Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling.

[1]  V. Hamburger,et al.  A series of normal stages in the development of the chick embryo. 1951. , 2012, Developmental dynamics : an official publication of the American Association of Anatomists.

[2]  K. Jalink,et al.  Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels. , 2007, Experimental cell research.

[3]  D. Kalderon,et al.  The Contributions of Protein Kinase A and Smoothened Phosphorylation to Hedgehog Signal Transduction in Drosophila melanogaster , 2006, Genetics.

[4]  C. Tickle,et al.  The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. , 2006, Genes & development.

[5]  K. Anderson,et al.  Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates , 2006, Development.

[6]  Aimin Liu,et al.  Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors , 2005, Development.

[7]  M. Scott,et al.  Communicating with Hedgehogs , 2005, Nature Reviews Molecular Cell Biology.

[8]  V. Centonze,et al.  Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities , 2005, Nature Genetics.

[9]  D. Ginty,et al.  Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins , 2005, Nature.

[10]  Liping Luo,et al.  Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I , 2004, Nature.

[11]  L. Lum,et al.  Extensive phosphorylation of Smoothened in Hedgehog pathway activation , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Cohen,et al.  The hedgehog signaling network , 2003, American journal of medical genetics. Part A.

[13]  Lee Niswander,et al.  Hedgehog signalling in the mouse requires intraflagellar transport proteins , 2003, Nature.

[14]  V. Centonze,et al.  PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. , 2003, Molecular cell.

[15]  M. Alessio,et al.  PBX1 nuclear export is regulated independently of PBX–MEINOX interaction by PKA phosphorylation of the PBC‐B domain , 2003, The EMBO journal.

[16]  Rolf Zeller,et al.  Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3 , 2002, Science.

[17]  Yina Li,et al.  Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity , 2002, Nature.

[18]  H. Yao,et al.  Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. , 2002, Developmental biology.

[19]  T. Pieler,et al.  Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling. , 2002, Differentiation; research in biological diversity.

[20]  P. T. Sharpe,et al.  Sonic hedgehog Regulates Epithelial Proliferation and Cell Survival in the Developing Tooth Germ , 2001, Journal of dental research.

[21]  P. Cohen,et al.  GSK3 takes centre stage more than 20 years after its discovery. , 2001, The Biochemical journal.

[22]  A. McMahon,et al.  The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. , 2001, Developmental biology.

[23]  J. I. Izpisúa Belmonte,et al.  Wnt signaling and PKA control Nodal expression and left-right determination in the chick embryo. , 2001, Development.

[24]  C. Tabin,et al.  Comparative biological responses to human Sonic, Indian, and Desert hedgehog , 2001, Mechanisms of Development.

[25]  N. Nakanishi,et al.  The role of an endogenous PKA inhibitor, PKIalpha, in organizing left-right axis formation. , 2001, Development.

[26]  Xin Zeng,et al.  A freely diffusible form of Sonic hedgehog mediates long-range signalling , 2001, Nature.

[27]  M. Cohn,et al.  Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. , 2000, Development.

[28]  Q. T. Wang,et al.  Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. , 2000, Development.

[29]  I. S. Kathiriya,et al.  Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway. , 2000, Development.

[30]  Philip A Beachy,et al.  Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb , 2000, Cell.

[31]  J. Rodríguez-León,et al.  The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb. , 1999, Development.

[32]  J. Jiang,et al.  Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus. , 1999, Genes & development.

[33]  Andrew P. McMahon,et al.  Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds , 1999, Nature.

[34]  D. Kalderon,et al.  Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. , 1999, Development.

[35]  Philip A Beachy,et al.  Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression , 1999, Cell.

[36]  E. Van Obberghen,et al.  Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase , 1999, Molecular and Cellular Biology.

[37]  M. Lyon,et al.  Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. , 1998, Development.

[38]  H. Ide,et al.  Shh, Bmp‐2 and Hoxd‐13 gene expression in chick limb bud cells in culture , 1998, Development, growth & differentiation.

[39]  R. Goodman,et al.  Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Clarke,et al.  Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. , 1997, Development.

[41]  C. Tickle,et al.  Fibroblast Growth Factor 4 Directs Gap Junction Expression in the Mesenchyme of the Vertebrate Limb Bud , 1997, The Journal of cell biology.

[42]  E. Van Obberghen,et al.  cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner , 1997, FEBS letters.

[43]  C. Tabin,et al.  Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. , 1996, Developmental biology.

[44]  S. Noji,et al.  Early chick limb cartilaginous elements possess polarizing activity and express hedgehog‐related morphogenetic factors , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[45]  M. Scott,et al.  Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. , 1996, Development.

[46]  R. Moon,et al.  Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. , 1996, Developmental biology.

[47]  Clifford J. Tabin,et al.  Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein , 1996, Science.

[48]  C. Tabin,et al.  Analysis of Hox gene expression in the chick limb bud. , 1996, Development.

[49]  M. Scott,et al.  Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. , 1996, Development.

[50]  M. Levine,et al.  Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. , 1996, Genes & development.

[51]  C. Chuong,et al.  cAMP, an activator of protein kinase A, suppresses the expression of sonic hedgehog. , 1996, Biochemical and biophysical research communications.

[52]  C. MacArthur,et al.  Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development , 1996, Cell.

[53]  Marc Tessier-Lavigne,et al.  Induction of midbrain dopaminergic neurons by Sonic hedgehog , 1995, Neuron.

[54]  M. Tessier-Lavigne,et al.  Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway , 1995, Cell.

[55]  G. Struhl,et al.  Protein kinase A and hedgehog signaling in drosophila limb development , 1995, Cell.

[56]  T. Jessell,et al.  Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord , 1994, Cell.

[57]  C. Tabin,et al.  Sonic hedgehog mediates the polarizing activity of the ZPA , 1993, Cell.

[58]  C. Tickle,et al.  FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro. , 1993, Development.

[59]  G. Martin,et al.  Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. , 1992, Development.

[60]  A Warner,et al.  The role of gap junctions in patterning of the chick limb bud. , 1990, Development.

[61]  G. McKnight,et al.  Regulation of transcription by cyclic AMP-dependent protein kinase. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[62]  B. Alberts,et al.  Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects , 1985, The Journal of cell biology.

[63]  L. Wolpert,et al.  Local application of retinoic acid to the limb bond mimics the action of the polarizing region , 1982, Nature.

[64]  R. Reiter,et al.  Stage- and position-related changes in chondrogenic response of chick embryonic wing mesenchyme to treatment with dibutyryl cyclic AMP. , 1981, Developmental biology.

[65]  C. Tickle.  The number of polarizing region cells required to specify additional digits in the developing chick wing , 1981, Nature.

[66]  J. Smith.  The time required for positional signalling in the chick wing bud. , 1980, Journal of embryology and experimental morphology.

[67]  D. Kalderon,et al.  Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction , 2005, Nature Cell Biology.

[68]  C. Tickle,et al.  Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. , 1994, Development.

[69]  D G Wilkinson,et al.  Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. , 1993, Methods in enzymology.