Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.
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S. Green | Rebecca P A Ellston | B. Barlaam | S. Degorce | M. Maudet | R. Morgentin | P. Plé | S. Cosulich | Urs J Hancox | M. Fitzek | Lara Ward | C. Lambert-van der Brempt | J. Lohmann | Nicolas Warin