LONG‐TERM RESULTS OF GASTRIC CANCER SCREENING USING THE SERUM PEPSINOGEN TEST METHOD AMONG AN ASYMPTOMATIC MIDDLE‐AGED JAPANESE POPULATION

Background and Aim:  In order to reduce gastric cancer death, mass screening for gastric cancer has been established in Japan for several decades. Only photofluorography is considered to be an acceptable screening method so far, but recent evidence may show the usefulness of serum pepsinogen (PG) measurement for gastric cancer screening. The aim of the present study was to elucidate the feasibility of measuring serum PG levels for detection of gastric cancers.

[1]  Khean Lee Goh,et al.  Screening for gastric cancer in Asia: current evidence and practice. , 2008, The Lancet. Oncology.

[2]  N. Ananthakrishnan,et al.  Serum pepsinogen I and II levels in various gastric disorders with special reference to their use as a screening test for carcinoma stomach. , 2007, Tropical gastroenterology : official journal of the Digestive Diseases Foundation.

[3]  S. Xiao,et al.  Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin‐17 and Helicobacter pylori immunoglobulin G antibodies , 2007, Journal of digestive diseases.

[4]  K. Miki,et al.  Using serum pepsinogens wisely in a clinical practice , 2007, Journal of digestive diseases.

[5]  K. Haruma,et al.  Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: A case-control study , 2007, Scandinavian journal of gastroenterology.

[6]  Martin J Blaser,et al.  Infection, cancer and prevention: report of the 19th International Symposium of the Foundation for Promotion of Cancer Research. , 2006, Japanese journal of clinical oncology.

[7]  M. Inoue,et al.  Effect of Helicobacter pylori Infection Combined with CagA and Pepsinogen Status on Gastric Cancer Development among Japanese Men and Women: A Nested Case-Control Study , 2006, Cancer Epidemiology Biomarkers & Prevention.

[8]  M. Kubo,et al.  The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study. , 2006, American journal of epidemiology.

[9]  K. Miki.  Gastric cancer screening using the serum pepsinogen test method , 2002, Gastric Cancer.

[10]  N. Yoshimura,et al.  Gastric cancer screening of a high‐risk population in Japan using serum pepsinogen and barium digital radiography , 2005, Cancer science.

[11]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[12]  A. Costa-Pereira,et al.  Meta-analysis on the validity of pepsinogen test for gastric carcinoma, dysplasia or chronic atrophic gastritis screening , 2004, Journal of medical screening.

[13]  K. Miki,et al.  Usefulness of Gastric Cancer Screening Using the Serum Pepsinogen Test Method , 2003, American Journal of Gastroenterology.

[14]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[15]  I. Tsuji,et al.  The evaluation of screening for gastric cancer in miyagi prefecture, Japan: A population‐based case‐control study , 1995, International journal of cancer.

[16]  M. Matsushima,et al.  The clinical application of the serum pepsinogen I and II levels as a mass screening method for gastric cancer. , 1995, Advances in experimental medicine and biology.

[17]  Kenji Takahashi,et al.  The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects , 1989, Japanese journal of cancer research : Gann.