Analysis of K‐ras mutations and expression of cyclooxygenase‐2 and gastrin protein in laterally spreading tumors

Background and Aim: Recent advances in colonoscopic techniques have led to the increased detection of, and interest in, superficial type colorectal tumors, and a new category, the ‘laterally spreading tumor (LST)’, has been proposed. However, the characteristics of the genetic alterations in these LSTs have not yet been fully determined. We therefore classified LSTs as LST‐granular (LST‐G) or LST‐non‐granular (LST‐NG), according to their macroscopic appearance, and examined the genetic alterations in these two tumor groups compared with those in protruded type tumors.

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