygen and brain death; back from the brink , 2019, Experimental physiology.

[12]  E. Kiyatkin,et al.  Interactions of benzodiazepines with heroin: Respiratory depression, temperature effects, and behavior , 2019, Neuropharmacology.

[13]  E. Kiyatkin.  PHYSIOLOGICAL AND DRUG-INDUCED FLUCTUATIONS IN BRAIN OXYGEN AND GLUCOSE ASSESSED BY SUBSTRATESELECTIVE SENSORS COUPLED WITH HIGH-SPEED AMPEROMETRY , 2019, Compendium of In Vivo Monitoring in Real-Time Molecular Neuroscience.

[14]  W. Dewey,et al.  Fentanyl depression of respiration: comparison with heroin and morphine , 2019, bioRxiv.

[15]  R. Moss,et al.  Higher doses of naloxone are needed in the synthetic opiod era , 2019, Substance Abuse Treatment, Prevention, and Policy.

[16]  P. Skolnick.  On the front lines of the opioid epidemic: Rescue by naloxone. , 2018, European journal of pharmacology.

[17]  Y. Shaham,et al.  Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature , 2018, Neuropsychopharmacology.

[18]  E. Kiyatkin,et al.  Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia , 2017, eNeuro.

[19]  Y. Shaham,et al.  Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response , 2017, eNeuro.

[20]  E. Kiyatkin,et al.  Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation , 2017, Front. Integr. Neurosci..

[21]  Grant T Baldwin,et al.  Relationship between Nonmedical Prescription-Opioid Use and Heroin Use. , 2016, The New England journal of medicine.

[22]  Meghan MacKenzie,et al.  Opioid Pharmacokinetics-Pharmacodynamics , 2016, The Annals of pharmacotherapy.

[23]  W. Meutermans,et al.  In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile , 2015, British journal of pharmacology.

[24]  J. Duffin,et al.  Respiratory, cerebrovascular and cardiovascular responses to isocapnic hypoxia , 2011, Respiratory Physiology & Neurobiology.

[25]  Donna J. Calu,et al.  Opiate versus psychostimulant addiction: the differences do matter , 2011, Nature Reviews Neuroscience.

[26]  D. Attwell,et al.  Glial and neuronal control of brain blood flow , 2022 .

[27]  E. Bruera,et al.  New opioids: expensive distractions or important additions to practice? , 2010, Journal of palliative medicine.

[28]  Jun Ren,et al.  Ampakine CX717 Protects against Fentanyl-induced Respiratory Depression and Lethal Apnea in Rats , 2009, Anesthesiology.

[29]  K. Pattinson,et al.  Opioids and the control of respiration. , 2008, British journal of anaesthesia.

[30]  M. Danhof,et al.  Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats. , 2005, British journal of anaesthesia.

[31]  A. Laferriere,et al.  Ontogeny of respiratory sensitivity and tolerance to the mu-opioid agonist fentanyl in rat. , 2005, Brain research. Developmental brain research.

[32]  A. Sandler,et al.  A review of the use of fentanyl analgesia in the management of acute pain in adults. , 1999, Anesthesiology.

[33]  M. Yeadon,et al.  Opioids and respiration , 1989, Progress in Neurobiology.

[34]  R. Wise,et al.  A psychomotor stimulant theory of addiction. , 1987, Psychological review.

[35]  C. Hug,et al.  Tissue Redistribution of Fentanyl and Termination of Its Effects in Rats , 1981, Anesthesiology.

[36]  B. Pleuvry,et al.  Antagonism of the respiratory effects of alfentanil and fentanyl by naloxone in the conscious rabbit. , 1981, British journal of anaesthesia.

[37]  Douglas L. Jones,et al.  From motivation to action: Functional interface between the limbic system and the motor system , 1980, Progress in Neurobiology.

[38]  C. Niemegeers,et al.  Synthetic analgesics. Synthesis and pharmacology of the diastereoisomers of N-(3-methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide and N-(3-methyl-1-(1-methyl-2-phenylethyl)-4-piperidyl)-N-phenylpropanamide. , 1974, Journal of medicinal chemistry.

[39]  Rachael Rzasa Lynn,et al.  Naloxone dosage for opioid reversal: current evidence and clinical implications , 2018, Therapeutic advances in drug safety.

[40]  Kathleen Mclaughlin.  Deadly chemistry. , 2017, Science.

[41]  G. Koob,et al.  Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access , 2015, Neuropsychopharmacology.

[42]  Katharina M. Busl,et al.  Hypoxic-ischemic brain injury: pathophysiology, neuropathology and mechanisms. , 2010, NeuroRehabilitation.

[43]  S. Kety,et al.  Recent studies of cerebral blood flow and cerebral metabolism in man. , 1947, Transactions of the Association of American Physicians.