Developing injectable nanomaterials to repair the heart.

Injectable nanomaterials have been designed for the treatment of myocardial infarction, particularly during the acute stages of inflammation and injury. Among these strategies, injectable nanofibrous hydrogel networks or nanoparticle complexes may be delivered alone or with a therapeutic to improve heart function. Intramyocardial delivery of these materials localizes treatments to the site of injury. As an alternative, nanoparticles may be delivered intravenously, which provides the ultimate minimally invasive approach. These systems take advantage of the leaky vasculature after myocardial infarction, and may be designed to specifically target the injured region. The translational applicability of both intramyocardial and intravenous applications may provide safe and effective solutions upon optimizing the timing of the treatments and biodistribution.

[1]  N. Sharpe,et al.  Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. , 2000, Circulation.

[2]  K. Christman,et al.  Concise Review: Injectable Biomaterials for the Treatment of Myocardial Infarction and Peripheral Artery Disease: Translational Challenges and Progress , 2014, Stem cells translational medicine.

[3]  Stephane Heymans,et al.  Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window. , 2006, Cardiovascular research.

[4]  Richard T. Lee,et al.  Identification of targeting peptides for ischemic myocardium by in vivo phage display. , 2011, Journal of molecular and cellular cardiology.

[5]  Parkson Lee-Gau Chong,et al.  Targeting VEGF‐encapsulated immunoliposomes to MI heart improves vascularity and cardiac function , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  Geunbae Lim,et al.  Ion concentration polarization-based continuous separation device using electrical repulsion in the depletion region , 2013, Scientific Reports.

[7]  Mark D. Huffman,et al.  Heart disease and stroke statistics--2013 update: a report from the American Heart Association. , 2013, Circulation.

[8]  C Shad Thaxton,et al.  Nanoparticle therapeutics: FDA approval, clinical trials, regulatory pathways, and case study. , 2011, Methods in molecular biology.

[9]  Jeffrey H. Omens,et al.  Increased Infarct Wall Thickness by a Bio-Inert Material Is Insufficient to Prevent Negative Left Ventricular Remodeling after Myocardial Infarction , 2011, PloS one.

[10]  J. Piek,et al.  Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response , 2012, Heart.

[11]  Richard T. Lee,et al.  Injectable Self-Assembling Peptide Nanofibers Create Intramyocardial Microenvironments for Endothelial Cells , 2005, Circulation.

[12]  S. Seif-Naraghi,et al.  Injectable extracellular matrix derived hydrogel provides a platform for enhanced retention and delivery of a heparin-binding growth factor. , 2012, Acta Biomaterialia.

[13]  M. Entman,et al.  The inflammatory response in myocardial infarction. , 2002, Cardiovascular research.

[14]  A. Khademhosseini,et al.  Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair , 2014, ACS nano.

[15]  J. Burdick,et al.  Injectable Acellular Hydrogels for Cardiac Repair , 2011, Journal of cardiovascular translational research.

[16]  K. Christman,et al.  Biomaterials for the treatment of myocardial infarction: a 5-year update. , 2011, Journal of the American College of Cardiology.

[17]  Raymond M. Wang,et al.  Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction. , 2015, Biomaterials.

[18]  Jay C. Sy,et al.  Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA. , 2010, Organic letters.

[19]  S. Germain,et al.  Protection against Myocardial Infarction and No-reflow through Preservation of Vascular Integrity by Angiopoietin-like 4 Running Title: Galaup Et Al.; Protecting Vascular Integrity in Heart Ischemia , 2022 .

[20]  Jennifer M. Singelyn,et al.  Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. , 2009, Biomaterials.

[21]  James J. Lai,et al.  Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[22]  E. W. Meijer,et al.  A Fast pH‐Switchable and Self‐Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium , 2014, Advanced healthcare materials.

[23]  J. Leor,et al.  Intracoronary Delivery of Injectable Bioabsorbable Scaffold (IK-5001) to Treat Left Ventricular Remodeling After ST-Elevation Myocardial Infarction: A First-in-Man Study , 2014, Circulation. Cardiovascular interventions.

[24]  A. DeMaria,et al.  Safety and Efficacy of an Injectable Extracellular Matrix Hydrogel for Treating Myocardial Infarction , 2013, Science Translational Medicine.

[25]  J. Strom,et al.  Nanoparticle oxygen delivery to the ischemic heart , 2014, Perfusion.

[26]  Smadar Cohen,et al.  Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. , 2009, Journal of the American College of Cardiology.

[27]  A. DeMaria,et al.  Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. , 2012, Journal of the American College of Cardiology.

[28]  Yi-Dong Lin,et al.  A nanopatterned cell-seeded cardiac patch prevents electro-uncoupling and improves the therapeutic efficacy of cardiac repair. , 2014, Biomaterials science.

[29]  N. Frangogiannis,et al.  The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. , 2010, Journal of molecular and cellular cardiology.

[30]  Randall J Lee,et al.  Biomaterials for the treatment of myocardial infarction. , 2006, Journal of the American College of Cardiology.

[31]  Hai-dong Guo,et al.  Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction. , 2012, Biochemical and biophysical research communications.

[32]  Richard T. Lee,et al.  Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Eric Pridgen,et al.  Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles , 2008, Molecular pharmaceutics.

[34]  W. Hartner,et al.  Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti-myosin antibody and TAT peptide , 2009, Gene Therapy.

[35]  S. Ramakrishna,et al.  Biologically improved nanofibrous scaffolds for cardiac tissue engineering. , 2014, Materials science & engineering. C, Materials for biological applications.

[36]  K. Nicolay,et al.  Distribution of lipid-based nanoparticles to infarcted myocardium with potential application for MRI-monitored drug delivery. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[37]  Ali Khademhosseini,et al.  PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues. , 2013, Biomaterials.

[38]  Tal Dvir,et al.  Nanoparticles targeting the infarcted heart. , 2011, Nano letters.

[39]  J. Gorman,et al.  Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[40]  S. Ramakrishna,et al.  Xylan polysaccharides fabricated into nanofibrous substrate for myocardial infarction. , 2013, Materials science & engineering. C, Materials for biological applications.

[41]  Jay C. Sy,et al.  Targeting Extracellular DNA to Deliver IGF-1 to the Injured Heart , 2013, Scientific Reports.

[42]  Hua-Lin Wu,et al.  Intramyocardial Peptide Nanofiber Injection Improves Postinfarction Ventricular Remodeling and Efficacy of Bone Marrow Cell Therapy in Pigs , 2010, Circulation.

[43]  William R Wagner,et al.  Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges. , 2011, Acta biomaterialia.

[44]  S. W. Kim,et al.  Targeted gene delivery to ischemic myocardium by homing peptide-guided polymeric carrier. , 2013, Molecular pharmaceutics.

[45]  Yi-Dong Lin,et al.  Instructive Nanofiber Scaffolds with VEGF Create a Microenvironment for Arteriogenesis and Cardiac Repair , 2012, Science Translational Medicine.

[46]  K. Christman,et al.  Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction , 2013, Expert opinion on drug delivery.