Base changes in tumour DNA have the power to reveal the causes and evolution of cancer

[1]  Y. Hannun,et al.  Substantial contribution of extrinsic risk factors to cancer development , 2015, Nature.

[2]  Hanlee P. Ji,et al.  Pan-cancer analysis of the extent and consequences of intratumor heterogeneity , 2015, Nature Medicine.

[3]  M. Stratton,et al.  Clock-like mutational processes in human somatic cells , 2015, Nature Genetics.

[4]  J. Chu,et al.  Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans , 2015, G3: Genes, Genomes, Genetics.

[5]  Steven A. Roberts,et al.  APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. , 2015, Cell reports.

[6]  Christopher P. Wild,et al.  Genomics of Cancer and a New Era for Cancer Prevention , 2015, PLoS genetics.

[7]  Serena Nik-Zainal,et al.  A mutational signature in gastric cancer suggests therapeutic strategies , 2015, Nature Communications.

[8]  M. Stratton,et al.  The genome as a record of environmental exposure , 2015, Mutagenesis.

[9]  X. Castells,et al.  Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[10]  Gad Getz,et al.  An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers , 2015, Nature Genetics.

[11]  Samuel H. Wilson,et al.  Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer , 2015, Proceedings of the National Academy of Sciences.

[12]  Peter C. Stirling,et al.  Dissecting genetic and environmental mutation signatures with model organisms. , 2015, Trends in genetics : TIG.

[13]  D. Lambrechts,et al.  Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma , 2015, Nature Medicine.

[14]  S. Tavaré,et al.  Whole-genome sequencing provides new insights into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma , 2015, Nature Genetics.

[15]  X. Castells,et al.  Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid , 2015, International journal of cancer.

[16]  J. Vijg,et al.  High-throughput sequencing in mutation detection: A new generation of genotoxicity tests? , 2015, Mutation research.

[17]  M. Stephens,et al.  A Simple Model-Based Approach to Inferring and Visualizing Cancer Mutation Signatures , 2015, bioRxiv.

[18]  M. Stratton,et al.  High burden and pervasive positive selection of somatic mutations in normal human skin , 2015, Science.

[19]  Bin Tean Teh,et al.  Mutation signatures implicate aristolochic acid in bladder cancer development , 2015, Genome Medicine.

[20]  Michael Huemer,et al.  AID/APOBEC deaminases and cancer , 2015, Oncoscience.

[21]  Huanming Yang,et al.  Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma , 2015, American journal of human genetics.

[22]  Jessica Zucman-Rossi,et al.  Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets , 2015, Nature Genetics.

[23]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[24]  Roland Arnold,et al.  Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers , 2015, Nature Genetics.

[25]  B. Vogelstein,et al.  Variation in cancer risk among tissues can be explained by the number of stem cell divisions , 2015, Science.

[26]  G. Pfeifer.  How the environment shapes cancer genomes , 2015, Current opinion in oncology.

[27]  Thomas M. Keane,et al.  The mutational landscapes of genetic and chemical models of Kras-driven lung cancer , 2014, Nature.

[28]  D. Brash.  UV Signature Mutations , 2015, Photochemistry and photobiology.

[29]  Pål Sætrom,et al.  AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature. , 2015, DNA repair.

[30]  K. Hemminki,et al.  Impact of functional germline variants and a deletion polymorphism in APOBEC3A and APOBEC3B on breast cancer risk and survival in a Swedish study population , 2015, Journal of Cancer Research and Clinical Oncology.

[31]  A. Morris,et al.  Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions , 2015, BDJ.

[32]  Nansheng Chen,et al.  Mutational landscape of intrahepatic cholangiocarcinoma , 2014, Nature Communications.

[33]  M. Stampfer,et al.  Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. , 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

[34]  Hiromi Nakamura,et al.  Trans-ancestry mutational landscape of hepatocellular carcinoma genomes , 2014, Nature Genetics.

[35]  M. Santiago,et al.  APOBEC3A Functions as a Restriction Factor of Human Papillomavirus , 2014, Journal of Virology.

[36]  Edgars Celms,et al.  Variation in genomic landscape of clear cell renal cell carcinoma across Europe , 2014, Nature Communications.

[37]  Yu Cao,et al.  Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing , 2014, Science.

[38]  Z. Szallasi,et al.  Spatial and temporal diversity in genomic instability processes defines lung cancer evolution , 2014, Science.

[39]  Serena Nik-Zainal,et al.  Mechanisms underlying mutational signatures in human cancers , 2014, Nature Reviews Genetics.

[40]  Peter J. Campbell,et al.  C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency , 2014, Genome research.

[41]  B. Peters,et al.  Whole-genome sequencing of asian lung cancers: second-hand smoke unlikely to be responsible for higher incidence of lung cancer among Asian never-smokers. , 2014, Cancer research.

[42]  S. Henderson,et al.  APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development. , 2014, Cell reports.

[43]  Rebecca C Fitzgerald,et al.  Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis , 2014, Nature Genetics.

[44]  Anne-Mette K. Hein,et al.  Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue , 2014, PloS one.

[45]  R. Gibbs,et al.  Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers , 2014, Clinical Cancer Research.

[46]  Adam P Butler,et al.  Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer , 2014, Nature Genetics.

[47]  X. Castells,et al.  Modelling mutational landscapes of human cancers in vitro , 2014, Scientific Reports.

[48]  Steven A Roberts,et al.  Clustered and genome‐wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness , 2014, BioEssays : news and reviews in molecular, cellular and developmental biology.

