Analysis of K‐ras mutations and expression of cyclooxygenase‐2 and gastrin protein in laterally spreading tumors

Background and Aim: Recent advances in colonoscopic techniques have led to the increased detection of, and interest in, superficial type colorectal tumors, and a new category, the ‘laterally spreading tumor (LST)’, has been proposed. However, the characteristics of the genetic alterations in these LSTs have not yet been fully determined. We therefore classified LSTs as LST‐granular (LST‐G) or LST‐non‐granular (LST‐NG), according to their macroscopic appearance, and examined the genetic alterations in these two tumor groups compared with those in protruded type tumors.

[1]  J. Gutkind,et al.  Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways , 2002, The Journal of Biological Chemistry.

[2]  C. Paraskeva,et al.  Human colorectal adenomas demonstrate a size‐dependent increase in epithelial cyclooxygenase‐2 expression , 2002, The Journal of pathology.

[3]  P. Guillou,et al.  Interstitial cell cyclooxygenase‐2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas , 2002, Journal of Pathology.

[4]  이석호,et al.  Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study , 2001, British Journal of Cancer.

[5]  T. Ogihara,et al.  Laterally spreading tumor: Clinicopathological study in comparison with the depressed type of colorectal tumor , 2001, Journal of gastroenterology and hepatology.

[6]  H. Sheng,et al.  K-Ras-mediated increase in cyclooxygenase 2 mRNA stability involves activation of the protein kinase B1. , 2001, Cancer research.

[7]  E. Gerner,et al.  Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. , 2000, Cancer research.

[8]  T. Fujimori,et al.  Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas. , 2000, Journal of gastroenterology and hepatology.

[9]  T. Fujimori,et al.  Analysis of K‐ras codon 12 mutations and p53 overexpression in colorectal nodule‐aggregating tumors , 2000, Journal of gastroenterology and hepatology.

[10]  M. Bissonnette,et al.  Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. , 2000, Cancer research.

[11]  T. Wang,et al.  Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. , 2000, Gastroenterology.

[12]  J. Westwick,et al.  Oncogenic ras induces gastrin gene expression in colon cancer. , 1998, Gastroenterology.

[13]  J. Chiang,et al.  K-ras codon 12 mutation determines the polypoid growth of colorectral cancer. , 1998, Cancer research.

[14]  A. Norman,et al.  Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. , 1998, Journal of the National Cancer Institute.

[15]  H. J. Kim,et al.  Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. , 1997, Gastroenterology.

[16]  R. DuBois,et al.  Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[17]  H. Höfler,et al.  EXPRESSION OF bcl‐2 AND p53 IN DE NOVO AND EX‐ADENOMA COLON CARCINOMA: A COMPARATIVE IMMUNOHISTOCHEMICAL STUDY , 1996, The Journal of pathology.

[18]  T. Wood,et al.  Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. , 1996, Cancer research.

[19]  G. Ciccotosto,et al.  Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. , 1995, Gastroenterology.

[20]  M. Kondo,et al.  Expression of cyclooxygenase-1 and -2 in human colorectal cancer. , 1995, Cancer research.

[21]  S Jothy,et al.  Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. , 1995, Cancer research.

[22]  T. Muto,et al.  Polypoid growth and K‐ras codon 12 mutation in coiorectal cancer , 1995, Cancer.

[23]  R. Coffey,et al.  Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. , 1994, Gastroenterology.

[24]  S. Maeda,et al.  Comparative clinicopathological and immunohistochemical study of ras and p53 in flat and polypoid type colorectal tumours. , 1994, Gut.

[25]  S. Maeda,et al.  Non‐involvement of ras mutations in flat colorectal adenomas and carcinomas , 1994, International journal of cancer.

[26]  S. Kudo,et al.  Endoscopic Mucosal Resection of Flat and Depressed Types of Early Colorectal Cancer , 1993, Endoscopy.

[27]  R. Koski,et al.  Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. , 1993, Cancer research.

[28]  J. Rehfeld,et al.  Expression but incomplete maturation of progastrin in colorectal carcinomas. , 1993, Gastroenterology.

[29]  K. Seibert,et al.  Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[30]  B. Varnum,et al.  TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. , 1991, The Journal of biological chemistry.

[31]  J. Guillem,et al.  Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer. , 1989, Oncogene.

[32]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[33]  B. Crawford,et al.  Small nonpolypoid carcinomas of the large intestine , 1983, Cancer.

[34]  K. Imai,et al.  Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors) , 2003, Journal of Gastroenterology.

[35]  G. Qvigstad,et al.  The CCK-2 receptor is located on the ECL cell, but not on the parietal cell. , 2001, Scandinavian journal of gastroenterology.

[36]  F. Sundler,et al.  Trophic effects of continuous infusion of [Leu15]-gastrin-17 in the rat. , 1990, Gastroenterology.