O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

[1]  D. Vocadlo,et al.  Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody , 2011, Amino Acids.

[2]  A. Ibrahim,et al.  O-Glcnacylation of TAB1 modulates TAK1-mediated cytokine release , 2010 .

[3]  M. Wolfert,et al.  Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. , 2010, Nature chemical biology.

[4]  G. Hart,et al.  The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways , 2010, Journal of Cell Science.

[5]  J. Hanover,et al.  O-GlcNAc cycling: implications for neurodegenerative disorders. , 2009, The international journal of biochemistry & cell biology.

[6]  N. Tanaka,et al.  Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification , 2009, Proceedings of the National Academy of Sciences.

[7]  J. Ninomiya-Tsuji,et al.  TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling* , 2008, Journal of Biological Chemistry.

[8]  E. Kang,et al.  NFκB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions , 2008, Proceedings of the National Academy of Sciences.

[9]  A. W. Schüttelkopf,et al.  Structural insights into mechanism and specificity of O-GlcNAc transferase , 2008, The EMBO journal.

[10]  D. Guerini,et al.  The O‐linked N‐acetylglucosamine modification in cellular signalling and the immune system , 2008, EMBO reports.

[11]  G. Hart,et al.  Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. , 2008, American journal of physiology. Endocrinology and metabolism.

[12]  M. Dorf,et al.  Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling. , 2008, Cellular signalling.

[13]  S. Ghosh,et al.  Shared Principles in NF-κB Signaling , 2008, Cell.

[14]  P. Cohen,et al.  Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. , 2008, The Biochemical journal.

[15]  P. Lucas,et al.  A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation , 2008 .

[16]  Zhijian J. Chen,et al.  Ubiquitin-mediated activation of TAK1 and IKK , 2007, Oncogene.

[17]  Gerald W. Hart,et al.  Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins , 2007, Nature.

[18]  D. V. van Aalten,et al.  GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels. , 2006, Journal of the American Chemical Society.

[19]  P. Cohen,et al.  TAK1-binding protein 1 is a pseudophosphatase. , 2006, The Biochemical journal.

[20]  S. Akira,et al.  Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation , 2006, Journal of Biological Chemistry.

[21]  D. V. van Aalten,et al.  Structural insights into the mechanism and inhibition of eukaryotic O‐GlcNAc hydrolysis , 2006, The EMBO journal.

[22]  J. Hanover,et al.  The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code" , 2005, Science's STKE.

[23]  Ki-Young Lee,et al.  TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. , 2005, Genes & development.

[24]  S. Akira,et al.  Essential function for the kinase TAK1 in innate and adaptive immune responses , 2005, Nature Immunology.

[25]  G. Hart,et al.  Perturbations in O-linked β-N-Acetylglucosamine Protein Modification Cause Severe Defects in Mitotic Progression and Cytokinesis* , 2005, Journal of Biological Chemistry.

[26]  H. Sakurai,et al.  Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-β-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2* , 2005, Journal of Biological Chemistry.

[27]  Zhijian J. Chen,et al.  TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  G. Hart,et al.  Dynamic O-GlcNAc Modification of Nucleocytoplasmic Proteins in Response to Stress , 2004, Journal of Biological Chemistry.

[29]  P. Cohen,et al.  TAB3, a new binding partner of the protein kinase TAK1. , 2004, The Biochemical journal.

[30]  Linda C Hsieh-Wilson,et al.  A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications. , 2003, Journal of the American Chemical Society.

[31]  R. Gaynor,et al.  Role of the TAB2‐related protein TAB3 in IL‐1 and TNF signaling , 2003, The EMBO journal.

[32]  M. Fukuda,et al.  Diabetes and the Accompanying Hyperglycemia Impairs Cardiomyocyte Calcium Cycling through Increased Nuclear O-GlcNAcylation* , 2003, Journal of Biological Chemistry.

[33]  P. Cohen,et al.  Feedback control of the protein kinase TAK1 by SAPK2a/p38α , 2003, The EMBO journal.

