Indole RSK inhibitors. Part 1: discovery and initial SAR.
暂无分享,去创建一个
J. Madwed | M. Kashem | R. Snow | J. Westbrook | F. Dicapua | A. Swinamer | A. Padyana | Zhaoming Xiong | M. M. O'Neill | T. Kirrane | Christopher Sarko | D. Cogan | S. Boyer | S. Kugler | Yunlong Zhang | Xin Guo | J. Burke | Amy Gao | Lida Soleymanzadeh
[1] S. Goueli,et al. ADP-Glo: A Bioluminescent and homogeneous ADP monitoring assay for kinases. , 2009, Assay and drug development technologies.
[2] K. Parris,et al. Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). , 2009, Bioorganic & medicinal chemistry.
[3] Yuji Arai,et al. Activation of Na (cid:1) /H (cid:1) Exchanger 1 Is Sufficient to Generate Ca 2 (cid:1) Signals That Induce Cardiac Hypertrophy and Heart Failure , 2022 .
[4] J. Blenis,et al. The RSK family of kinases: emerging roles in cellular signalling , 2008, Nature Reviews Molecular Cell Biology.
[5] T. Nguyen. Targeting RSK: an overview of small molecule inhibitors. , 2008, Anti-cancer agents in medicinal chemistry.
[6] C. Somps,et al. Na+/H+ exchanger-1 inhibitors reduce neuronal excitability and alter na+ channel inactivation properties in rat primary sensory neurons. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.
[7] J. Arezzo,et al. Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na+/H+ Exchanger Isoform 1 , 2008, Toxicologic pathology.
[8] J. Blenis,et al. The RSK factors of activating the Ras/MAPK signaling cascade. , 2008, Frontiers in bioscience : a journal and virtual library.
[9] S. Javadov,et al. The role of NHE-1 in myocardial hypertrophy and remodelling. , 2008, Journal of molecular and cellular cardiology.
[10] G. Buckberg,et al. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. , 2008, The Annals of thoracic surgery.
[11] M. Avkiran,et al. Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach? , 2008, Current opinion in pharmacology.
[12] M. Hao,et al. Synthesis and SAR studies of indole-based MK2 inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[13] M. Hao,et al. Pyrazinoindolone inhibitors of MAPKAP-K2. , 2008, Bioorganic & medicinal chemistry letters.
[14] S. Munshi,et al. Crystal structures of the N‐terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors , 2007, Protein science : a publication of the Protein Society.
[15] Michel Emmanuel,et al. The discovery of carboline analogs as potent MAPKAP-K2 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.
[16] S. Semus,et al. Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity. , 2007, Journal of medicinal chemistry.
[17] J. Abe,et al. Inhibiting p90 Ribosomal S6 Kinase Prevents Na+-H+ Exchanger–Mediated Cardiac Ischemia-Reperfusion Injury , 2006, Circulation.
[18] M. Karmazyn,et al. The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention. , 2005, Current drug targets. Cardiovascular & haematological disorders.
[19] M. Avkiran,et al. Effects of bisindolylmaleimide PKC inhibitors on p90RSK activity in vitro and in adult ventricular myocytes , 2005, British journal of pharmacology.
[20] J. Silber,et al. Functional Characterization of Human RSK4, a New 90-kDa Ribosomal S6 Kinase, Reveals Constitutive Activation in Most Cell Types* , 2005, Journal of Biological Chemistry.
[21] M. Karmazyn,et al. Activation of Na+/H+ Exchanger-directed Protein Kinases in the Ischemic and Ischemic-reperfused Rat Myocardium* , 2001, The Journal of Biological Chemistry.
[22] M. Karmazyn,et al. The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease. , 1999, Circulation research.
[23] G. Binsch,et al. Ring inversion barrier in 5,5-difluoro-1,3-dioxane , 1973 .
[24] M. Kashem,et al. Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity. , 2012, Bioorganic & medicinal chemistry letters.
[25] Zigang Dong,et al. Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2 , 2008, Nature Structural &Molecular Biology.
[26] J. Greve,et al. Abstracts of papers , 2005, Pharmaceutisch Weekblad.
[27] L. Harwood,et al. The direct synthesis of the cyclic sulphamidate of (S)-prolinol: SimultaneousN-protection and activation towards nucleophilic displacement of oxygen. , 1990 .