Antihyperglycemic Activity of Banana (Musa nana Lour.) Peel and Its Active Ingredients in Alloxan-Induced Diabetic Mice

Previous studies have found that banana flowers, leaves, pseudostems, roots, infructescence stalks, and peels (M. paradisiacal (Linn.)) have antihyperglycemic effect. The banana peel (Musa nana Lour.) might have the antihyperglycemic activity, its antihyperglycemic activity and active ingredients remain to be elucidated. In this paper, fresh banana peel was sequential extraction using solvents with decreasing polarity. Then, the ethyl acetate and petroleum ether extracts (EBP and PBP) were chosen to evaluate the antihyperglycemic activity in alloxan-induced diabetic mice. And the antihyperglycemic activity guided fractionation of compounds. The EBP displayed potent antihyperglycemic activity. lupenone and -sitosterol were separated from EBP. Animal experiments results indicated that lupenone could effective reduce blood glucose of diabetic mice. The banana peel and its ingredient lupenone showed promising antihyperglycemic activity. The banana peel could be utilized as a natural source of antihyperglycemic food, health care or drug and lupenone has potential to develop as an antihyperglycemic drug.

[1]  F. Zameer,et al.  Investigation of antihyperglycaemic activity of banana (Musa sp. var. Nanjangud rasa bale) pseudostem in normal and diabetic rats. , 2015, Journal of the science of food and agriculture.

[2]  Yuanmin Wang,et al.  RP-HPLC Characterization of Lupenone and β-Sitosterol in Rhizoma Musae and Evaluation of the Anti-Diabetic Activity of Lupenone in Diabetic Sprague-Dawley Rats , 2014, Molecules.

[3]  S. Kandasamy,et al.  Antioxidant properties of isolated compounds from banana rhizome. , 2014, Journal of food science.

[4]  M. Aboul-Ela,et al.  Alloxan-induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of Rheum ribes L. in mouse model , 2014, Archives of pharmacal research.

[5]  J. Akhtar.  Antidiabetic potential of Musa paradisiaca in Streptozotocin- induced diabetic rats , 2014 .

[6]  Du Bing,et al.  Modulation of fasting blood glucose by raw banana powder in alloxan-induced diabetic rats , 2013 .

[7]  Barbara G Postal,et al.  Beneficial effects of banana leaves (Musa x paradisiaca) on glucose homeostasis: multiple sites of action , 2013 .

[8]  Eun-Kyung Ahn,et al.  Lupenone Isolated from Adenophora triphylla var. japonica Extract Inhibits Adipogenic Differentiation through the Downregulation of PPARγ in 3T3‐L1 Cells , 2013, Phytotherapy research : PTR.

[9]  E. Baydoun,et al.  Anti-hyperglycemic Effect of the Aqueous Extract of Banana Infructescence Stalks in Streptozotocin-induced Diabetic Rats , 2013, Plant Foods for Human Nutrition.

[10]  I. T. Babalola,et al.  Isolation of stigmast-5-en-3β-ol (β-sitosterol) from dichloromethane extract of Sterculia setigera Leaves (Sterculiaceae) , 2013 .

[11]  K. Shukla,et al.  Antidiabetic and antihyperlipidemic effects of the stem of Musa sapientum Linn. in streptozotocin-induced diabetic rats. , 2012, Journal of diabetes.

[12]  Jayasree Ganugapati,et al.  Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus , 2012, Bioinformation.

[13]  D. Pal,et al.  Isolation of β-sitosterol and evaluation of antidiabetic activity of Aristolochia indica in alloxan-induced diabetic mice with a reference to in-vitro antioxidant activity , 2012 .

[14]  P. Salimath,et al.  Beneficial effects of banana (Musa sp. var. elakki bale) flower and pseudostem on hyperglycemia and advanced glycation end-products (AGEs) in streptozotocin-induced diabetic rats , 2011, Journal of Physiology and Biochemistry.

[15]  Rajnish A. Gupta,et al.  Antidiabetic and antioxidant potential of β‐sitosterol in streptozotocin‐induced experimental hyperglycemia , 2011, Journal of diabetes.

[16]  D. Mohapatra,et al.  Banana and its by-product utilisation: an overview , 2010 .

[17]  M. Choudhary,et al.  Bioactive natural products from two Sudanese medicinal plants Diospyros mespiliformis and Croton zambesicus. , 2009 .

[18]  J. Ahn,et al.  Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta , 2009, Journal of enzyme inhibition and medicinal chemistry.

[19]  B. Anhwange,et al.  Chemical composition of Musa sapientum (banana) peels. , 2009 .

[20]  Michel Paquot,et al.  Dietary fibre components and pectin chemical features of peels during ripening in banana and plantain varieties. , 2008, Bioresource technology.

[21]  C. Alisi,et al.  Inhibition of dehydrogenase activity in pathogenic bacteria isolates by aqueous extracts of Musa paradisiaca (Var Sapientum) , 2008 .

[22]  P. Rai,et al.  Assessment of glycemic potential ofMusa paradisiaca stem juice , 2007, Indian Journal of Clinical Biochemistry.

[23]  F. Perazzo,et al.  Mutagenicity of the Musa paradisiaca (Musaceae) fruit peel extract in mouse peripheral blood cells in vivo. , 2008, Genetics and molecular research : GMR.

[24]  Huibin Zhang,et al.  A New isochroman-4-one Derivative from the Peel of Musa sapientum L. and Its Total Synthesis , 2007 .

[25]  Michel Paquot,et al.  Effects of the stage of maturation and varieties on the chemical composition of banana and plantain peels , 2007 .

[26]  R. Lin,et al.  [Studies on chemical constituents of Balanophora spicata]. , 2006, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[27]  F. Hashinaga,et al.  Antibacterial and Antioxidant Activities of Banana (Musa, AAA cv. Cavendish) Fruits Peel , 2005 .

[28]  L. Pari,et al.  Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats , 2000, Phytotherapy research : PTR.

[29]  J. Maheswari,et al.  Hypoglycaemic effect of Musa sapientum L. in alloxan-induced diabetic rats. , 1999, Journal of ethnopharmacology.

[30]  R. Román-Ramos,et al.  Study of the anti-hyperglycemic effect of plants used as antidiabetics. , 1998, Journal of ethnopharmacology.

[31]  T. Akihisa,et al.  Cycloartane triterpenes from the fruit peel of Musa sapientum , 1998 .