Simvastatin suppresses experimental aortic aneurysm expansion.

[1]  J. Keaney,et al.  Cytokine-Stimulated GTP Cyclohydrolase I Expression in Endothelial Cells Requires Coordinated Activation of Nuclear Factor-&kgr;B and Stat1/Stat3 , 2005, Circulation research.

[2]  Robert W. Thompson,et al.  Treatment With Simvastatin Suppresses the Development of Experimental Abdominal Aortic Aneurysms in Normal and Hypercholesterolemic Mice , 2005, Annals of surgery.

[3]  Levon M Khachigian,et al.  Ets-1 Stimulates Platelet-Derived Growth Factor A-Chain Gene Transcription and Vascular Smooth Muscle Cell Growth via Cooperative Interactions With Sp1 , 2004, Circulation research.

[4]  D. Carey,et al.  Rapamycin suppresses experimental aortic aneurysm growth. , 2004, Journal of vascular surgery.

[5]  Neil J Stone,et al.  Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines , 2004, Circulation.

[6]  M. Aoki,et al.  Inhibition of Experimental Abdominal Aortic Aneurysm in the Rat by Use of Decoy Oligodeoxynucleotides Suppressing Activity of Nuclear Factor &kgr;B and ets Transcription Factors , 2003, Circulation.

[7]  A. Staubitz,et al.  Statins differ in their ability to block NF-kappaB activation in human blood monocytes. , 2003, International journal of clinical pharmacology and therapeutics.

[8]  Gorav Ailawadi,et al.  Current concepts in the pathogenesis of abdominal aortic aneurysm. , 2003, Journal of vascular surgery.

[9]  H. Schumacher,et al.  Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury. , 2003, Journal of vascular surgery.

[10]  Wan-Wan Lin,et al.  HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. , 2003, Journal of biomedical science.

[11]  G. Watanabe,et al.  Doxycycline Treatment in a Model of Early Abdominal Aortic Aneurysm , 2003, Surgery Today.

[12]  A. Newby,et al.  Statins Inhibit Secretion of Metalloproteinases-1, -2, -3, and -9 From Vascular Smooth Muscle Cells and Macrophages , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[13]  A. Curcio,et al.  Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Simvastatin Prevents Cardiac Hypertrophy Induced by Pressure Overload and Inhibits p21 ras Activation , 2002, Circulation.

[14]  J. Cristol,et al.  Simvastatin Prevents Angiotensin II–Induced Cardiac Alteration and Oxidative Stress , 2002, Hypertension.

[15]  M. Miyazaki,et al.  Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. , 2002, Journal of vascular surgery.

[16]  J. Paulauskis,et al.  Expression and regulation of the macrophage inflammatory protein-1 alpha gene by nicotine in rat alveolar macrophages. , 2002, European cytokine network.

[17]  N. Hagiwara,et al.  A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdominal aortic aneurysm wall. , 2002, Journal of vascular surgery.

[18]  V. Dixit,et al.  Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3* , 2002, The Journal of Biological Chemistry.

[19]  Robert W. Thompson,et al.  Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor. , 2002, Journal of vascular surgery.

[20]  David C. Han,et al.  Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease. , 2002, Journal of vascular surgery.

[21]  J D Humphrey,et al.  Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. , 2001, Journal of vascular surgery.

[22]  J. K. Lee,et al.  Experimental Abdominal Aortic Aneurysms in Mice Lacking Expression of Inducible Nitric Oxide Synthase , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[23]  A. Newby,et al.  Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. , 2001, Cardiovascular research.

[24]  D. Carey,et al.  Elastase is not sufficient to induce experimental abdominal aortic aneurysms. , 2001, Journal of vascular surgery.

[25]  David C. Han,et al.  Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion. , 2001, Journal of vascular surgery.

[26]  M. Isobe,et al.  Roles of P-Selectin in Inflammation, Neointimal Formation, and Vascular Remodeling in Balloon-Injured Rat Carotid Arteries , 2000, Circulation.

[27]  J. Bonventre,et al.  Gene 33/Mig-6, a Transcriptionally Inducible Adapter Protein That Binds GTP-Cdc42 and Activates SAPK/JNK* , 2000, The Journal of Biological Chemistry.

[28]  H. Birnboim,et al.  Expression of serum‐ and glucocorticoid‐regulated kinase (sgk) mRNA is up‐regulated by GM‐CSF and other proinflammatory mediators in human granulocytes , 2000, Journal of leukocyte biology.

[29]  T. Sasaki,et al.  Spatiotemporal changes of fibronectin, tenascin-C, fibulin-1, and fibulin-2 in the skin during the development of chronic contact dermatitis. , 1999, The Journal of investigative dermatology.

[30]  P. Baeuerle.  IκB–NF-κB Structures At the Interface of Inflammation Control , 1998, Cell.

[31]  M. Leinonen,et al.  Elevated circulating levels of inflammatory cytokines in patients with abdominal aortic aneurysm. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[32]  D. Harrison,et al.  Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. , 1996, The Journal of clinical investigation.

[33]  T. Vischer,et al.  Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein. , 1995, The Journal of rheumatology.

[34]  D. Loskutoff,et al.  Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. , 1995, The Journal of clinical investigation.

[35]  H. D. Zuchold,et al.  Evaluation of soluble CD14 and neopterin as serum parameters of the inflammatory activity of pulmonary sarcoidosis , 1992, The clinical investigator.

[36]  G. Chejfec,et al.  Correlation of inflammatory infiltrate with the enlargement of experimental aortic aneurysms. , 1992, Journal of vascular surgery.

[37]  J. Michel,et al.  Elastase-induced experimental aneurysms in rats. , 1990, Circulation.

[38]  James R Elmore,et al.  Nitric Oxide in Experimental Aneurysm Formation: Early Events and Consequences of Nitric Oxide Inhibition , 2002, Annals of vascular surgery.

[39]  D. Carey,et al.  The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms. , 1999, Journal of vascular surgery.

[40]  P. Baeuerle.  IkappaB-NF-kappaB structures: at the interface of inflammation control. , 1998, Cell.

[41]  S. Yoshiyuki,et al.  Sequence analysis of the putative regulatory region of rat α2-macroglobulin gene , 1987 .