An alternative to time-varying elastance descriptions of the heart

Analytical models of the cardiovascular system typically use time-varying elastance descriptions of the heart chambers, e.g. the left ventricle. These elastance functions are derived from volume and pressure data. Consequently, although they are used to characterize the ventricle alone, their origin makes them characteristic of a particular ventricle and arterial load combination. This inability to separate source and load is eliminated by a new ventricle model based on a volume and time dependent isovolumic pressure function, derived from animal experiments.

[1]  A Noordergraaf,et al.  A perspective on myocardial contractility. , 1997, Technology and health care : official journal of the European Society for Engineering and Medicine.

[2]  H Suga,et al.  Time course of left ventricular pressure-volume relationship under various enddiastolic volume. , 1969, Japanese heart journal.

[3]  A. Shoukas,et al.  Load Independence of the Instantaneous Pressure‐Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio , 1973, Circulation research.

[4]  E. Yellin,et al.  Dynamic stiffness profiles in the left ventricle. , 1975, Journal of applied physiology.