[34]  J. Ninomiya-Tsuji,et al.  Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis , 2002, Mechanisms of Development.

[35]  G. Hart,et al.  The Emerging Significance of O-GlcNAc in Cellular Regulation , 2002 .

[36]  G. Hart,et al.  Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens. , 2002, The Journal of biological chemistry.

[37]  G. Hart,et al.  Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Karin,et al.  Missing Pieces in the NF-κB Puzzle , 2002, Cell.

[39]  G. Hart,et al.  The emerging significance of O-GlcNAc in cellular regulation. , 2002, Chemical reviews.

[40]  G. Hart,et al.  Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins , 2002, The Journal of Biological Chemistry.

[41]  Zhijian J. Chen,et al.  TAK1 is a ubiquitin-dependent kinase of MKK and IKK , 2001, Nature.

[42]  J. Ninomiya-Tsuji,et al.  An Evolutionarily Conserved Motif in the TAB1 C-terminal Region Is Necessary for Interaction with and Activation of TAK1 MAPKKK* , 2001, The Journal of Biological Chemistry.

[43]  G. Hart,et al.  Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins , 2001, The Journal of Biological Chemistry.

[44]  G. Hart,et al.  O-Glycosylation of Nuclear and Cytosolic Proteins , 2000, The Journal of Biological Chemistry.

[45]  J. Mizukami,et al.  Phosphorylation‐dependent activation of TAK1 mitogen‐activated protein kinase kinase kinase by TAB1 , 2000, FEBS letters.

[46]  G. Hart,et al.  The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[47]  J. Hanover,et al.  Functional Expression of O-linked GlcNAc Transferase , 2000, The Journal of Biological Chemistry.

[48]  G. Hart,et al.  O-GlcNAc and the control of gene expression. , 1999, Biochimica et biophysica acta.

[49]  G. Hart,et al.  Regulation of a Cytosolic and Nuclear O-GlcNAc Transferase , 1999, The Journal of Biological Chemistry.

[50]  Jill K Thompson,et al.  Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation* , 1999, The Journal of Biological Chemistry.

[51]  J. Ninomiya-Tsuji,et al.  The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway , 1999, Nature.

[52]  J. Hanover,et al.  Elevated O-LinkedN-Acetylglucosamine Metabolism in Pancreatic β-Cells , 1999 .

[53]  G. Hart,et al.  Dynamic Glycosylation of Nuclear and Cytosolic Proteins , 1997, The Journal of Biological Chemistry.

[54]  R. Kind,et al.  The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase , 1996, Science.

[55]  B K Hayes,et al.  O-GlcNAcylation of key nuclear and cytoskeletal proteins: reciprocity with O-phosphorylation and putative roles in protein multimerization. , 1996, Glycobiology.

[56]  K. Irie,et al.  TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction , 1996, Science.

[57]  M. Karin,et al.  Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation , 1996, Molecular and cellular biology.

[58]  K. Irie,et al.  Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.

[59]  B. Schmitz,et al.  O-linked N-acetylglucosamine is upregulated in Alzheimer brains. , 1995, Biochemical and biophysical research communications.

[60]  P. Lucas,et al.  A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. , 2008, The EMBO journal.

[61]  G. Hart,et al.  Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins. , 2007, Nature.

[62]  Inder M Verma,et al.  NF-kappaB regulation in the immune system. , 2002, Nature reviews. Immunology.

[63]  P. Nielsen,et al.  A conformationally locked tricyclic nucleoside. Synthesis, crystal structure and incorporation into oligonucleotides , 2001 .

[64]  M. Karin,et al.  Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. , 2000, Annual review of immunology.

[65]  R. Hay,et al.  Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation. , 1999, The Journal of biological chemistry.

[66]  U. Saha,et al.  Efficient synthesis ofO-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-serine and -threonine building blocks for glycopeptideformation , 1997 .

[67]  K. Irie,et al.  TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. , 1996, Science.