Optimization of photodynamic therapy with a novel self‐adhesive 5‐aminolaevulinic acid patch: results of two randomized controlled phase III studies

Background  Photodynamic therapy (PDT) is increasingly used for treatment of actinic keratoses (AKs) but is a cumbersome procedure. A thin self‐adhesive patch (PD P 506 A) containing 5‐aminolaevulinic acid (5‐ALA) was developed to facilitate PDT.

[1]  A. Hauschild,et al.  Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self‐adhesive 5‐aminolaevulinic acid patch , 2009, Experimental dermatology.

[2]  A. Moor,et al.  Fluorescence characteristics and pharmacokinetic properties of a novel self-adhesive 5-ALA patch for photodynamic therapy of actinic keratoses , 2008, Archives of Dermatological Research.

[3]  H. Kerl,et al.  Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclassification , 2007, The British journal of dermatology.

[4]  A. Oseroff,et al.  Aminolevulinic acid photodynamic therapy for skin cancers. , 2007, Dermatologic clinics.

[5]  E. Tschen,et al.  Photodynamic therapy using aminolaevulinic acid for patients with nonhyperkeratotic actinic keratoses of the face and scalp: phase IV multicentre clinical trial with 12‐month follow up , 2006, The British journal of dermatology.

[6]  Cynthia C. Morton,et al.  Intraindividual, right–left comparison of topical methyl aminolaevulinate‐photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study , 2006, The British journal of dermatology.

[7]  H. Kerl,et al.  Guidelines for the management of actinic keratoses. , 2006, European journal of dermatology : EJD.

[8]  T. Ehrig,et al.  Actinic Keratoses and the Incidence of Occult Squamous Cell Carcinoma: A Clinical–Histopathologic Correlation , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[9]  G. Hruza.  Aminolevulinic Acid Photodynamic Therapy for Acne , 2004 .

[10]  A. Halpern,et al.  Awareness of, knowledge of and attitudes to nonmelanoma skin cancer (NMSC) and actinic keratosis (AK) among physicians , 2004, International journal of dermatology.

[11]  D. Murrell,et al.  A prospective study of the use of cryosurgery for the treatment of actinic keratoses , 2004, International journal of dermatology.

[12]  D. Murrell,et al.  A comparison of photodynamic therapy using topical methyl aminolevulinate (Metvix®) with single cycle cryotherapy in patients with actinic keratosis: a prospective, randomized study , 2003, The Journal of dermatological treatment.

[13]  R. M. Szeimiesa,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002 .

[14]  D. Salomon,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002, Journal of the American Academy of Dermatology.

[15]  E. Jeffes,et al.  Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light. , 2001, Journal of the American Academy of Dermatology.

[16]  B. Jarvis,et al.  Topical Aminolevulinic Acid HCl Photodynamic Therapy , 2000, American journal of clinical dermatology.

[17]  C. Cockerell,et al.  Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis"). , 2000, Journal of the American Academy of Dermatology.

[18]  C. Cockerell,et al.  Actinic Keratoses , 1997 .

[19]  H. Hönigsmann,et al.  Photodynamic therapy of epithelial skin tumours using delta‐aminolaevulinic acid and desferrioxamine , 1995, The British journal of dermatology.

[20]  近藤 哲,et al.  示-175 消化器癌手術例に対する蛋白分解酵素阻害剤ウリナスタチン投与のprospective randomized study(第2報)(示-その他-4(ショック,エンドトキシン)) , 1994 .

[21]  T. Dougherty.  Photodynamic therapy. , 1993, Photochemistry and photobiology.

[22]  S. A. Zacarian.  Cryosurgery in dermatology. , 1967, International surgery.