Effectiveness of robotics in improving upper extremity functions among people with neurological dysfunction: a systematic review

Abstract Purpose: The primary focus of this review was to find out the effectiveness of robotics in improving upper extremity functions among people with neurological problems in the arena of physical rehabilitation. Material and methods: Two reviewers independently scrutinized the included studies. The selected studies underwent quality assessment by Physiotherapy Evidence Database (PEDro) scale. Randomized Controlled Trial (RCT) having a score of four or more were included in the review. A search was conducted in PUBMED, MEDLINE, CINAHL, EMBASE, PROQUEST, science direct, Cochrane Library, PEDro and Google Scholar. Results: A total of 202 studies were identified. After removal of duplication, inclusion and exclusion criteria’s n = 23 studies were included in the review process. For analysis, only the primary outcome measures of the studies were taken into account. Studies finally included in analysis were n = 21. The included studies were 19 in stroke, 1 in cerebral palsy (CP) and 1 study in multiple sclerosis (MS). No RCTs were reportedly found in spinal cord injury (SCI), Parkinson and motor neuron disease (MND). Conclusions: Studies related to stroke showed a clear definiteness in the improvement of upper extremity functions. On the contrary, there still remains a need for quality trials in CP, MS to establish the efficacy of robotics in upper extremity rehabilitation.

[1]  Luis Enrique Sucar,et al.  Robot training for hand motor recovery in subacute stroke patients: A randomized controlled trial. , 2016, Journal of hand therapy : official journal of the American Society of Hand Therapists.

[2]  A. Rhoda,et al.  Activity limitations and factors influencing functional outcome of patients with stroke following rehabilitation at a specialised facility in the Western Cape. , 2013, African health sciences.

[3]  S. De Geest,et al.  Adherence to Long-Term Therapies: Evidence for Action , 2003, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[4]  S. Satya‐Murti Evidence-based Medicine: How to Practice and Teach EBM , 1997 .

[5]  J. Daly,et al.  Comparison of robotics, functional electrical stimulation, and motor learning methods for treatment of persistent upper extremity dysfunction after stroke: a randomized controlled trial. , 2015, Archives of physical medicine and rehabilitation.

[6]  K. Anderson Targeting recovery: priorities of the spinal cord-injured population. , 2004, Journal of neurotrauma.

[7]  John J. Foxe,et al.  Patterns of normal human brain plasticity after practice and their implications for neurorehabilitation. , 2006, Archives of physical medicine and rehabilitation.

[8]  R. Teasell,et al.  Estimates of quality and reliability with the physiotherapy evidence-based database scale to assess the methodology of randomized controlled trials of pharmacological and nonpharmacological interventions. , 2006, Physical therapy.

[9]  Michael Swash, Joy Desai Motor neuron disease: Classification and nomenclature , 2000, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

[10]  C. Burgar,et al.  MIME robotic device for upper-limb neurorehabilitation in subacute stroke subjects: A follow-up study. , 2006, Journal of rehabilitation research and development.

[11]  A. Kottink,et al.  The Effect of Arm Support Combined With Rehabilitation Games on Upper-Extremity Function in Subacute Stroke , 2015, Neurorehabilitation and neural repair.

[12]  Stefano Tamburin,et al.  Robot-assisted arm training in patients with Parkinson’s disease: a pilot study , 2014, Journal of NeuroEngineering and Rehabilitation.

[13]  Ching-yi Wu,et al.  Effect of Therapist-Based Versus Robot-Assisted Bilateral Arm Training on Motor Control, Functional Performance, and Quality of Life After Chronic Stroke: A Clinical Trial , 2012, Physical Therapy.

[14]  S. Masiero,et al.  Robotic-assisted rehabilitation of the upper limb after acute stroke. , 2007, Archives of physical medicine and rehabilitation.

[15]  Grant D. Huang,et al.  Robot-assisted therapy for long-term upper-limb impairment after stroke. , 2010, The New England journal of medicine.

[16]  E. Roth,et al.  Physical Activity and Exercise Recommendations for Stroke Survivors: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2014, Stroke.

[17]  S. Masiero,et al.  Randomized Trial of a Robotic Assistive Device for the Upper Extremity During Early Inpatient Stroke Rehabilitation , 2014, Neurorehabilitation and neural repair.

[18]  Bruno Dehez,et al.  Upper Limb Robot-Assisted Therapy in Cerebral Palsy , 2015, Neurorehabilitation and neural repair.

[19]  Diego Torricelli,et al.  Hybrid robotic systems for upper limb rehabilitation after stroke: A review. , 2016, Medical engineering & physics.

[20]  M. Johnson,et al.  Technology-assisted stroke rehabilitation in Mexico: a pilot randomized trial comparing traditional therapy to circuit training in a Robot/technology-assisted therapy gym , 2016, Journal of NeuroEngineering and Rehabilitation.

