Comparative morphology of Lacazia loboi (syn. Loboa loboi) in dolphins and humans.

Lacazia loboi (syn. Loboa loboi), the etiological agent of lobomycosis, was compared in human and dolphin tissue using light and electron microscopy, and computer-assisted morphometrics. The histological features of the lesions were similar; however, preliminary electron microscopy data indicates that cell wall destruction may vary in the two hosts. Calcofluor stained tissue sections of human and dolphin tissue were examined with UV light microscopy and the images digitized. Measurements of area, minimum and maximum diameters, and perimeter were made. Student's t-test (alpha = 0.01) revealed that L. loboi cells infecting dolphin tissue were significantly smaller than those infecting human tissue. This study represents the first comparative analysis of the morphology of the etiological agent of this disease in its two known natural hosts. The data indicate that the organism may not be identical in the two hosts.

[1]  M. Mcginnis,et al.  Lacazia loboi gen. nov., comb. nov., the Etiologic Agent of Lobomycosis , 2000, Journal of Clinical Microbiology.

[2]  D. Cowan,et al.  Isolation of fungal rDNA from bottlenose dolphin skin infected with Loboa loboi. , 1998, Medical mycology.

[3]  G. S. Paula,et al.  FIRST CASE OF LOBOMYCOSIS IN A BOTTLENOSE DOLPHIN FROM SOUTHERN BRAZIL , 1993 .

[4]  D. Cowan.  Lobo's Disease in a Bottlenose Dolphin (Tursiops truncates) from Matagorda Bay, Texas , 1993, Journal of wildlife diseases.

[5]  A. Sesso,et al.  The causative agent of Jorge Lobo's disease, the fungus P. loboi (= Loboa loboi) may be seen extracellularly tightly encircled by histiocytes. Observations at the transmission and scanning electron microscopes. , 1993, Revista do Instituto de Medicina Tropical de Sao Paulo.

[6]  A. Sesso,et al.  Interaction between macrophage and parasite cells in lobomycosis. The thickened cell wall of Paracoccidioides loboi exhibits apertures to the extracellular milieu. , 1988, Journal of submicroscopic cytology and pathology.

[7]  Bossart Gd.  Suspected acquired immunodeficiency in an Atlantic bottlenosed dolphin with chronic-active hepatitis and lobomycosis. , 1984 .

[8]  G. Bossart.  Suspected acquired immunodeficiency in an Atlantic bottlenosed dolphin with chronic-active hepatitis and lobomycosis. , 1984, Journal of the American Veterinary Medical Association.

[9]  M. M. Sampaio,et al.  The armadillo Euphractus sexcinctus as a suitable animal for experimental studies of Jorge Lobo's disease. , 1977, Revista do Instituto de Medicina Tropical de Sao Paulo.

[10]  H. McClure,et al.  Lobomycosis as a disease of the Atlantic bottle-nosed dolphin (Tursiops truncatus Montagu, 1821). , 1975, The American journal of tropical medicine and hygiene.

[11]  J. C. Woodard.  Electron microscopic study of lobomycosis (Loboa loboi). , 1972, Laboratory investigation; a journal of technical methods and pathology.

[12]  G. Migaki,et al.  Lobo's disease in an atlantic bottle-nosed dolphin. , 1971, Journal of the American Veterinary Medical Association.

[13]  M. M. Sampaio,et al.  Bizarre forms of the aetiologic agent in experimental Jorge Lôbo's disease in tortoises. , 1971, Revista do Instituto de Medicina Tropical de Sao Paulo.

[14]  M. M. Sampaio,et al.  Experimental infection of Jorge Lôbo's disease in the cheek-pouch of the golden hamster. , 1970, Revista do Instituto de Medicina Tropical de Sao Paulo.

[15]  N. Ishida,et al.  Specificity of binding of hexopyranosyl polysaccharides with fluorescent brightener. , 1967, Journal of biochemistry.

[16]  J. Wiersema,et al.  Lobo's disease in Surinam patients. , 1965, Tropical and geographical medicine.

[17]  J C WILT,et al.  Medical mycology. , 1952, Manitoba medical review.