Sublingual tacrolimus administration provides similar drug exposure to per‐oral route employing lower doses in liver transplantation: a pilot study

Per‐oral tacrolimus administration is not always practicable. Sublingual administration is a potential alternative, but its feasibility and effectiveness compared with oral route has not been established.

[1]  J. Meulenbelt,et al.  Pharmacokinetics and Toxicity of Tacrolimus Early After Heart and Lung Transplantation , 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[2]  Jeong M. Park,et al.  Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients. , 2015, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[3]  M. Christiaans,et al.  Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers. , 2014, British journal of clinical pharmacology.

[4]  A. Shaked,et al.  Immunosuppression: trends and tolerance? , 2014, Clinics in liver disease.

[5]  G. Snell,et al.  Evolution to twice daily bolus intravenous tacrolimus: optimizing efficacy and safety of calcineurin inhibitor delivery early post lung transplant. , 2013, Annals of transplantation.

[6]  S. Cremers,et al.  Sublingual Tacrolimus: A Pharmacokinetic Evaluation Pilot Study , 2013, Pharmacotherapy.

[7]  A. Abdollahi,et al.  Clinical pharmacokinetics of oral versus sublingual administration of tacrolimus in adult liver transplant recipients. , 2012, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.

[8]  R. Guillemain,et al.  Sublingual tacrolimus as an alternative to intravenous route in patients with thoracic transplant: a retrospective study. , 2010, Transplantation Proceedings.

[9]  J. Hooff,et al.  A PILOT STUDY ON SUBLINGUAL AND RECTAL ADMINISTRATION OF TACROLIMUS: 1219 , 2008 .

[10]  A. Borobia,et al.  Sublingual administration of tacrolimus in a renal transplant patient , 2008, Journal of clinical pharmacy and therapeutics.

[11]  K. Patel,et al.  Buccal Mucosa as A Route for Systemic Drug Delivery: A Review , 2012 .

[12]  Xiaoling Li,et al.  Sublingual drug delivery. , 2008, Critical reviews in therapeutic drug carrier systems.

[13]  K. Iwasaki.  Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. , 2007, Drug metabolism and pharmacokinetics.

[14]  C. Staatz,et al.  Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation , 2004, Clinical pharmacokinetics.