Facile synthesis of phosphonamidate‐ and phosphonate‐linked phosphonopeptides

A direct method for the preparation of phosphonamidate‐ and phosphonate‐linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one‐pot reactions of benzyl carbamate, aldehydes, and methyl dichlorophosphite, followed by aminolysis with amino acid esters or alcoholysis with hydroxy esters. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.

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