Effects of the Oxygen depletion in FLASH irradiation investigated through Geant4-DNA toolkit

[1]  S. Incerti,et al.  Modeling of scavenging systems in water radiolysis with Geant4-DNA. , 2023, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[2]  C. King,et al.  Modulating Nucleus Oxygen Concentration by Altering Intramembrane Cholesterol Levels: Creating Hypoxic Nucleus in Oxic Conditions , 2022, International journal of molecular sciences.

[3]  S. Incerti,et al.  Status and Extension of the Geant4-DNA Dielectric Models for Application to Electron Transport , 2022, Frontiers in Physics.

[4]  S. Incerti,et al.  Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level , 2021, Cancers.

[5]  S. Incerti,et al.  Geant4-DNA simulation of the pre-chemical stage of water radiolysis and its impact on initial radiochemical yields. , 2021, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[6]  P. J. Hoopes,et al.  Quantification of oxygen depletion during FLASH irradiation in vitro and in vivo. , 2021, International journal of radiation oncology, biology, physics.

[7]  M. Durante,et al.  May oxygen depletion explain the FLASH effect? A chemical track structure analysis. , 2021, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[8]  X. Jia,et al.  Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy , 2020, Physics in medicine and biology.

[9]  S. Incerti,et al.  Independent Reaction Times method in Geant4-DNA: implementation and performance. , 2020, Medical physics.

[10]  J. Parsons,et al.  FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy , 2020, International journal of molecular sciences.

[11]  M. Mendonca,et al.  Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review , 2020, Physics in medicine and biology.

[12]  K. Butterworth,et al.  A quantitative analysis of the role of oxygen tension in FLASH radiotherapy. , 2020, International journal of radiation oncology, biology, physics.

[13]  E. Hammond,et al.  Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold? , 2020, Frontiers in Oncology.

[14]  M. Durante,et al.  Impact of Target Oxygenation on the Chemical Track Evolution of Ion and Electron Radiation , 2020, International journal of molecular sciences.

[15]  E. Azzam,et al.  The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy. , 2019, Radiation research.

[16]  J. Bourhis,et al.  Treatment of a first patient with FLASH-radiotherapy. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[17]  M. Brand,et al.  Feasibility of proton FLASH effect tested by zebrafish embryo irradiation. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[18]  B. Faddegon,et al.  Evaluation of the influence of physical and chemical parameters on water radiolysis simulations under MeV electron irradiation using Geant4-DNA , 2019, Journal of Applied Physics.

[19]  T. Waldron,et al.  An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[20]  D. Brenner,et al.  Biological effects in normal cells exposed to FLASH dose rate protons. , 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[21]  D Sakata,et al.  Geant4‐DNA example applications for track structure simulations in liquid water: A report from the Geant4‐DNA Project , 2018, Medical physics.

[22]  J. Bourhis,et al.  The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients , 2018, Clinical Cancer Research.

[23]  J Schuemann,et al.  Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio , 2018, Physics in medicine and biology.

[24]  Marco Durante,et al.  TRAX-CHEM: A pre-chemical and chemical stage extension of the particle track structure code TRAX in water targets , 2018 .

[25]  Marco Durante,et al.  Faster and safer? FLASH ultra-high dose rate in radiotherapy. , 2017, The British journal of radiology.

[26]  L. Devroye,et al.  Considerations for the independent reaction times and step-by-step methods for radiation chemistry simulations , 2017 .

[27]  S. Incerti,et al.  Simulation of early DNA damage after the irradiation of a fibroblast cell nucleus using Geant4-DNA , 2017, Scientific Reports.

[28]  Susanna Guatelli,et al.  Microdosimetry of electrons in liquid water using the low-energy models of Geant4 , 2017 .

[29]  Claude Bailat,et al.  Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s. , 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[30]  M. Beuve,et al.  Simulation of ion-induced water radiolysis in different conditions of oxygenation , 2015 .

[31]  M. Partridge,et al.  A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio , 2015, Biomedical physics & engineering express.

[32]  L Maigne,et al.  Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit. , 2015, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[33]  M. Durante,et al.  Kill-painting of hypoxic tumours in charged particle therapy , 2015, Scientific Reports.

[34]  M. A. Cortés-Giraldo,et al.  Recent developments in GEANT4 , 2015 .

[35]  M. Beuve,et al.  Biological systems: from water radiolysis to carbon ion radiotherapy , 2015 .

[36]  S. Incerti,et al.  Technical Note: Improvements in geant4 energy-loss model and the effect on low-energy electron transport in liquid water. , 2015, Medical physics.

[37]  Philippe Hupé,et al.  Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice , 2014, Science Translational Medicine.

[38]  C Villagrasa,et al.  Comparison of GEANT4 very low energy cross section models with experimental data in water. , 2010, Medical physics.

[39]  P. Moretto,et al.  The Geant4-DNA Project , 2009, Int. J. Model. Simul. Sci. Comput..

[40]  Marie Davídková,et al.  Impact of oxygen concentration on yields of DNA damages caused by ionizing radiation , 2008 .

[41]  Noam Agmon,et al.  Theory and simulation of diffusion-controlled Michaelis-Menten kinetics for a static enzyme in solution. , 2008, The journal of physical chemistry. B.

[42]  S. Incerti,et al.  Geant4 developments and applications , 2006, IEEE Transactions on Nuclear Science.

[43]  Simon M. Pimblott,et al.  Stochastic Simulation of the Electron Radiolysis of Water and Aqueous Solutions , 1997 .

[44]  John A. Murphy,et al.  Reactions of oxyl radicals with DNA. , 1995, Free radical biology & medicine.

[45]  L. H. Gray,et al.  The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. , 1953, The British journal of radiology.

[46]  Petteri Nieminen,et al.  Modeling Radiation Chemistry in the Geant4 Toolkit , 2011 .

[47]  Michaël Beuve,et al.  O2 and glutathione effects on water radiolysis: a simulation study , 2011 .

[48]  Hooshang Nikjoo,et al.  Monte Carlo simulation of water radiolysis for low-energy charged particles. , 2006, Journal of radiation research.

[49]  A. Dell'Acqua,et al.  Geant4 - A simulation toolkit , 2003 .

[50]  Michael J. Pilling,et al.  Stochastic modeling of fast kinetics in a radiation track , 1990 .