2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

[1]  X. Fradera,et al.  Dioxo-triazines as a novel series of cathepsin K inhibitors. , 2010, Bioorganic & medicinal chemistry letters.

[2]  X. Fradera,et al.  Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. , 2010, Bioorganic & medicinal chemistry letters.

[3]  D. Brömme,et al.  Cathepsin K inhibitors for osteoporosis and potential off-target effects , 2009, Expert opinion on investigational drugs.

[4]  Soraya S. Porres,et al.  5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[5]  S. Bevan,et al.  Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-cyanopyrimidines. Part 2. , 2008, Bioorganic & medicinal chemistry letters.

[6]  S. Bevan,et al.  Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. , 2008, Journal of medicinal chemistry.

[7]  Ikuo Sugiyama,et al.  Effect of cathepsin K inhibitors on bone resorption. , 2008, Journal of medicinal chemistry.

[8]  T. Kanazawa,et al.  4-Amino-2-cyanopyrimidines: novel scaffold for nonpeptidic cathepsin S inhibitors. , 2008, Bioorganic & Medicinal Chemistry Letters.

[9]  T. Kanazawa,et al.  Discovery of selective and nonpeptidic cathepsin S inhibitors. , 2008, Bioorganic & medicinal chemistry letters.

[10]  C. Betschart,et al.  New chemotypes for cathepsin K inhibitors. , 2008, Bioorganic & medicinal chemistry letters.

[11]  A. Ray,et al.  Cysteine cathepsin S as an immunomodulatory target: present and future trends , 2008, Expert opinion on therapeutic targets.

[12]  O. Ohmori,et al.  Novel scaffold for cathepsin K inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[13]  M. Percival,et al.  The identification of potent, selective, and bioavailable cathepsin S inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[14]  S. Bevan,et al.  Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain , 2007, Proceedings of the National Academy of Sciences.

[15]  E. Altmann,et al.  2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. , 2007, Journal of medicinal chemistry.

[16]  J. Falgueyret,et al.  Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. , 2005, Journal of medicinal chemistry.

[17]  Z. Rankovic,et al.  Cathepsin K inhibitors, 2000 – 2004 , 2005 .

[18]  E. Altmann,et al.  Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K. , 2004, Journal of medicinal chemistry.

[19]  Vincent Leroy,et al.  Cathepsin S inhibitors , 2004 .

[20]  D. Cutler,et al.  The potential role of lysosomes in tissue distribution of weak bases , 1988, Biopharmaceutics & drug disposition.