论文信息 - Mutations in the NOG gene are not a common cause of nonsyndromic premature ovarian failure

Mutations in the NOG gene are not a common cause of nonsyndromic premature ovarian failure

Premature ovarian failure (POF) is clinically defined as at least 6 months of amenorrhoea and elevated plasmatic levels of FSH in women below the age of 40 years. It affects about 1% of women under 40. 1 POF has been described to be associated with autoimmune diseases, pelvic surgery, chemotherapy, radiotherapy, infectious agents and environmental factors. In some cases, genetic causes have been identified. They include X chromosomal alterations (i.e. Turner Syndrome) and mutations in autosomal and X-linked genes. 1

R. Veitia | M. Fellous | P. Laissue | S. Christin‐Maitre | P. Bouchard

[1] T. Ogata,et al. Premature ovarian failure in a female with proximal symphalangism and Noggin mutation. , 2004, Fertility and sterility.

[2] F. Otsuka,et al. The bone morphogenetic protein system in mammalian reproduction. , 2004, Endocrine reviews.

[3] Markus Affolter,et al. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin , 2002, Nature.

[4] B. Campbell,et al. Effect of bone morphogenetic protein 2 (BMP2) on oestradiol and inhibin A production by sheep granulosa cells, and localization of BMP receptors in the ovary by immunohistochemistry. , 2002, Reproduction.

[5] N. Ueno,et al. A functional bone morphogenetic protein system in the ovary. , 1999, Proceedings of the National Academy of Sciences of the United States of America.