[49]  M. Stratton,et al.  Mutational signatures: the patterns of somatic mutations hidden in cancer genomes , 2014, Current opinion in genetics & development.

[50]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of urothelial bladder carcinoma , 2014, Nature.

[51]  Steven J. M. Jones,et al.  Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma , 2014, Science.

[52]  B. Stewart,et al.  World cancer report 2014. , 2014 .

[53]  The Cancer Genome Atlas Research Network.  Comprehensive molecular characterization of urothelial bladder carcinoma , 2014, Nature.

[54]  N. A. Temiz,et al.  Evidence for APOBEC3B mutagenesis in multiple human cancers , 2013, Nature Genetics.

[55]  David T. W. Jones,et al.  Signatures of mutational processes in human cancer , 2013, Nature.

[56]  P. A. Futreal,et al.  Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool , 2013, Science Translational Medicine.

[57]  K. Kinzler,et al.  Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing , 2013, Science Translational Medicine.

[58]  M. Olivier,et al.  Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid. , 2013, Mutation research.

[59]  P. Campbell,et al.  EMu: probabilistic inference of mutational processes and their localization in the cancer genome , 2013, Genome Biology.

[60]  K. Kinzler,et al.  Cancer Genome Landscapes , 2013, Science.

[61]  E. Lander,et al.  Lessons from the Cancer Genome , 2013, Cell.

[62]  A. McKenna,et al.  Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity , 2013, Nature Genetics.

[63]  N. A. Temiz,et al.  APOBEC3B is an enzymatic source of mutation in breast cancer , 2013, Nature.

[64]  M. Stratton,et al.  Deciphering Signatures of Mutational Processes Operative in Human Cancer , 2013, Cell reports.

[65]  A. Grollman,et al.  Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease , 2013, Environmental and molecular mutagenesis.

[66]  Li Ding,et al.  Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers , 2012, Cell.

[67]  M. Strout,et al.  The role of activation-induced cytidine deaminase in lymphomagenesis , 2012, Current opinion in hematology.

[68]  A. Børresen-Dale,et al.  Mutational Processes Molding the Genomes of 21 Breast Cancers , 2012, Cell.

[69]  HaroldC. Smith,et al.  Functions and regulation of the APOBEC family of proteins. , 2012, Seminars in cell & developmental biology.

[70]  P. A. Futreal,et al.  Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. , 2012, The New England journal of medicine.

[71]  A. McKenna,et al.  The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.

[72]  M. Stratton.  Exploring the Genomes of Cancer Cells: Progress and Promise , 2011, Science.

[73]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[74]  Steven J. M. Jones,et al.  Whole-Genome Profiling of Mutagenesis in Caenorhabditis elegans , 2010, Genetics.

[75]  V. Rotter,et al.  Mutant p53 gain-of-function in cancer. , 2010, Cold Spring Harbor perspectives in biology.

[76]  Magali Olivier,et al.  TP53 mutations in human cancers: origins, consequences, and clinical use. , 2010, Cold Spring Harbor perspectives in biology.

[77]  C. Prives,et al.  Blinded by the Light: The Growing Complexity of p53 , 2009, Cell.

[78]  M. Stratton,et al.  The cancer genome , 2009, Nature.

[79]  Harald zur Hausen,et al.  Papillomaviruses in the causation of human cancers - a brief historical account. , 2009, Virology.

[80]  B. Jelaković,et al.  Aristolochic acid and the etiology of endemic (Balkan) nephropathy , 2007, Proceedings of the National Academy of Sciences.

[81]  E. Birney,et al.  Patterns of somatic mutation in human cancer genomes , 2007, Nature.

[82]  M. Hollstein,et al.  Mutagenesis of human p53 tumor suppressor gene sequences in embryonic fibroblasts of genetically-engineered mice. , 2007, Genetic engineering.

[83]  M. Hollstein,et al.  Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[84]  B. Stewart,et al.  World Cancer Report , 2003 .

[85]  C. Harris,et al.  Radical causes of cancer , 2003, Nature Reviews Cancer.

[86]  Reuben S Harris,et al.  RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. , 2002, Molecular cell.

[87]  N. Tretyakova,et al.  Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers , 2002, Oncogene.

[88]  L. Marnett,et al.  Endogenous DNA damage and mutation. , 2001, Trends in genetics : TIG.

[89]  P. Hainaut,et al.  New approaches to understanding p53 gene tumor mutation spectra. , 1999, Mutation research.

[90]  H. Sebastian Seung,et al.  Learning the parts of objects by non-negative matrix factorization , 1999, Nature.

[91]  P. Hainaut,et al.  Hepatocellular carcinoma: from gene to public health. , 1997, Journal of the National Cancer Institute.

[92]  M. Tang,et al.  Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.

[93]  T. Lindahl.  Instability and decay of the primary structure of DNA , 1993, Nature.

[94]  G. Wogan.  Aflatoxins as risk factors for hepatocellular carcinoma in humans. , 1992, Cancer research.

[95]  J. Simon,et al.  A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[96]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[97]  J. Wands,et al.  Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa , 1991, Nature.

[98]  R. Metcalf,et al.  Mutational hotspot in the p53 gene in human hepatocellular carcinomas. , 1991, Nature.

[99]  D. Ledbetter,et al.  Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. , 1989, Science.

[100]  E. Somers.  International Agency for Research on Cancer. , 1985, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[101]  Jeffrey H. Miller.  Carcinogens induce targeted mutations in Escherichia coli , 1982, Cell.

[102]  B. Ames,et al.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[103]  P. Armitage,et al.  The age distribution of cancer and a multi-stage theory of carcinogenesis , 1954, British Journal of Cancer.