[21]  C. M. C. Costa,et al.  Application of International Classification of Functioning, Disability and Health (ICF) in individuals with spinal cord injury. , 2011, Arquivos de neuro-psiquiatria.

[22]  N. Hogan,et al.  Response to upper-limb robotics and functional neuromuscular stimulation following stroke. , 2005, Journal of rehabilitation research and development.

[23]  M. Aisen,et al.  Cerebral palsy: clinical care and neurological rehabilitation , 2011, The Lancet Neurology.

[24]  J. Mehrholz,et al.  Computerized Arm Training Improves the Motor Control of the Severely Affected Arm After Stroke: A Single-Blinded Randomized Trial in Two Centers , 2005, Stroke.

[25]  A. Mutlu,et al.  Impairments, activity limitations, and participation restrictions of the international classification of functioning, disability, and health model in children with ambulatory cerebral palsy , 2017, Saudi medical journal.

[26]  Sharon E Straus,et al.  Evidence-Based Medicine: How to Practice and Teach It , 2010 .

[27]  C. Wolfe,et al.  Prevalence of Poststroke Cognitive Impairment: South London Stroke Register 1995–2010 , 2013, Stroke.

[28]  Ashutosh Kumar Singh,et al.  Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 , 2016, The Lancet.

[29]  R. Akinyemi,et al.  Stroke Investigative Research and Education Network , 2016, Health education & behavior : the official publication of the Society for Public Health Education.

[30]  N. Hogan,et al.  A novel approach to stroke rehabilitation , 2000, Neurology.

[31]  I J Higginson,et al.  Using quality of life measures in the clinical setting , 2001, BMJ : British Medical Journal.

[32]  D. Karussis,et al.  The Frequency of Multiple Sclerosis in Jewish and Arab Populations in Greater Jerusalem , 2003, Neuroepidemiology.

[33]  W. Rymer,et al.  Robot-assisted reaching exercise promotes arm movement recovery in chronic hemiparetic stroke: a randomized controlled pilot study , 2006, Journal of NeuroEngineering and Rehabilitation.

[34]  K. Coninx,et al.  Robot-supported upper limb training in a virtual learning environment : a pilot randomized controlled trial in persons with MS , 2015, Journal of NeuroEngineering and Rehabilitation.

[35]  C. Burgar,et al.  Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke. , 2002, Archives of physical medicine and rehabilitation.

[36]  G. Fazekas,et al.  Robot-mediated upper limb physiotherapy for patients with spastic hemiparesis: a preliminary study. , 2007, Journal of rehabilitation medicine.

[37]  K. Torén,et al.  Twenty-Four-Year Trends in the Incidence of Ischemic Stroke in Sweden From 1987 to 2010 , 2013, Stroke.

[38]  S. Wolf,et al.  Quality-of-Life Change Associated With Robotic-Assisted Therapy to Improve Hand Motor Function in Patients With Subacute Stroke: A Randomized Clinical Trial , 2010, Physical Therapy.

[39]  D. Lynch,et al.  A pilot study of activity-based therapy in the arm motor recovery post stroke: a randomized controlled trial , 2008, Clinical rehabilitation.

[40]  I. Schwartz,et al.  Robot-assisted gait training in multiple sclerosis patients: a randomized trial , 2012, Multiple sclerosis.

[41]  Sarah J. Housman,et al.  A Randomized Controlled Trial of Gravity-Supported, Computer-Enhanced Arm Exercise for Individuals With Severe Hemiparesis , 2009, Neurorehabilitation and neural repair.

[42]  R. Calabró,et al.  Effects of robot-assisted upper limb rehabilitation in stroke patients: a systematic review with meta-analysis , 2017, Neurological Sciences.

[43]  K. Domen,et al.  Efficacy of Upper Extremity Robotic Therapy in Subacute Poststroke Hemiplegia: An Exploratory Randomized Trial , 2016, Stroke.

[44]  Corina Schuster-Amft,et al.  Cardiopulmonary exercise testing early after stroke using feedback-controlled robotics-assisted treadmill exercise: test-retest reliability and repeatability , 2014, Journal of NeuroEngineering and Rehabilitation.

[45]  Stefan Hesse,et al.  Effect on arm function and cost of robot-assisted group therapy in subacute patients with stroke and a moderately to severely affected arm: a randomized controlled trial , 2014, Clinical rehabilitation.

[46]  Won Hyuk Chang,et al.  Robot-assisted Therapy in Stroke Rehabilitation , 2013, Journal of stroke.

[47]  H. Krebs,et al.  Effects of Robot-Assisted Therapy on Upper Limb Recovery After Stroke: A Systematic Review , 2008, Neurorehabilitation and neural repair.